Search Results - "Jardillier, J"

Multicellular resistance: a paradigm for clinical resistance? by Desoize, Bernard, Jardillier, Jean-Claude

“…Research on resistance to cancer treatment was mainly focused for 20 years on multidrug resistance (MDR). No useful method of reversing MDR, suitable for…”
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The antileukemic alkaloid fagaronine is an inhibitor of DNA topoisomerases I and II by Larsen, A K, Grondard, L, Couprie, J, Desoize, B, Comoe, L, Jardillier, J C, Riou, J F

“…The antileukemic alkaloid, fagaronine, is a potent differentiation inducer of various hematopoietic cell lines. We show here that fagaronine is a DNA base-pair…”
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Confocal spectral imaging analysis of intracellular interactions of mitoxantrone at different phases of the cell cycle by Feofanov, A, Charonov, S, Fleury, F, Kudelina, I, Jardillier, J C, Nabiev, I

“…It is suggested that the cytotoxicity of anticancer agent mitoxantrone (MITOX) is related to a complex combination of molecular interactions which lead to…”
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Secretion of lysosomal enzymes by drug-sensitive and multiple drug-resistant cells by WARREN, L, JARDILLIER, J. C, ORDENTLICH, P

“…The multiple drug-resistant human lymphoblastic leukemic cell, CEM/VLB100, in which P-glycoprotein (P-170) is overexpressed, has a lowered content of lysosomal…”
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Piperazine derivatives of butyric acid as differentiating agents in human leukemic cells by GILLET, R, JEANNESSON, P, SEFRAOUI, H, ARNOULD-GUERIN, M.-L, KIRKIACHARIAN, S, JARDILLIER, J.-C, PIERI, F

“…Butyric acid is a potent antineoplastic agent with a well-documented differentiation activity on a wide variety of tumor cells. However, its clinical…”
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Molecular determinants of site-specific inhibition of human DNA topoisomerase I by fagaronine and ethoxidine. Relation to DNA binding by Fleury, F, Sukhanova, A, Ianoul, A, Devy, J, Kudelina, I, Duval, O, Alix, A J, Jardillier, J C, Nabiev, I

“…DNA topoisomerase (top) I inhibition activity of the natural alkaloid fagaronine (NSC157995) and its new synthetic derivative ethoxidine…”
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Production and Activation of Matrix Metalloprotease-9 (MMP-9) by HL-60 Promyelocytic Leukemia Cells by Devy, Laetitia, Noël, Agnès, Baramova, Eugénia, Bajou, Khalid, Trentesaux, Chantal, Jardillier, Jean-Claude, Foidart, Jean-Michel, Jeannesson, Pierre

“…Human promyelocytic HL-60 cells have been used as a model of acute leukemia to investigate the expression and the regulation of matrix metalloproteases (MMPs),…”
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Nuclear DNA content and chromatin texture in multidrug-resistant human leukemic cell lines by Dufer, J, Millot-Broglio, C, Oum'Hamed, Z, Liautaud-Roger, F, Joly, P, Desplaces, A, Jardillier, J C

“…Nuclear morphological alterations associated with multidrug resistance (MDR) were evaluated by image cytometry in various human leukemic cell sub-lines: 3 cell…”
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Evidence for distinct regulation processes in the aclacinomycin- and doxorubicin-mediated differentiation of human erythroleukemic cells by Morceau, Franck, Aries, Anne, Lahlil, Rachid, Devy, Laetitia, Jardillier, Jean-Claude, Jeannesson, Pierre, Trentesaux, Chantal

“…Human erythroleukemic K 562 cells were induced to differentiate along the erythroid lineage by anthracycline antitumor drugs, such as aclacinomycin (ACLA) and…”
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Sequential overexpression of LRP and MRP but not P-gp 170 in VP16-selected A549 adenocarcinoma cells by Trussardi, A, Poitevin, G, Gorisse, M C, Faroux, M J, Bobichon, H, Delvincourt, C, Jardillier, J C

“…Chemoresistance remains the major obstacle to successful therapy of lung cancer. In order to understand drug resistance mechanisms, the expression of three…”
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Increased accumulation of drugs in multidrug-resistant cells induced by liposomes by WARREN, L, JARDILLIER, J.-C, MALARSKA, A, AKELI

