Lack of effect of 1 year intake of a high-dose vitamin and mineral supplement on cognitive function of elderly women

To determine if long-term, high-vitamin supplementation could reverse cognitive malfunction in old people. We performed a longitudinal study relating the 12-month outcome to baseline values. Twenty non-vitamin-deficient elderly females with a Folstein mini mental state examination score indicating c...

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Bibliographic Details
Published in:	Gerontology (Basel) Vol. 45; no. 4; p. 195
Main Authors:	Baker, H, De Angelis, B, Baker, E R, Frank, O, Jaslowdagger, S P
Format:	Journal Article
Language:	English
Published:	Switzerland 01-07-1999
Subjects:	Aged Aged, 80 and over Aging Cognition Disorders - drug therapy Female Follow-Up Studies Humans Mental Status Schedule Minerals - administration & dosage Minerals - blood Treatment Failure Vitamins - administration & dosage Vitamins - blood
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Summary:	To determine if long-term, high-vitamin supplementation could reverse cognitive malfunction in old people. We performed a longitudinal study relating the 12-month outcome to baseline values. Twenty non-vitamin-deficient elderly females with a Folstein mini mental state examination score indicating cognitive malfunctions were recruited to ascertain if feeding a high-dose vitamin-mineral supplement for 1 year could, by mass vitamin action, reverse some existing cognitive malfunctions. Ten females were fed a high-dose vitamin-mineral supplement pill with each of three daily meals for 1 year; the other 10 did not receive this supplementation. Twelve blood vitamin analyses and a Folstein mini mental state examination were performed for each of the 20 subjects before and after 1 year; each subject served as its own control. No improvement in cognitive malfunction was noted despite elevation of blood vitamins. Feeding of a high-dose vitamin and mineral supplement for 1 year did not improve cognitive malfunction in non-vitamin-deficient elderly in this study.
ISSN:	0304-324X
DOI:	10.1159/000022086