Search Results - "Jarvi, Esa T"

Inactivation of Ribonucleotide Reductase by (E)-2‘-Fluoromethylene-2‘-deoxycytidine 5‘-Diphosphate:  A Paradigm for Nucleotide Mechanism-Based Inhibitors by van der Donk, Wilfred A, Yu, Guixue, Silva, Domingos J, Stubbe, JoAnne, McCarthy, James R, Jarvi, Esa T, Matthews, Donald P, Resvick, Robert J, Wagner, Eugene

“…Ribonucleotide reductase (RDPR) from Escherichia coli catalyzes the conversion of nucleotides to deoxynucleotides and is composed of two homodimeric subunits: …”
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Terminal difluoro olefin analogs of squalene are time-dependent inhibitors of squalene epoxidase by Moore, William R, Schatzman, Gerald L, Jarvi, Esa T, Gross, Raymond S, McCarthy, James R

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Characterization of a Substrate-Derived Radical Detected during the Inactivation of Ribonucleotide Reductase from Escherichia coli by 2‘-Fluoromethylene-2‘-deoxycytidine 5‘-Diphosphate by Gerfen, Gary J, van der Donk, Wilfred A, Yu, Guixue, McCarthy, James R, Jarvi, Esa T, Matthews, Donald P, Farrar, Christian, Griffin, Robert G, Stubbe, JoAnne

“…Ribonucleotide reductase (RDPR) from E. coli catalyzes the conversion of nucleotides to deoxynucleotides and contains an unusual tyrosyl radical−diferric…”
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Acyclic stereoselection. Part 42. 1,4- and 1,5-Stereoselection by sequential aldol addition to a .alpha.,.beta.-unsaturated aldehydes followed by Claisen rearrangement. Application to total synthesis of the vitamin E side chain and the archaebacterial C40 diol by Heathcock, Clayton H, Finkelstein, Bruce L, Jarvi, Esa T, Radel, Peggy A, Hadley, Cheri R

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Acyclic stereoselection. 14. O-alkyllactic acid esters: reagents for the stereoselective construction of erythro- and threo-.alpha.-methyl-.alpha.,.beta.-dihydroxy carbonyl compounds by Heathcock, Clayton H, Hagen, James P, Jarvi, Esa T, Pirrung, Michael C, Young, Steven D

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Preparation and characterization of 1,8,19,26-tetraoxa[8.8](2,6)naphthalenophane-3,5,21,23-tetrayne and related donut-shaped cyclophanes by Whitlock, Barbara J, Jarvi, Esa T, Whitlock, Howard W

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4'-5'-Unsaturated 5'-halogenated nucleosides. Mechanism-based and competitive inhibitors of S-adenosyl-L-homocysteine hydrolase by Jarvi, Esa T, McCarthy, James R, Mehdi, Shujaath, Matthews, Donald P, Edwards, Michael L, Prakash, Nellikunja J, Bowlin, Terry L, Sunkara, Prasad S, Bey, Philippe

“…The design and synthesis of (E)- and (Z)-5'-fluoro-4',5'-didehydro-5'-deoxyadenosine (6 and 13, respectively), a new class of mechanism-based inhibitors of…”
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1,8,17,24-Tetraoxa[8.8](2,6)naphthalenophane-3,5,19,21-tetrayne-10,30-dicarboxylic acid derivatives, novel complexors of aromatic guests by Jarvi, Esa T, Whitlock, Howard W

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Acyclic stereoselection. 23. Lactaldehyde enolate equivalents by Heathcock, Clayton H, Pirrung, Michael C, Young, Steven D, Hagen, James P, Jarvi, Esa T, Badertscher, Ulrich, Marki, Hans Peter, Montgomery, Stephen H

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4'-5'-Unsaturated 5'-halogenated nucleosides. Mechanism-based and competitive inhibitors of S-adenosyl-L-homocysteine hydrolase. [Erratum to document cited in CA114(21):207657n] by Jarvi, Esa T, McCarthy, James R, Mehdi, Shujaath, Matthews, Donald P, Edwards, Michael L, Prakash, Nellikunja J, Bowlin, Terry L, Sunkara, Prasad S, Bey, Philippe

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4',5'-Unsaturated-5'-fluoro adenosine nucleosides: potent mechanism-based inhibitors of S-adenosyl-L-homocysteine hydrolase by McCarthy, James R, Jarvi, Esa T, Matthews, Donald P, Edwards, Michael L, Prakash, Nellikunja J, Bowlin, Terry L, Mehdi, Shujaath, Sunkara, Prasad S, Bey, Philippe

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Secondary amine catalysis of the oximation of acetone by Hine, Jack, Dempsey, Richard C, Evangelista, Ramon A, Jarvi, Esa T, Wilson, James M

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Selective inhibition of T cell activation by an inhibitor of S-adenosyl- L-homocysteine hydrolase by Wolos, JA, Frondorf, KA, Davis, GF, Jarvi, ET, McCarthy, JR, Bowlin, TL

“…Defects in the enzymes involved in the pathway of S-adenosylmethionine (AdoMet) metabolism, or inhibition of those enzymes, results in profound…”
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Antimalarial activity of a 4',5'-unsaturated 5'-fluoroadenosine mechanism-based inhibitor of S-adenosyl-L-homocysteine hydrolase by Bitonti, A J, Baumann, R J, Jarvi, E T, McCarthy, J R, McCann, P P

“…A 4',5'-unsaturated 5'-fluoroadenosine inhibitor of S-adenosyl-L-homocysteine hydrolase (SAH hydrolase; EC 3.3.1.1), MDL 28842, was found to inhibit markedly…”
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Depletion of estrogen receptor in human breast tumor cells by a novel substituted indole that does not bind to the hormone binding domain by Bitonti, Alan J., Dumont, Jennifer A., Salituro, Francesco G., McDonald, Ian A., Jarvi, Esa T., Frey, Lisa M., Wright, Paul S., Baumann, Russell J.

“…Steroidal antiestrogens appear to have at least two major modes of action in breast cancer cells, direct antagonism of estrogen binding to its receptor and…”
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Antiretroviral activity of mechanism-based irreversible inhibitors of S-adenosylhomocysteine hydrolase by Prakash, N J, Davis, G F, Jarvi, E T, Edwards, M L, McCarthy, J R, Bowlin, T L

“…S-Adenosylhomocysteine hydrolase (AdoHcy-nase) is a key enzyme in transmethylation reactions. The objective of the present study was to examine the potential…”
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The mechanism of inhibition of S-adenosyl-L-homocysteine hydrolase by fluorine-containing adenosine analogs by Mehdi, S, Jarvi, E T, Koehl, J R, McCarthy, J R, Bey, P

“…(Z)-4',5'-Didehydro-5'-deoxy-5'-fluoroadenosine (I), 5'-deoxy-5'-difluoroadenosine (II), and 4',5'-didehydro-5'-deoxy-5'-fluoroarabinosyl-adenosine (III) are…”
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