Search Results - "Jarrett, Kelsey"

FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption by Clifford, Bethan L., Sedgeman, Leslie R., Williams, Kevin J., Morand, Pauline, Cheng, Angela, Jarrett, Kelsey E., Chan, Alvin P., Brearley-Sholto, Madelaine C., Wahlström, Annika, Ashby, Julianne W., Barshop, William, Wohlschlegel, James, Calkin, Anna C., Liu, Yingying, Thorell, Anders, Meikle, Peter J., Drew, Brian G., Mack, Julia J., Marschall, Hanns-Ulrich, Tarling, Elizabeth J., Edwards, Peter A., de Aguiar Vallim, Thomas Q.

“…FXR agonists are used to treat non-alcoholic fatty liver disease (NAFLD), in part because they reduce hepatic lipids. Here, we show that FXR activation with…”
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AAV-CRISPR Gene Editing Is Negated by Pre-existing Immunity to Cas9 by Li, Ang, Tanner, Mark R., Lee, Ciaran M., Hurley, Ayrea E., De Giorgi, Marco, Jarrett, Kelsey E., Davis, Timothy H., Doerfler, Alexandria M., Bao, Gang, Beeton, Christine, Lagor, William R.

“…Adeno-associated viral (AAV) vectors are a leading candidate for the delivery of CRISPR-Cas9 for therapeutic genome editing in vivo. However, AAV-based…”
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Somatic Editing of Ldlr With Adeno-Associated Viral-CRISPR Is an Efficient Tool for Atherosclerosis Research by Jarrett, Kelsey E, Lee, Ciaran, De Giorgi, Marco, Hurley, Ayrea, Gillard, Baiba K, Doerfler, Alexandria M, Li, Ang, Pownall, Henry J, Bao, Gang, Lagor, William R

“…OBJECTIVE—Atherosclerosis studies in Ldlr knockout mice require breeding to homozygosity and congenic status on C57BL6/J background, a process that is both…”
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CRISPR/Cas9: at the cutting edge of hepatology by Pankowicz, Francis P, Jarrett, Kelsey E, Lagor, William R, Bissig, Karl-Dimiter

“…Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 genome engineering has revolutionised biomedical science and we are standing on the…”
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A Self-Deleting AAV-CRISPR System for In Vivo Genome Editing by Li, Ang, Lee, Ciaran M, Hurley, Ayrea E, Jarrett, Kelsey E, De Giorgi, Marco, Lu, Weiqi, Balderrama, Karol S, Doerfler, Alexandria M, Deshmukh, Harshavardhan, Ray, Anirban, Bao, Gang, Lagor, William R

“…Adeno-associated viral (AAV) vectors packaging the CRISPR-Cas9 system (AAV-CRISPR) can efficiently modify disease-relevant genes in somatic tissues with high…”
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In Vivo Gene Editing in Lipid and Atherosclerosis Research by De Giorgi, Marco, Jarrett, Kelsey E, de Aguiar Vallim, Thomas Q, Lagor, William R

“…The low-density lipoprotein receptor (Ldlr) and apolipoprotein E (Apoe) germline knockout (KO) models have provided fundamental insights in lipid and…”
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In Vivo Ryr2 Editing Corrects Catecholaminergic Polymorphic Ventricular Tachycardia by Pan, Xiaolu, Philippen, Leonne, Lahiri, Satadru K, Lee, Ciaran, Park, So Hyun, Word, Tarah A, Li, Na, Jarrett, Kelsey E, Gupta, Rajat, Reynolds, Julia O, Lin, Jean, Bao, Gang, Lagor, William R, Wehrens, Xander H.T

“…RATIONALE:Autosomal-dominant mutations in ryanodine receptor type 2 (RYR2) are responsible for ≈60% of all catecholaminergic polymorphic ventricular…”
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RNF130 Regulates LDLR Availability and Plasma LDL Cholesterol Levels by Clifford, Bethan L., Jarrett, Kelsey E., Cheng, Joan, Cheng, Angela, Seldin, Marcus, Morand, Pauline, Lee, Richard, Chen, Mary, Baldan, Angel, de Aguiar Vallim, Thomas Q., Tarling, Elizabeth J.

