Search Results - "Jardetzky, T."

The soluble isoform of human FcɛRI is an endogenous inhibitor of IgE‐mediated mast cell responses by Moñino‐Romero, S., Erkert, L., Schmidthaler, K., Diesner, S. C., Sallis, B. F., Pennington, L., Jardetzky, T., Oettgen, H. C., Bohle, B., Fiebiger, E., Szépfalusi, Z.

“…Background The soluble isoform of FcɛRI, the high‐affinity IgE receptor (sFcεRI), is a protein of the IgE network with poorly defined functions. Objective To…”
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Paramyxovirus membrane fusion: Lessons from the F and HN atomic structures by Lamb, Robert A., Paterson, Reay G., Jardetzky, Theodore S.

“…Paramyxoviruses enter cells by fusion of their lipid envelope with the target cell plasma membrane. Fusion of the viral membrane with the plasma membrane…”
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Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide by Stern, Lawrence J, Brown, Jerry H, Jardetzky, Theodore S, Gorga, Joan C, Urban, Robert G, Strominger, Jack L, Wiley, Don C

“…An influenza virus peptide binds to HLA-DR1 in an extended conformation with a pronounced twist. Thirty-five per cent of the peptide surface is accessible to…”
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Identification of self peptides bound to purified HLA-B27 by Jardetzky, T. S, Lane, W. S, Robinson, R. A, Madden, D. R, Wiley, D. C

“…A pool of endogenous peptides bound to the human class I MHC molecule, HLA-B27, has been isolated. Microsequence analysis of the pool and of 11 HPLC-purified…”
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Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1 by Brown, Jerry H, Jardetzky, Theodore S, Gorga, Joan C, Stern, Lawrence J, Urban, Robert G, Strominger, Jack L, Wiley, Don C

“…The three-dimensional structure of the class II histocompatibility glycoprotein HLA-DR1 from human B-cell membranes has been determined by X-ray…”
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Virus membrane fusion proteins: biological machines that undergo a metamorphosis by Dutch, R E, Jardetzky, T S, Lamb, R A

“…Fusion proteins from a group of widely disparate viruses, including the paramyxovirus F protein, the HIV and SIV gp160 proteins, the retroviral Env protein,…”
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Membrane fusion machines of paramyxoviruses: capture of intermediates of fusion by Russell, Charles J., Jardetzky, Theodore S., Lamb, Robert A.

“…Peptides derived from heptad repeat regions adjacent to the fusion peptide and transmembrane domains of many viral fusion proteins form stable helical bundles…”
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Structure of the Fc fragment of human IgE bound to its high-affinity receptor FcεRIα by Garman, Scott C., Wurzburg, Beth A., Tarchevskaya, Svetlana S., Kinet, Jean-Pierre, Jardetzky, Theodore S.

“…The initiation of immunoglobulin-E (IgE)-mediated allergic responses requires the binding of IgE antibody to its high-affinity receptor, Fc epsilon RI…”
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Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen by Jardetzky, Theodore S, Brown, Jerry H, Gorga, Joan C, Stern, Lawrence J, Urban, Robert G, Chi, Young-in, Stauffacher, Cynthia, Strominger, Jack L, Wiley, Don C

“…The structure of a bacterial superantigen, Staphylococcus aureus enterotoxin B, bound to a human class II histocompatibility complex molecule (HLA-DR1) has…”
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Different length peptides bind to HLA-Aw68 similarly at their ends but bulge out in the middle by Guo, Hwai-Chen, Jardetzky, Theodore S, Garrettt, Thomas P. J, Lane, William S, Strominger, Jack L, Wiley, Don C

“…We report here the determination and refinement to 1.9 A resolution by X-ray cryo-crystallography the structure of HLA-Aw68. The averaged image from the…”
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Crystallographic Analysis of Endogenous Peptides Associated with HLA-DR1 Suggests a Common, Polyproline II-Like Conformation for Bound Peptides by Jardetzky, Theodore S., Brown, Jerry H., Gorga, Joan C., Stern, Lawrence J., Urban, Robert G., Strominger, Jack L., Wiley, Don C.

