Search Results - "Jares, P."

Clinical impact of the subclonal architecture and mutational complexity in chronic lymphocytic leukemia by Nadeu, F, Clot, G, Delgado, J, Martín-García, D, Baumann, T, Salaverria, I, Beà, S, Pinyol, M, Jares, P, Navarro, A, Suárez-Cisneros, H, Aymerich, M, Rozman, M, Villamor, N, Colomer, D, González, M, Alcoceba, M, Terol, M J, Navarro, B, Colado, E, Payer, ÁR, Puente, X S, López-Otín, C, López-Guillermo, A, Enjuanes, A, Campo, E

“…Genome studies of chronic lymphocytic leukemia (CLL) have revealed the remarkable subclonal heterogeneity of the tumors, but the clinical implications of this…”
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KRAS mutation testing for predicting response to anti-EGFR therapy for colorectal carcinoma: proposal for an European quality assurance program by van Krieken, J. H. J. M., Jung, A., Kirchner, T., Carneiro, F., Seruca, R., Bosman, F. T., Quirke, P., Fléjou, J. F., Plato Hansen, T., de Hertogh, G., Jares, P., Langner, C., Hoefler, G., Ligtenberg, M., Tiniakos, D., Tejpar, S., Bevilacqua, G., Ensari, A.

“…Novel therapeutic agents targeting the epidermal growth factor receptor (EGFR) have improved outcomes for patients with colorectal carcinoma. However, these…”
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NOTCH1 mutations identify a genetic subgroup of chronic lymphocytic leukemia patients with high risk of transformation and poor outcome by Villamor, N, Conde, L, Martínez-Trillos, A, Cazorla, M, Navarro, A, Beà, S, López, C, Colomer, D, Pinyol, M, Aymerich, M, Rozman, M, Abrisqueta, P, Baumann, T, Delgado, J, Giné, E, González-Díaz, M, Hernández, J M, Colado, E, Payer, A R, Rayon, C, Navarro, B, José Terol, M, Bosch, F, Quesada, V, Puente, X S, López-Otín, C, Jares, P, Pereira, A, Campo, E, López-Guillermo, A

“…NOTCH1 has been found recurrently mutated in a subset of patients with chronic lymphocytic leukemia (CLL). To analyze biological features and clinical impact…”
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Immune signatures identify three immune clusters in mCRC, with potential clinical implications by Pedrosa, L., Moreno, R., Esposito, F., Jares, P., Cuatrecasas, M., Pineda, E., Español, M., Paré, L., De la Iglesia, N., Benitez, D., Camps, J., Church, S., Cascante, M., Thomson, T., Prat, A., Maurel, J.

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Exploratory analysis of clinical benefit of ipilimumab and nivolumab treatment in patients with metastatic melanoma from a single institution by Vila, C. M., Moreno, F. A., Estébanez, M. M., Ares, G. R., Villacampa, G., Dashti, P., Oberoi, H. S., Martin-Huertas, R., Jares, P., Alos, L., Teixido, C., Rull, R., Sanchez, M., Malvehy, J., Carcelero, E., Valduvieco, I., Fernandez, A. A.

“…Purpose We retrospectively analysed overall survival (OS) and potential predictive biomarkers of OS in patients with metastatic melanoma treated with…”
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Unraveling the clinicopathological and molecular changes induced by neoadjuvant chemotherapy and endocrine therapy in hormone receptor-positive/HER2-low and HER2-0 breast cancer by Schettini, F., Nucera, S., Brasó-Maristany, F., De Santo, I., Pascual, T., Bergamino, M., Galván, P., Conte, B., Seguí, E., García Fructuoso, I., Gómez Bravo, R., Rivera, P., Rodríguez, A.B., Martínez-Sáez, O., Ganau, S., Sanfeliu, E., González-Farre, B., Vidal Losada, M.J., Adamo, B., Cebrecos, I., Mension, E., Oses, G., Jares, P., Vidal-Sicart, S., Mollà, M., Muñoz, M., Prat, A.

“…The characterization and comparison of gene expression and intrinsic subtype (IS) changes induced by neoadjuvant chemotherapy (NACT) and endocrine therapy in…”
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P1295: DECIPHERING THE ROLE OF MSI2 AS A REGULATOR OF MANTLE CELL LYMPHOMA STEM‐LIKE PROPERTIES by Sureda‐Gómez, M., Balsas, P., Rodríguez, M.‐L., Nadeu, F., De Bolòs, A., Eguileor, Á., Kulis, M., Castellano, G., Giné, E., Demajo, S., Martín‐Subero, J. I., Jares, P., Campo, E., Amador, V.

