Search Results - "Jarvis, T C"

Poliovirus RNA recombination: mechanistic studies in the absence of selection by Jarvis, T.C., Kirkegaard, K.

“…Direct and quantitative detection of recombinant RNA molecules by polymerase chain reaction (PCR) provides a novel method for studying recombination in RNA…”
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"Macromolecular crowding": thermodynamic consequences for protein-protein interactions within the T4 DNA replication complex by JARVIS, T. C, RING, D. M, DAUBE, S. S, VON HIPPEL, P. H

“…In vitro biochemical assays are typically performed using very dilute solutions of macromolecular components. On the other hand, total intracellular…”
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Structural and enzymatic studies of the T4 DNA replication system. I. Physical characterization of the polymerase accessory protein complex by JARVIS, T. C, PAUL, L. S, VON HIPPEL, P. H

“…In this study, we have investigated the structural and physical properties of the bacteriophage T4 DNA polymerase accessory proteins. We find that T4 gene 44…”
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Nuclease-Resistant Ribozymes Decrease Stromelysin mRNA Levels in Rabbit Synovium Following Exogenous Delivery to the Knee Joint by Flory, Craig M., Pavco, Pamela A., Jarvis, Thale C., Lesch, Mark E., Wincott, Francine E., Beigelman, Leonid, Hunt, Stephen W., Schrier, Denis J.

“…Catalytic RNA molecules, or ribozymes, have generated significant interest as potential therapeutic agents for controlling gene expression. Although ribozymes…”
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Structural and enzymatic studies of the T4 DNA replication system. II. ATPase properties of the polymerase accessory protein complex by JARVIS, T. C, PAUL, L. S, HOCKENSMITH, J. W, VON HIPPEL, P. H

“…In this paper we report a detailed enzymatic characterization of the interaction of the polymerase accessory protein complex of the T4 DNA replication system…”
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Stimulation of the processivity of the DNA polymerase of bacteriophage T4 by the polymerase accessory proteins. The role of ATP hydrolysis by JARVIS, T. C, NEWPORT, J. W, VON HIPPEL, P. H

“…In this paper we examine the role of the DNA polymerase accessory proteins in modulating the processivity of DNA synthesis by the bacteriophage T4-coded five…”
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Cryoelectron microscopic visualization of functional subassemblies of the bacteriophage T4 DNA replication complex by Gogol, E P, Young, M C, Kubasek, W L, Jarvis, T C, von Hippel, P H

“…A specific complex of proteins involved in bacteriophage T4 replication has been visualized by cryoelectron microscopy as distinctive structures in association…”
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Assembly of the bacteriophage T4 replication machine requires the acidic carboxy terminus of gene 32 protein by Hurley, J M, Chervitz, S A, Jarvis, T C, Singer, B S, Gold, L

“…The acidic carboxy-terminal 89-amino acid fragment of bacteriophage T4 gene 32 protein was expressed in Escherichia coli to high levels from an inducible…”
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Highly selective .kappa. opioid analgesics. Synthesis and structure-activity relationships of novel N-[(2-aminocyclohexyl)aryl]acetamide and N-[(2-aminocyclohexyl)aryloxy]acetamide derivatives by Clark, Colin R, Halfpenny, Paul R, Hill, Raymond G, Horwell, David C, Hughes, John, Jarvis, Terry C, Rees, David C, Schofield, David

“…This paper describes the synthesis, structure-activity relationships (SAR) of mu and kappa opioid binding affinities, and analgesic properties of a series of…”
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Adenovirus-mediated expression of a ribozyme to c-myb mRNA inhibits smooth muscle cell proliferation and neointima formation in vivo by Macejak, D G, Lin, H, Webb, S, Chase, J, Jensen, K, Jarvis, T C, Leiden, J M, Couture, L

