Search Results - "Jaskoll, Tina"

Human cytomegalovirus and mucoepidermoid carcinoma of salivary glands: Cell-specific localization of active viral and oncogenic signaling proteins is confirmatory of a causal relationship by Melnick, Michael, Sedghizadeh, Parish P., Allen, Carl M., Jaskoll, Tina

“…Human cytomegalovirus (hCMV) infection is common. Although still controversial, there is growing evidence that active hCMV infection is associated with a…”
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FGF10/FGFR2b signaling plays essential roles during in vivo embryonic submandibular salivary gland morphogenesis by Jaskoll, Tina, Abichaker, George, Witcher, Daniel, Sala, Frederic G, Bellusci, Saverio, Hajihosseini, Mohammad K, Melnick, Michael

“…Analyses of Fgf10 and Fgfr2b mutant mice, as well as human studies, suggest that FGF10/FGFR2b signaling may play an essential, nonredundant role during…”
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Cytomegalovirus-induced embryopathology: mouse submandibular salivary gland epithelial-mesenchymal ontogeny as a model by Melnick, Michael, Mocarski, Edward S, Abichaker, George, Huang, Jing, Jaskoll, Tina

“…Human studies suggest, and mouse models clearly demonstrate, that cytomegalovirus (CMV) is dysmorphic to early organ and tissue development. CMV has a…”
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Cytomegalovirus inhibition of embryonic mouse tooth development: A model of the human amelogenesis imperfecta phenocopy by Jaskoll, Tina, Abichaker, George, Jangaard, Nolan, Bringas, Pablo, Melnick, Michael

“…Abstract Objective Cytomegalovirus (CMV) is one of the most common causes of major birth defects in humans. Of the approximately 8400 children born each year…”
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Embryonic salivary gland dysmorphogenesis in Twisted gastrulation deficient mice by Melnick, Michael, Petryk, Anna, Abichaker, George, Witcher, Dan, Person, Anthony D., Jaskoll, Tina

“…Mouse Twisted gastrulation gene ( Twsg1) expression is found throughout embryonic development, including substantial levels in the first branchial arch that…”
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Mouse submandibular gland morphogenesis: a paradigm for embryonic signal processing by Melnick, M, Jaskoll, T

“…Signal processing is the sine qua non of embryogenesis. At its core, any single signal transduction pathway may be understood as classic Information Theory,…”
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CMV-induced embryonic mouse organ of corti dysplasia: Network architecture of dysfunctional lateral inhibition by Melnick, Michael, Jaskoll, Tina

“…Background Congenital cytomegalovirus infection is the major nongenetic cause of sensorineural hearing loss at birth and beyond. Among other pathologies, there…”
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An in vitro mouse model of congenital cytomegalovirus-induced pathogenesis of the inner ear cochlea by Melnick, Michael, Jaskoll, Tina

“…Congenital human cytomegalovirus (CMV) infection is the leading nongenetic etiology of sensorineural hearing loss (SNHL) at birth and prelingual SNHL not…”
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An alternatively spliced Muc10 glycoprotein ligand for putative l-selectin binding during mouse embryonic submandibular gland morphogenesis by Melnick, Michael, Chen, Haiming, Zhou, Yan-Min, Jaskoll, Tina

“…Late-gestation (embryonic day 18; E18) mouse submandibular glands (SMG) comprise a network of large and small ducts that terminate in lumen-containing,…”
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Interleukin-6 signaling and embryonic mouse submandibular salivary gland morphogenesis by Melnick, M, Chen, H, Zhou, Y M, Jaskoll, T

“…Interleukin-6 (IL-6) is a multifunctional cytokine that mediates cell growth, differentiation, and survival. It was the objective of the present study to…”
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CMV-induced pathology: pathway and gene–gene interaction analysis by Melnick, Michael, Deluca, Krysta A., Jaskoll, Tina

“…Mucoepidermoid carcinoma (MEC) is the most prevalent malignant tumor in major and minor salivary glands (SGs). We have recently identified human…”
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Human cytomegalovirus and mucoepidermoid carcinoma of salivary glands: cell‐specific localization of active viral and oncogenic signaling proteins by Melnick, Michael, Sedghizadeh, Parish P, Allen, Carl M, Jaskoll, Tina

“…Abstract only Human cytomegalovirus (hCMV) infection is common. Given that hCMV is frequently resident in salivary gland (SG) ductal epithelium, we…”
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Cytomegalovirus-induced salivary gland pathology: AREG, FGF8, TNF-α, and IL-6 signal dysregulation and neoplasia by Melnick, Michael, Deluca, Krysta A., Sedghizadeh, Parish P., Jaskoll, Tina

“…Mucoepidermoid carcinoma (MEC) is the most common malignant tumor originating in major and minor salivary glands (SGs). Although the precise multifactorial…”
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Small molecule inhibitors of the host cell COX/AREG/EGFR/ERK pathway attenuate cytomegalovirus-induced pathogenesis by Melnick, Michael, Abichaker, George, Htet, Khine, Sedghizadeh, Parish, Jaskoll, Tina

“…As with other herpesviruses, human cytomegalovirus (hCMV) has the ability to establish lifelong persistence and latent infection following primary exposure,…”
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Salivary gland branching morphogenesis: a quantitative systems analysis of the Eda/Edar/NFκB paradigm by Melnick, Michael, Phair, Robert D, Lapidot, Smadar A, Jaskoll, Tina

“…Ectodysplasin-A appears to be a critical component of branching morphogenesis. Mutations in mouse Eda or human EDA are associated with absent or hypoplastic…”
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CRTC1 expression during normal and abnormal salivary gland development supports a precursor cell origin for mucoepidermoid cancer by Jaskoll, Tina, Htet, Khine, Abichaker, George, Kaye, Frederic J., Melnick, Michael

“…Dysregulation of the transcription factor CRTC1 by a t(11;19) chromosomal rearrangement mediates the formation of mucoepidermoid salivary gland carcinoma…”
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Ectodysplasin receptor‐mediated signaling is essential for embryonic submandibular salivary gland development by Jaskoll, Tina, Zhou, Yan‐Min, Trump, Gary, Melnick, Michael

“…Hypohidrotic (anhidrotic) ectodermal dysplasia (HED), the most common of the ∼150 described ectodermal dysplasias, is a disorder characterized by abnormal…”
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Submandibular gland morphogenesis: Stage-specific expression of TGF-?/EGF, IGF, TGF-?, TNF, and IL-6 signal transduction in normal embryonic mice and the phenotypic effects of TGF-?2, TGF-?3, and EGF-r null mutations by Jaskoll, Tina, Melnick, Michael

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Sonic hedgehog signaling plays an essential role during embryonic salivary gland epithelial branching morphogenesis by Jaskoll, T., Leo, T., Witcher, D., Ormestad, M., Astorga, J., Bringas, Pablo, Carlsson, P., Melnick, M.

“…Gene targeting studies indicate that sonic hedgehog (Shh) signaling plays an essential role during craniofacial development. Because numerous mandibular…”
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Embryonic mouse submandibular salivary gland morphogenesis and the TNF/TNF‐R1 signal transduction pathway by Melnick, Michael, Chen, Haiming, Zhou, Yanmin, Jaskoll, Tina

“…TNF is a pleiotropic cytokine that modulates cell proliferation and apoptosis. The objective of the present study was to investigate the possible function(s)…”
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