Search Results - "Jarman, Michael"

Isothiazolones as inhibitors of PCAF and p300 histone acetyltransferase activity by Stimson, Lindsay, Rowlands, Martin G, Newbatt, Yvette M, Smith, Nicola F, Raynaud, Florence I, Rogers, Paul, Bavetsias, Vassilios, Gorsuch, Stephen, Jarman, Michael, Bannister, Andrew, Kouzarides, Tony, McDonald, Edward, Workman, Paul, Aherne, G Wynne

“…Histone acetylation plays an important role in regulating the chromatin structure and is tightly regulated by two classes of enzyme, histone acetyltransferases…”
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A Customizable Suite of Methods to Sequence and Annotate Cattle Antibodies by Ramirez Valdez, Kristel, Nzau, Benjamin, Dorey-Robinson, Daniel, Jarman, Michael, Nyagwange, James, Schwartz, John C, Freimanis, Graham, Steyn, Angela W, Warimwe, George M, Morrison, Liam J, Mwangi, William, Charleston, Bryan, Bonnet-Di Placido, Marie, Hammond, John A

“…Studying the antibody response to infection or vaccination is essential for developing more effective vaccines and therapeutics. Advances in high-throughput…”
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Design, synthesis and biological evaluation of 6-pyridylmethylaminopurines as CDK inhibitors by Wilson, Stuart C., Atrash, Butrus, Barlow, Clare, Eccles, Susan, Fischer, Peter M., Hayes, Angela, Kelland, Lloyd, Jackson, Wayne, Jarman, Michael, Mirza, Amin, Moreno, Javier, Nutley, Bernard P., Raynaud, Florence I., Sheldrake, Peter, Walton, Mike, Westwood, Robert, Whittaker, Steven, Workman, Paul, McDonald, Edward

“…The cyclin-dependent kinase (CDK) inhibitor seliciclib (1, CYC202) is in phase II clinical development for the treatment of cancer. Here we describe the…”
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Discovery of genes with highly restricted expression patterns in the Drosophila wing disc using DNA oligonucleotide microarrays by Butler, Miranda J, Jacobsen, Thomas L, Cain, Donna M, Jarman, Michael G, Hubank, Michael, Whittle, J Robert S, Phillips, Roger, Simcox, Amanda

“…The Drosophila wing disc is divided along the proximaldistal axis into regions giving rise to the body wall (proximal), wing hinge (central) and wing blade…”
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Metabolism and pharmacokinetics of the cyclin-dependent kinase inhibitor R-roscovitine in the mouse by Nutley, Bernard P, Raynaud, Florence I, Wilson, Stuart C, Fischer, Peter M, Hayes, Angela, Goddard, Phyllis M, McClue, Steven J, Jarman, Michael, Lane, David P, Workman, Paul

“…R -roscovitine (seliciclib, CYC202) is a cyclin-dependent kinase inhibitor currently in phase II clinical trials in patients with cancer. Here, we describe its…”
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Inhibition of protein prenylation by metabolites of limonene by Hardcastle, IanR, Rowlands, MartinG, Moreno Barber, Amelia, Grimshaw, RachelM, Mohan, MukeshK, Nutley, BernardP, Jarman, Michael

“…The monoterpenes limonene and perillyl alcohol are undergoing clinical evaluation in cancer patients. In this paper, we report the chemical synthesis,…”
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Abstract 5867: Transcriptome profiling of ST3GAL4 and FUT7 in multiple tumor types and prognostic value in adult acute myeloid leukemia by Fogler, William E., Deng, Vince, Stewart, David, Jarman, Michael, Daminelli, Simone, Carr, Adrian, Magnani, John L.