“…Removal of circulating plasma low-density lipoprotein cholesterol (LDL-C) by the liver relies on efficient endocytosis and intracellular vesicle trafficking…”
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Depletion of essential isoprenoids and ER stress induction following acute liver-specific deletion of HMG-CoA reductase by De Giorgi, Marco, Jarrett, Kelsey E., Burton, Jason C., Doerfler, Alexandria M., Hurley, Ayrea, Li, Ang, Hsu, Rachel H., Furgurson, Mia, Patel, Kalyani R., Han, Jun, Borchers, Christoph H., Lagor, William R.

“…HMG-CoA reductase (Hmgcr) is the rate-limiting enzyme in the mevalonate pathway and is inhibited by statins. In addition to cholesterol, Hmgcr activity is also…”
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ZFP36-mediated mRNA decay regulates metabolism by Cicchetto, Andrew C., Jacobson, Elsie C., Sunshine, Hannah, Wilde, Blake R., Krall, Abigail S., Jarrett, Kelsey E., Sedgeman, Leslie, Turner, Martin, Plath, Kathrin, Iruela-Arispe, M. Luisa, de Aguiar Vallim, Thomas Q., Christofk, Heather R.

“…Cellular metabolism is tightly regulated by growth factor signaling, which promotes metabolic rewiring to support growth and proliferation. While growth…”
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Somatic genome editing with CRISPR/Cas9 generates and corrects a metabolic disease by Jarrett, Kelsey E., Lee, Ciaran M., Yeh, Yi-Hsien, Hsu, Rachel H., Gupta, Rajat, Zhang, Min, Rodriguez, Perla J., Lee, Chang Seok, Gillard, Baiba K., Bissig, Karl-Dimiter, Pownall, Henry J., Martin, James F., Bao, Gang, Lagor, William R.

“…Germline manipulation using CRISPR/Cas9 genome editing has dramatically accelerated the generation of new mouse models. Nonetheless, many metabolic disease…”
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Intestinal Deletion of 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Promotes Expansion of the Resident Stem Cell Compartment by Doerfler, Alexandria M., Han, Jun, Jarrett, Kelsey E., Tang, Li, Jain, Antrix, Saltzman, Alexander, De Giorgi, Marco, Chuecos, Marcel, Hurley, Ayrea E., Li, Ang, Morand, Pauline, Ayala, Claudia, Goodlett, David R., Malovannaya, Anna, Martin, James F., de Aguiar Vallim, Thomas Q., Shroyer, Noah, Lagor, William R.

“…The intestine occupies the critical interface between cholesterol absorption and excretion. Surprisingly little is known about the role of de novo cholesterol…”
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Hepatic nonvesicular cholesterol transport is critical for systemic lipid homeostasis by Xiao, Xu, Kennelly, John Paul, Ferrari, Alessandra, Clifford, Bethan L., Whang, Emily, Gao, Yajing, Qian, Kevin, Sandhu, Jaspreet, Jarrett, Kelsey E., Brearley-Sholto, Madelaine C., Nguyen, Alexander, Nagari, Rohith T., Lee, Min Sub, Zhang, Sicheng, Weston, Thomas A., Young, Stephen G., Bensinger, Steven J., Villanueva, Claudio J., de Aguiar Vallim, Thomas Q., Tontonoz, Peter

