Search Results - "Jaquith, James B"

The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation by Zahreddine, Hiba Ahmad, Culjkovic-Kraljacic, Biljana, Assouline, Sarit, Gendron, Patrick, Romeo, Andrea A., Morris, Stephen J., Cormack, Gregory, Jaquith, James B., Cerchietti, Leandro, Cocolakis, Eftihia, Amri, Abdellatif, Bergeron, Julie, Leber, Brian, Becker, Michael W., Pei, Shanshan, Jordan, Craig T., Miller, Wilson H., Borden, Katherine L. B.

“…A new mechanism by which acute myeloid leukaemia patients become resistant to Ara-C and a newer treatment, ribavirin, is uncovered; these drugs can be…”
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Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency by Frew, Jonathan, Baradaran-Heravi, Alireza, Balgi, Aruna D, Wu, Xiujuan, Yan, Tyler D, Arns, Steve, Shidmoossavee, Fahimeh S, Tan, Jason, Jaquith, James B, Jansen-West, Karen R, Lynn, Francis C, Gao, Fen-Biao, Petrucelli, Leonard, Feldman, Howard H, Mackenzie, Ian R, Roberge, Michel, Nygaard, Haakon B

“…Frontotemporal lobar degeneration (FTLD) is a devastating and progressive disorder, and a common cause of early onset dementia. Progranulin (PGRN)…”
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Cytoprotective effects of IAPs revealed by a small molecule antagonist by Galbán, Stefanie, Hwang, Clara, Rumble, Julie M, Oetjen, Karolyn A, Wright, Casey W, Boudreault, Alain, Durkin, Jon, Gillard, John W, Jaquith, James B, Morris, Stephen J, Duckett, Colin S

“…Deregulated expression of members of the IAP (inhibitor of apoptosis) family has been identified in a wide variety of neoplastic cells, and synthetic IAP…”
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Selective JAK1 inhibitors for the treatment of inflammatory bowel disease by Nielsen, Ole Haagen, Boye, Theresa Louise, Gubatan, John, Chakravarti, Deepavali, Jaquith, James B., LaCasse, Eric C.

“…Janus kinase (JAK) inhibitors, also known as jakinibs, are third-generation oral small molecules that have expanded the therapeutic options for the management…”
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cIAP1 and cIAP2 Facilitate Cancer Cell Survival by Functioning as E3 Ligases that Promote RIP1 Ubiquitination by Bertrand, Mathieu J.M., Milutinovic, Snezana, Dickson, Kathleen M., Ho, Wai Chi, Boudreault, Alain, Durkin, Jon, Gillard, John W., Jaquith, James B., Morris, Stephen J., Barker, Philip A.

“…The inhibitor of apoptosis (IAP) family of proteins enhances cell survival through mechanisms that remain uncertain. In this report, we show that cIAP1 and…”
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Novel small molecules potentiate premature termination codon readthrough by aminoglycosides by Baradaran-Heravi, Alireza, Balgi, Aruna D, Zimmerman, Carla, Choi, Kunho, Shidmoossavee, Fahimeh S, Tan, Jason S, Bergeaud, Célia, Krause, Alexandra, Flibotte, Stéphane, Shimizu, Yoko, Anderson, Hilary J, Mouly, Vincent, Jan, Eric, Pfeifer, Tom, Jaquith, James B, Roberge, Michel

“…Nonsense mutations introduce premature termination codons and underlie 11% of genetic disease cases. High concentrations of aminoglycosides can restore gene…”
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Targeting the inhibitor of Apoptosis Protein BIR3 binding domains by Jaquith, James B

“…The Inhibitor of Apoptosis Proteins (IAPs) play a critical role in the regulation of cellular apoptosis and cytokine signaling. IAP family members include…”
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Novel spirothiazamenthane inhibitors of the influenza A M2 proton channel by Arns, Steve, Balgi, Aruna D., Shimizu, Yoko, Pfeifer, Tom A., Kumar, Nag, Shidmoossavee, Fahimeh S., Sun, Sharon, Tai, Sheldon S.-H., Agafitei, Olga, Jaquith, James B., Bourque, Elyse, Niikura, Masahiro, Roberge, Michel

“…The development of treatments for influenza that inhibit the M2 proton channel without being susceptible to the widespread resistance mechanisms associated…”
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Asymmetric Induction in the Diels-Alder Reaction Catalyzed by Chiral Metallocene Triflate Complexes: Dramatic Effect of Solvent Polarity by Jaquith, James B, Guan, Jinying, Wang, Shaotian, Collins, Scott

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Asymmetric Synthesis of the Highly Methylated Tryptophan Portion of the Hemiasterlin Tripeptides by Reddy, Ranga, Jaquith, James B, Neelagiri, Venugopal Rao, Saleh-Hanna, Sherine, Durst, Tony

“…The asymmetric synthesis of the methylated tryptophan portion of hemiasterlin peptides is described. The key reactions are a SnCl4-mediated ring opening of…”
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Asymmetric Synthesis of the Highly Methylated Tryptophan Portion of the Hemiasterlin Tripeptides by Reddy, Ranga, Jaquith, James B, Neelagiri, Venugopal Rao, Lalonde, Mathieu, Saleh-Hanna, Sherine, Durst, Tony

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Diels−Alder Reactions of Oxazolidinone Dienophiles Catalyzed by Zirconocene Bis(triflate) Catalysts:  Mechanism for Asymmetric Induction by Jaquith, James B, Levy, Christopher J, Bondar, Georgiy V, Wang, Shaotian, Collins, Scott

“…The Diels−Alder cycloaddition reaction between enoyl−oxazolidinones 3 and dienes is efficiently catalyzed by zirconocene bis(triflate) catalysts (4 and 8) in…”
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Asymmetric Catalysis of the Diels−Alder Reaction Using Dicationic Zirconocene Complexes by Bondar, Georgiy V, Aldea, Raluca, Levy, Christopher J, Jaquith, James B, Collins, Scott

“…Enantio- and diastereoselective Diels−Alder reactions between dienophiles 1 and cyclopentadiene are catalyzed by a chiral, dicationic complex formed on…”
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