“…Abstract E-selectin is a cell adhesion glycoprotein expressed on endothelial cells and participates in the development of environmental-mediated drug…”
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Synthesis of isothiazol-3-one derivatives as inhibitors of histone acetyltransferases (HATs) by Gorsuch, Stephen, Bavetsias, Vassilios, Rowlands, Martin G., Aherne, G. Wynne, Workman, Paul, Jarman, Michael, McDonald, Edward

“…High-throughput screening led to the identification of isothiazolones 1 and 2 as inhibitors of histone acetyltransferase (HAT) with IC50s of 3 μM and 5 μM,…”
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Novel Steroidal Inhibitors of Human Cytochrome P45017.alpha.-Hydroxylase-C17,20-lyase): Potential Agents for the Treatment of Prostatic Cancer by Potter, Gerard A, Barrie, S. Elaine, Jarman, Michael, Rowlands, Martin G

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Analogs of aminoglutethimide: selective inhibition of aromatase by Foster, Allan B, Jarman, Michael, Leung, Chui Sheung, Rowlands, Martin G, Taylor, Grahame N

“…In exploring further the structural features that influence the relative efficacy of analogues of aminoglutethimide [1,…”
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The metabolism of N-nitrosomorpholine by rat liver microsomes and its oxidation by the Fenton system by Jarman, M, Manson, D

“…The metabolism of N-nitrosomorpholine by rat liver microsomes gave acetaldehyde, formaldehyde, glyoxal and N-nitroso-2-hydroxymorpholine. Oxidation of…”
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Case report: primary osteonecrosis associated with thrombophilia-hypofibrinolysis and worsened by testosterone therapy by Jarman, Michael Ian, Lee, Kevin, Kanevsky, Ariel, Min, Sarah, Schlam, Ilana, Mahida, Chris, Huda, Ali, Milgrom, Alexander, Goldenberg, Naila, Glueck, Charles J, Wang, Ping

“…Familial and acquired thrombophilia are often etiologic for idiopathic hip and jaw osteonecrosis (ON), and testosterone therapy (TT) can interact with…”
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Treatment of Severe Hypertriglyceridemia (500 to >/= 2000 mg/dL) in 636 Patients by Jarman, Michael, Rothschild, Matan, MD, Lee, Kevin, MD, Schlam, Ilana, MD, Mahida, Chris, MD, Makadia, Frini, MD, Milgrom, Alexander, MD, Min, Sarah, MD, Huda, Ali, MD, Goldenburg, Naila, MD, Wang, Ping, PhD, Glueck, C.J., MD

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The 16,17-Double Bond Is Needed for Irreversible Inhibition of Human Cytochrome P45017 α by Abiraterone (17-(3-Pyridyl)androsta-5,16-dien-3β-ol) and Related Steroidal Inhibitors by Jarman, Michael, Barrie, S. Elaine, Llera, Jose M

“…Abiraterone (17-(3-pyridyl)androsta-5,16-dien-3β-ol, 1) is a potent inhibitor (IC50 4 nM for hydroxylase) of human cytochrome P45017 α. To assist in studies of…”
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Novel steroidal inhibitors of human cytochrome P45017α (17α-hydroxylase-C17,20-lyase) : potential agents for the treatment of prostatic cancer by POTTER, G. A, BARRIE, S. E, JARMAN, M, ROWLANDS, M. G

“…Steroidal compounds having a 17-(3-pyridyl) substituent together with a 16,17-double bond have been synthesized, using a palladium-catalyzed cross-coupling…”
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Some studies of the active intermediates formed in the microsomal metabolism of cyclophosphamide and isophosphamide by Connors, T A, Cox, P J, Farmer, P B, Foster, A B, Jarman, M

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Phase I and pharmacokinetic study of D-limonene in patients with advanced cancer by VIGUSHIN, D. M, POON, G. K, BODDY, A, ENGLISH, J, HALBERT, G. W, PAGONIS, C, JARMAN, M, COOMBES, R. C

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Culture and economy in the north Italian Neolithic by Jarman, Michael

“…This paper discusses economic change in northern Italy in the 5th to 2nd millennium B.C. as a basis for reconsidering the nature and importance of Neolithic…”
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Synthesis of 6,8-substituted-5,7-difluoro-3,4-dihydro-1H-quinoxalin-2-ones via reductive cyclisation of 2,4,6-substituted-3,5-difluoronitrobenzenes by Holland, Richard J., Hardcastle, Ian R., Jarman, Michael

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A mechanistic hypothesis for DNA adduct formation by tamoxifen following hepatic oxidative metabolism by Potter, G A, McCague, R, Jarman, M

“…A mechanism for the generation of electrophilic alkylating agents from tamoxifen by hepatic alpha-oxidation of its ethyl group is presented which accounts for…”
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