“…In cell models, changes in the ‘accessible’ pool of plasma membrane (PM) cholesterol are linked with the regulation of endoplasmic reticulum sterol synthesis…”
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Neuronal deficiency of ARV1 causes an autosomal recessive epileptic encephalopathy by Palmer, Elizabeth E, Jarrett, Kelsey E, Sachdev, Rani K, Al Zahrani, Fatema, Hashem, Mais Omar, Ibrahim, Niema, Sampaio, Hugo, Kandula, Tejaswi, Macintosh, Rebecca, Gupta, Rajat, Conlon, Donna M, Billheimer, Jeffrey T, Rader, Daniel J, Funato, Kouichi, Walkey, Christopher J, Lee, Chang Seok, Loo, Christine, Brammah, Susan, Elakis, George, Zhu, Ying, Buckley, Michael, Kirk, Edwin P, Bye, Ann, Alkuraya, Fowzan S, Roscioli, Tony, Lagor, William R

“…We report an individual who presented with severe neurodevelopmental delay and an intractable infantile-onset seizure disorder. Exome sequencing identified a…”
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Abstract 149: Manipulating Bile Acid Production Using Genome Editing To Modulate Cardio-metabolic Disease by Jarrett, Kelsey E, Tarling, Elizabeth J, Vallim, Thomas A

“…Abstract only Cardiovascular disease (CVD) remains the leading cause of death in the United States, in part due to consumption of a high cholesterol Western…”
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Abstract 162: Post-transcriptional Regulation Of FGF21 In Obesity And Metabolism by Schmidt, Heidi M, Jarrett, Kelsey E, Rubert, Gabriella, Steel, Michelle, Cheng, Angela, Tarling, Elizabeth J, Vallim, Thomas A

“…Abstract only Imbalances in energy intake and expenditure are the leading cause of the dramatic surge in obesity and cardiovascular disease affecting >60% of…”
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Abstract 2004: Sex Differences In Bile Acid Metabolism Impact Cholesterol Homeostasis And Cardiovascular Disease by Jarrett, Kelsey E, Schmidt, Heidi, Chan, Alvin, Sholto, Madelaine C, Cheng, Angela, Steel, Michelle, Taveras, Maria, Tarling, Elizabeth J, Vallim, Thomas A

“…Abstract only Cardiovascular disease (CVD) remains the leading cause of death in the United States for both men and women, despite cholesterol-lowering drugs…”
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Abstract 123: Intestinal Deletion Of 3-hydroxy-3-methylglutaryl-coenzyme A Reductase Promotes Expansion Of The Resident Stem Cell Compartment by Doerfler, Alexandria M, Han, Jun, Tang, Li, De Giorgi, Marco, Jarrett, Kelsey E, Hurley, Ayrea, Li, Ang, Chuecos, Marcel, Morand, Pauline, Ayala, Claudia, Martin, James F, Goodlett, David R, Vallim, Thomas A, Shroyer, Noah, Lagor, William R

“…Abstract only While the intestine is the critical interface between cholesterol absorption and excretion, surprisingly little is known about the role of de…”
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Abstract 216: Modeling Statin Hepatotoxicity with Acute Liver Specific Deletion of HmgCoA Reductase by De Giorgi, Marco, Jarrett, Kelsey E, Burton, Jason C, Doerfler, Alexandria M, Hurley, Ayrea, Hsu, Rachel H, Lagor, William R

“…Abstract only Hmg-CoA Reductase (Hmgcr) catalyzes the conversion of Hmg-CoA to mevalonate, which is the rate-limiting step in the cholesterol biosynthetic…”
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Intestinal Deletion of 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Promotes Expansion of the Resident Stem Cell Compartment by Doerfler, Alexandria M., Han, Jun, Jarrett, Kelsey E., Tang, Li, Jain, Antrix, Saltzman, Alexander, De Giorgi, Marco, Chuecos, Marcel, Hurley, Ayrea E., Li, Ang, Morand, Pauline, Ayala, Claudia, Goodlett, David R., Malovannaya, Anna, Martin, James F., de Aguiar Vallim, Thomas Q., Shroyer, Noah, Lagor, William R.

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