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GENE MUTATIONS AND COPY NUMBER ALTERATIONS (CNA) PREDICT FOR EARLY FAILURE IN PATIENTS WITH DIFFUSE LARGE B‐CELL LYMPHOMA (DLBCL) TREATED WITH R‐CHOP by Dlouhy, I., Karube, K., Enjuanes, A., Salaverría, I., Pérez‐Galán, P., Jares, P., Martín‐García, D., Nadeu, F., Rivas‐Delgado, A., Rovira, J., Gonzalez, B., Mozos, A., Clot, G., Sancho, J.M., Salar, A., Mercadal, S., Escola, L., Briones, J., Colomo, L., Alcoceba, M., Valera, A., Campo, E., López‐Guillermo, A.

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The Cdc7/Dbf4 protein kinase: target of the S phase checkpoint? by Jares, Pedro, Donaldson, Anne, Blow, J Julian

“…Cdc7/Dbf4 is a protein kinase that is required for the initiation of DNA replication in eukaryotes. Recent work has provided new clues to the role that…”
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KRAS mutation testing for predicting response to anti-EGFR therapy for colorectal carcinoma: proposal for an European quality assurance program by van Krieken, J. H. J. M., Jung, A., Kirchner, T., Carneiro, F., Seruca, R., Bosman, F. T., Quirke, P., Fléjou, J. F., Hansen, T. Plato, de Hertogh, G., Jares, P., Langner, C., Hoefler, G., Ligtenberg, M., Tiniakos, D., Tejpar, S., Bevilacqua, G., Ensari, A.

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Constitutive nuclear factor‐κB activity in human upper airway tissues and nasal epithelial cells by Ramis, I., Bioque, G., Lorente, J., Jares, P., Quesada, P., Roselló‐Catafau, J., Gelpí, E, Bulbena, O

“…Respiratory epithelial cells are actively involved in the host defence and inflammatory reactions of the airways. Nuclear factor‐κB (NF‐κB) is a transcription…”
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Integrating genomic alterations in diffuse large B-cell lymphoma identifies new relevant pathways and potential therapeutic targets by Karube, K, Enjuanes, A, Dlouhy, I, Jares, P, Martin-Garcia, D, Nadeu, F, Ordóñez, G R, Rovira, J, Clot, G, Royo, C, Navarro, A, Gonzalez-Farre, B, Vaghefi, A, Castellano, G, Rubio-Perez, C, Tamborero, D, Briones, J, Salar, A, Sancho, J M, Mercadal, S, Gonzalez-Barca, E, Escoda, L, Miyoshi, H, Ohshima, K, Miyawaki, K, Kato, K, Akashi, K, Mozos, A, Colomo, L, Alcoceba, M, Valera, A, Carrió, A, Costa, D, Lopez-Bigas, N, Schmitz, R, Staudt, L M, Salaverria, I, López-Guillermo, A, Campo, E

“…Genome studies of diffuse large B-cell lymphoma (DLBCL) have revealed a large number of somatic mutations and structural alterations. However, the clinical…”
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9217 DNA reparation genes in genetic and epigenetic susceptibility to Chronic Lymphocytic Leukaemia by Martin-Guerrero, I, Enjuanes, A, Bosch, F, Villamor, N, Jares, P, Richter, J, Ammerpohl, O, Siebert, R, Campo, E, Garcia-Orad, A

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Expression of retinoblastoma gene product (pRb) in mantle cell lymphomas. Correlation with cyclin D1 (PRAD1/CCND1) mRNA levels and proliferative activity by Jares, P, Campo, E, Pinyol, M, Bosch, F, Miquel, R, Fernandez, PL, Sanchez-Beato, M, Soler, F, Perez-Losada, A, Nayach, I, Mallofre, C, Piris, MA, Montserrat, E, Cardesa, A

“…Mantle cell lymphomas (MCLs) are molecularly characterized by bcl-1 rearrangement and constant cyclin D1 (PRAD-1/CCND1) gene overexpression. Cyclin D1 is a G1…”
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352P Mutations of SMAD4 and FBXW7 predict poor outcome in TP53-driven metastatic colorectal cancer by Lahoz, S., Rodriguez Hernandez, A., Fernandez-Mañas, L., Gorria, T., Zambrano, R.M., Esposito, F.M., Sauri Nadal, T., Pesantez Coronel, D.S., Riu, G., Cuatrecasas, M., Jares, P., Pedrosa, L., Pineda, E., Postigo, A., Castells, A., Prat, A., Maurel, J., Camps, J.

