Search Results - "Jarzyna, Robert"
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Transcription Factor ChREBP Mediates High Glucose-Evoked Increase in HIF-1α Content in Epithelial Cells of Renal Proximal Tubules
Published in International journal of molecular sciences (10-12-2021)“…Hyperglycemia/diabetes appears to be accompanied by the state of hypoxia, which especially affects kidneys. The aim of the study was to elucidate the mechanism…”
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The inhibition of gluconeogenesis by gatifloxacin may contribute to its hypoglycaemic action
Published in European journal of pharmacology (10-10-2008)“…The action of gatifloxacin, the broad-spectrum fluoroquinolone antibiotic commonly used in the therapy of various bacterial infections, was investigated in…”
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3
Modulation of endothelial cell migration by extracellular nucleotides: involvement of focal adhesion kinase and phosphatidylinositol 3-kinase-mediated pathways
Published in Thrombosis and haemostasis (01-04-2005)“…Extracellular nucleotides bind to type-2 purinergic/pyrimidinergic (P2) receptors that mediate various responses, such as cell activation, proliferation and…”
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4
The inhibition of gluconeogenesis by chloroquine contributes to its hypoglycaemic action
Published in European journal of pharmacology (12-10-2001)“…The effect of chloroquine on gluconeogenesis in isolated hepatocytes and kidney-cortex tubules of rabbit has been studied. The inhibitory action of 200 μM…”
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5
Hypoxia increases the rate of renal gluconeogenesis via hypoxia-inducible factor-1-dependent activation of phosphoenolpyruvate carboxykinase expression
Published in Biochimie (01-04-2020)“…Although up to 25% of glucose released into circulation in the postabsorptive state comes from renal gluconeogenesis, the regulatory mechanisms of this process…”
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6
The impact of gluten ingestion on pathogenesis of neurological disorders
Published in Postȩpy higieny i medycyny doświadczalnej (08-05-2019)“…For many years the spectrum of gluten-related disorders had been limited only to celiac disease and its typical gastrointestinal symptoms. In the last few…”
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Physical activity in the prevention and treatment of diseases of affluence--the key role of AMP-activated protein kinase (AMPK)
Published in Postȩpy higieny i medycyny doświadczalnej (12-09-2014)“…In developed countries, we can observe an increasing number of people with obesity, type 2 diabetes, dyslipidemia, hypertension and arteriosclerosis. The main…”
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The key role of AMP-activated protein kinase (AMPK) in aging process
Published in Postępy biochemii (2016)“…Aging is one of the most extensively studied biological process and yet still some of its aspects remain elusive. It appears that AMP - activated protein…”
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Involvement of nucleotide receptors in the regulation of vascular function
Published in Postępy biochemii (2014)“…A novel function of ATP as a signal molecule was described nearly 50 years ago. Since then many receptors that could be activated via ATP, ADP, UTP, UDP and…”
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10
ERK1/2 pathway is involved in renal gluconeogenesis inhibition under conditions of lowered NADPH oxidase activity
Published in Free radical biology & medicine (01-04-2015)“…The aim of this study was to elucidate the mechanisms involved in the inhibition of renal gluconeogenesis occurring under conditions of lowered activity of…”
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11
The role of glucose transporters in human metabolic regulation
Published in Postępy biochemii (2013)“…Glucose is one of the most important sources of energy in human metabolizm. Cells absorb it by active transport (with SGLT transporters) or by facilitated…”
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12
Extracellular Nucleotides and Adenosine Independently Activate AMP-Activated Protein Kinase in Endothelial Cells: Involvement of P2 Receptors and Adenosine Transporters
Published in Circulation research (17-03-2006)“…AMP-activated protein kinase (AMPK) plays a key role in the regulation of energy homeostasis and is activated in response to cellular stress, including…”
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13
Extracellular nucleotides enhance procoagulatory profile of endothelial cells after TNFα stimulation
Published in Vascular pharmacology (01-05-2012)Get full text
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14
AMP-activated protein kinase--the key role in metabolic regulation
Published in Postępy biochemii (2006)“…AMP-activated protein kinase (AMPK) is the central component of a protein kinase cascade that acts as an energy sensor maintaining the energy balance at the…”
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Role of hypothalamic AMP-activated protein kinase in the control of food intake
Published in Postȩpy higieny i medycyny doświadczalnej (21-05-2010)“…AMP-activated kinase is an evolutionarily conserved enzyme found in every eukaryotic organism examined for its presence. It plays a critical role in the shift…”
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16
PPAR-gamma-independent inhibitory effect of rosiglitazone on glucose synthesis in primary cultured rabbit kidney-cortex tubules
Published in Biochemistry and cell biology (01-10-2008)“…Therapeutic effect of rosiglitazone has been reported to result from an improvement of insulin sensitivity and inhibition of glucose synthesis. As the latter…”
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17
Statins inhibit glucose uptake by endothelial cells by disorganization of actin cytoskeleton
Published in Vascular pharmacology (01-05-2012)Get full text
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Differential effects of selegiline on glucose synthesis in rabbit kidney-cortex tubules and hepatocytes. In vitro and in vivo studies
Published in Chemico-biological interactions (15-12-2007)“…The action of selegiline, a selective and irreversible inhibitor of monoamine oxidase B, commonly applied in the therapy of Parkinson's disease, on glucose…”
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Extracellular Nucleotides and Adenosine Independently Activate AMP-Activated Protein Kinase in Endothelial Cells. Involvement of P2 Receptors and Adenosine Transporters: AMPK activation by nucleotides and adenosine
Published in Circulation research (23-02-2006)“…AMP-activated protein kinase (AMPK) plays a key role in the regulation of energy homeostasis and is activated in response to cellular stress, including…”
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20
Chloroquine--miscellaneous properties of the antimalarial drug
Published in Postȩpy higieny i medycyny doświadczalnej (2002)“…Chloroquine is a drug with over 60 years of safe clinical use in the treatment of malaria. The multiple mechanisms of chloroquine action have appeared to be…”
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