Synthesis of 5‐Fluorouracil–Naproxen Conjugates as a Mutual Prodrug for Targeting Cancer Tissues

Synthesis of 5‐Fluorouracil–Naproxen Conjugates as a Mutual Prodrug for Targeting Cancer Tissues

A new 5‐fluorouracil–naproxen conjugate is synthesized as a mutual prodrug for targeting cancer tissues. The structure of the target compound and their intermediate are characterized by their melting point, IR, 1H NMR, 13C NMR, and elemental microanalysis. The cytotoxic activity is preliminarily eva...

Full description

Saved in:
Bibliographic Details
Published in:Macromolecular symposia. Vol. 401; no. 1
Main Authors: Mohammed, Mohammed Hassan, Jasim, Azhar Mehdi
Format: Journal Article
Language:English
Published: Weinheim Wiley Subscription Services, Inc 01-02-2022
Subjects:
5-Fluorouracil
Breast cancer
Cancer
cancer targeting
Conjugates
Cytotoxicity
Embryos
Fibroblasts
Lung cancer
Melting points
mutual prodrug
Naproxen
NMR
Nuclear magnetic resonance
Prodrugs
Synthesis
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A new 5‐fluorouracil–naproxen conjugate is synthesized as a mutual prodrug for targeting cancer tissues. The structure of the target compound and their intermediate are characterized by their melting point, IR, 1H NMR, 13C NMR, and elemental microanalysis. The cytotoxic activity is preliminarily evaluated using nonsmall lung cancer CRL‐2049, human breast cancer CAL‐51, and one type of normal cell line; rat embryo fibroblast cell line. The synthesized compound shows a good cytotoxic effect at the cancer cell and no significant effect at rat embryo fibroblast cell line.
ISSN:1022-1360
1521-3900
DOI:10.1002/masy.202100308