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140MO HER2DX genomic test in HER2-positive/hormone receptor-positive (HER2+/HR+) breast cancer (BC) treated with neoadjuvant trastuzumab (T) and pertuzumab (P): A correlative analysis from the PerELISA trial by Guarneri, V., Dieci, M.V., Griguolo, G., Pare Brunet, L., Marin, M., Miglietta, F., Bottosso, M., Giorgi, C.A., Blasco, P., Castillo, O., Galván, P., Jares, P., Puig-butille, J.A., Vivancos, A., Villagrasa Gonzalez, P., Parker, J., Perou, C.M., Conte, P.F., Prat, A.

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Stromal Gene Signatures in Large-B-Cell Lymphomas by Lenz, G, Wright, G, Dave, S.S, Xiao, W, Powell, J, Zhao, H, Xu, W, Tan, B, Goldschmidt, N, Iqbal, J, Vose, J, Bast, M, Fu, K, Weisenburger, D.D, Greiner, T.C, Armitage, J.O, Kyle, A, May, L, Gascoyne, R.D, Connors, J.M, Troen, G, Holte, H, Kvaloy, S, Dierickx, D, Verhoef, G, Delabie, J, Smeland, E.B, Jares, P, Martinez, A, Lopez-Guillermo, A, Montserrat, E, Campo, E, Braziel, R.M, Miller, T.P, Rimsza, L.M, Cook, J.R, Pohlman, B, Sweetenham, J, Tubbs, R.R, Fisher, R.I, Hartmann, E, Rosenwald, A, Ott, G, Muller-Hermelink, H.-K, Wrench, D, Lister, T.A, Jaffe, E.S, Wilson, W.H, Chan, W.C, Staudt, L.M

“…In this study, microarrays of stromal-cell RNA showed one signature that correlated with extracellular-matrix deposition and monocytic infiltration and another…”
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25P Research-based HER2DX in patients with early-stage HER2-positive (HER2+) breast cancer treated in the N9831 phase III clinical trial by Brasó-Maristany, F., Martinez Saez, O., Pare Brunet, L., Marín-Aguilera, M., Conte, P.F., Jares, P., Guarneri, V., Pascual, T., Puig-Butille, J.A., Vivancos, A., Parker, J., Villagrasa Gonzalez, P., Tolaney, S.M., Carey, L.A., Perou, C.M., Prat, A.

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Molecular Subsets of Mantle Cell Lymphoma Defined by the IGHV Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features by NAVARRO, Alba, CLOT, Guillem, PINYOL, Magda, PUIG, Xavier, PALOMERO, Jara, VEGLIANTE, Maria Carmela, AMADOR, Virgina, MARTINEZ-TRILLOS, Alejandra, STEFANCIKOVA, Lenka, WIESTNER, Adrian, WILSON, Wyndham, POTT, Christiane, ROYO, Cristina, CALASANZ, Maria José, TRIM, Nicola, ERBER, Wendy, SANDER, Birgitta, OTT, German, ROSENWALD, Andreas, COLOMER, Dolors, GINE, Eva, SIEBERT, Reiner, LOPEZ-GUILLERMO, Armando, JARES, Pedro, STAMATOPOULOS, Kostas, BEA, Sílvia, CAMPO, Elias, HADZIDIMITRIOU, Anastasia, AGATHANGELIDIS, Andreas, BIKOS, Vasilis, DARZENTAS, Nikos, PAPADAKI, Theodora, SALAVERRIA, Itziar

“…Mantle cell lymphoma (MCL) is a heterogeneous disease with most patients following an aggressive clinical course, whereas others having an indolent behavior…”
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P11.28.ATERT C228T: A NOVEL MOLECULAR INDEPENDENT PROGNOSTIC FACTOR IN PATIENTS WITH GLIOBLASTOMA IDH WILD TYPE by Gorría, T, Crous, C, Mariño, C, Hernandez, A, Sanz, C, Doménech, M, Parra, G, Esteve-Codina, A, Carrato, C, Meléndez, B, Aldecoa, I, Jares, P, González, J, Esteve, A, Cerda, G, Alameda, F, Muñoz-Mármol, A, López-Martos, R, Valduvieco, I, González-Ortiz, S, Pineda, E, Balaña, C

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