“…The structure of the human major histocompatibility complex (MHC) class II molecule HLA-DR1 derived from the human lymphoblastoid cell line LG-2 has been…”
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Structural Basis for Paramyxovirus-Mediated Membrane Fusion by Baker, Kent A, Dutch, Rebecca Ellis, Lamb, Robert A, Jardetzky, Theodore S

“…Paramyxoviruses are responsible for significant human mortality and disease worldwide, but the molecular mechanisms underlying their entry into host cells…”
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Peptide binding to HLA‐DR1: a peptide with most residues substituted to alanine retains MHC binding by Jardetzky, T.S., Gorga, J.C., Busch, R., Rothbard, J., Strominger, J.L., Wiley, D.C.

“…Major histocompatibility complex (MHC) glycoproteins play an important role in the development of an effective immune response. An important MHC function is…”
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Structure of the Epstein-Barr Virus gp42 Protein Bound to the MHC Class II Receptor HLA-DR1 by Mullen, Maureen M., Haan, Keith M., Longnecker, Richard, Jardetzky, Theodore S.

“…Epstein-Barr virus (EBV) causes infectious mononucleosis, establishes long-term latent infections, and is associated with a variety of human tumors. The EBV…”
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A Dual-Functional Paramyxovirus F Protein Regulatory Switch Segment: Activation and Membrane Fusion by Russell, Charles J., Kantor, Karen L., Jardetzky, Theodore S., Lamb, Robert A.

“…Many viral fusion-mediating glycoproteins couple α-helical bundle formation to membrane merger, but have different methods for fusion activation. To study…”
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Activation of a Paramyxovirus Fusion Protein Is Modulated by Inside-Out Signaling from the Cytoplasmic Tail by Waning, David L., Russell, Charles J., Jardetzky, Theodore S., Lamb, Robert A.

“…Many viruses have evolved fusion-mediating glycoproteins that couple the energy released from irreversible protein refolding to the work of membrane fusion…”
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Comparison of the P2 Specificity Pocket in Three Human Histocompatibility Antigens: HLA-A6801, HLA-A0201, and HLA-B2705 by H.-C. Guo, Madden, D. R., Silver, M. L., Jardetzky, T. S., Gorga, J. C., Strominger, J. L., Wiley, D. C.

“…Coordinates from x-ray structures of HLA-A*6801, HLA-A*0201, and HLA-B*2705 were analyzed to examine the basis for their selectivity in peptide binding. The…”
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Crystal Structure of the Human High-Affinity IgE Receptor by Garman, Scott C., Kinet, Jean-Pierre, Jardetzky, Theodore S.

“…Allergic responses result from the activation of mast cells by the human high-affinity IgE receptor. IgE-mediated allergic reactions may develop to a variety…”
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Structure of the human IgE-Fc C epsilon 3-C epsilon 4 reveals conformational flexibility in the antibody effector domains by Wurzburg, B A, Garman, S C, Jardetzky, T S

“…IgE antibodies mediate antiparasitic immune responses and the inflammatory reactions of allergy and asthma. We have solved the crystal structure of the human…”
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Interference with T Cell Receptor-HLA-DR Interactions by Epstein-Barr Virus gp42 Results in Reduced T Helper Cell Recognition by Ressing, Maaike E., van Leeuwen, Daphne, Frank A. W. Verreck, Gomez, Raquel, Heemskerk, Bianca, Toebes, Mireille, Mullen, Maureen M., Jardetzky, Theodore S., Longnecker, Richard, Schilham, Marco W., Tom H. M. Ottenhoff, Neefjes, Jacques, Schumacher, Ton N., Hutt-Fletcher, Lindsey M., Emmanuel J. H. J. Wiertz

“…Epstein-Barr virus (EBV) persists lifelong in infected hosts despite the presence of antiviral immunity. Many viral antigens are expressed during lytic…”
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