“…Smooth muscle cell (SMC) proliferation is an important component of restenosis in response to injury after balloon angioplasty. Inhibition of proliferation in…”
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Optimizing the cell efficacy of synthetic ribozymes. Site selection and chemical modifications of ribozymes targeting the proto-oncogene c-myb by Jarvis, T C, Wincott, F E, Alby, L J, McSwiggen, J A, Beigelman, L, Gustofson, J, DiRenzo, A, Levy, K, Arthur, M, Matulic-Adamic, J, Karpeisky, A, Gonzalez, C, Woolf, T M, Usman, N, Stinchcomb, D T

“…Expression of the proto-oncogene c-myb is necessary for proliferation of vascular smooth muscle cells. We have developed synthetic hammerhead ribozymes that…”
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Effects of solvent and anomeric configuration upon the circular dichroism, temperature dependence of amide proton chemical shifts, amide proton exchange rates, and infrared absorption of methyl 2-acetamido-2-deoxy-D-glucopyranosides by Buffington, L. A, Blackburn, D. W, Hamilton, C. L, Jarvis, T. C, Knowles, J. J, Lodwick, P. A, McAllister, L. M, Neidhart, D. J, Serumgard, J. L

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Optimization of lipid-mediated ribozyme delivery to cells in culture by Brown, S A, Jarvis, T C

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Inhibition of vascular smooth muscle cell proliferation by ribozymes that cleave c-myb mRNA by Jarvis, T C, Alby, L J, Beaudry, A A, Wincott, F E, Beigelman, L, McSwiggen, J A, Usman, N, Stinchcomb, D T

“…Proliferation of injured smooth muscle cells contributes to the reocclusion or restenosis of coronary arteries that often occurs following angioplasty…”
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Ribozymes as Tools for Therapeutic Target Validation in Arthritis by Jarvis, Thale C, Bouhana, Karyn S, Lesch, Mark E, Brown, Suzy A, Parry, Tom J, Schrier, Denis J, Hunt, Stephen W., III, Pavco, Pamela A, Flory, Craig M

“…In this paper we describe a method for validating therapeutic gene targets in arthritic disease. Ribozymes are catalytic oligonucleotides capable of highly…”
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Spectrum of activity and mode of action of REP3123, a new antibiotic to treat Clostridium difficile infections by Critchley, Ian A., Green, Louis S., Young, Casey L., Bullard, James M., Evans, Ron J., Price, Melissa, Jarvis, Thale C., Guiles, Joseph W., Janjic, Nebojsa, Ochsner, Urs A.

“…Objectives The aim of this study was to characterize the antimicrobial profile of REP3123, a novel inhibitor of methionyl-tRNA synthetase (MetRS) in…”
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Rapid histochemistry using slow off-rate modified aptamers with anionic competition by Gupta, Shashi, Thirstrup, Derek, Jarvis, Thale C, Schneider, Daniel J, Wilcox, Sheri K, Carter, Jeff, Zhang, Chi, Gelinas, Amy, Weiss, Allison, Janjic, Nebojsa, Baird, Geoffrey S

“…Immunohistochemistry is used in both research and clinical settings to identify proteins in tissue samples. Despite the power and versatility of…”
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Using macromolecular crowding agents to identify weak interactions within DNA replication complexes by Reddy, M K, Weitzel, S E, Daube, S S, Jarvis, T C, von Hippel, P H

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Structural and Enzymatic Studies of the T4 DNA Replication System by Jarvis, T C, Paul, L S, von Hippel, P H

“…In this study, we have investigated the structural and physical properties of the bacteriophage T4 DNA polymerase accessory proteins. We find that T4 gene 44…”
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Post-synthetically Ligated Ribozymes:  An Alternative Approach to Iterative Solid-Phase Synthesis by Bellon, Laurent, Workman, Christopher T, Jarvis, Thale C, Wincott, Francine E

“…To improve the overall yield of ribozyme synthesis, a convergent approach, based on the post-synthetic formation of an amino linker between two half-ribozymes…”
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