“…A multidrug-resistant cell such as the human lymphoblastic leukemic cell CEM/VLB100 accumulates far less vinblastine (VLB) than its drug-sensitive parent, CEM…”
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Expression, purification and DNA-cleavage activity of recombinant 68-kDa human topoisomerase I-target for antitumor drugs by Bronstein, I B, Wynne-Jones, A, Sukhanova, A, Fleury, F, Ianoul, A, Holden, J A, Alix, A J, Dodson, G G, Jardillier, J C, Nabiev, I, Wilkinson, A J

“…The gene encoding human DNA topoisomerase (topo) I, the target of numerous anticancer drugs, has been subcloned into bacterial, yeast and baculovirus-based…”
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Human DNA topoisomerase I inhibitory activities of synthetic polyamines: relation to DNA aggregation by Sukhanova, Alyona, Dêvy, Jerome, Pluot, Michel, Bradley, Jean-Claude, Vigneron, Jean-Pierre, Jardillier, Jean-Claude, Lehn, Jean-Marie, Nabiev, Igor

“…DNA aggregation by polyamines has acquired importance as a prerequisite for the cellular uptake of DNA for gene therapy. Intracellular polyamines are…”
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Activation of erythroid-specific promoters during anthracycline-induced differentiation of K562 cells by ARIES, A, TRENTESAUX, C, OTTOLENGHI, S, JARDILLIER, J.-C, JEANNESSON, P, DOUBEIKOVSKI, A

“…Anthracycline antitumor drugs such as aclacinomycin (ACM) and doxorubicin (DOX) used in subtoxic concentrations induce erythroid differentiation of the…”
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A photon calorimeter using lead tungstate crystals for the CEBAF Hall A Compton polarimeter by Neyret, D., Pussieux, T., Auger, T., Baylac, M., Burtin, E., Cavata, C., Chipaux, R., Escoffier, S., Falletto, N., Jardillier, J., Kerhoas, S., Lhuillier, D., Marie, F., Veyssière, C., Ahrens, J., Beck, R., Lang, M.

“…A new Compton polarimeter is built on the CEBAF Hall A electron beam line. Performances of 10% resolution and 1% calibration are required for the photon…”
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Partial restoration of all trans retinoic acid (ATRA) sensitivity by compactin in ATRA-resistant leukemic cells (ATRA-R HL-60) by Gueddari, Naima, Madoulet, Claudie, Lefebvre, Philippe, Berthou, Laurence, Chomienne, Christine, Jardillier, Jean Claude

“…The resistance to all trans retinoic acid (ATRA) differentiating treatment is a consequence, in most of the cases, of either increased catabolism or down…”
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Selective enhancement of Raman or fluorescence spectra of biomolecules using specifically annealed thick gold films by Strekal, Nathali, Maskevich, Alexandre, Maskevich, Sergey, Jardillier, Jean-Claude, Nabiev, Igor

“…Annealing of “thick” metal films deposited onto a smooth dielectric substrate leads to high‐order self‐organization of metal clusters on the film surface. This…”
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Enhancement of all-trans-retinoic acid efficiency in granulocytic differentiation of HL-60 cells by incorporation into low density lipoprotein by Gueddari, N, Bobichon, H, Depierreux, C, Liautaud-Roger, F, Duriez, P, Dufer, J, Jardillier, J C

“…All-trans-retinoic acid (ATRA) has been proven to lead to complete remission of acute promyelocytic leukemia by inducing differentiation into granulocytes…”
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Expression of mdr1 gene in human breast primary tumors and metastases by HENNEQUIN, E, DELVINCOURT, C, POURNY, C, JARDILLIER, J.-C

“…Expression of mdr1 gene has been evaluated in 34 tumor samples obtained from breast cancer patients who were classified according to their treatment, and…”
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Study of sodium orthovanadate as a reverser of multidrug resistance on lymphoblastic leukemic CEM/VLB100 cells by Colin, M, Madoulet, C, Baccard, N, Arsac, F, Jardillier, J C

“…The occurrence of multidrug resistance (MDR) is the major cause of failure of cancer chemotherapy. Finding a way to circumvent this problem is now a major…”
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