Search Results - "Japtok, Lukasz"

Inflammatory cells, ceramides, and expression of proteases in perivascular adipose tissue adjacent to human abdominal aortic aneurysms by Folkesson, Maggie, PhD, Vorkapic, Emina, MSc, Gulbins, Erich, MD, Japtok, Lukasz, PhD, Kleuser, Burkhard, PhD, Welander, Martin, MD, Länne, Toste, MD, Wågsäter, Dick, PhD

“…Background Abdominal aortic aneurysm (AAA) is a deadly irreversible weakening and distension of the abdominal aortic wall. The pathogenesis of AAA remains…”
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The ceramide kinase inhibitor NVP‐231 inhibits breast and lung cancer cell proliferation by inducing M phase arrest and subsequent cell death by Pastukhov, Oleksandr, Schwalm, Stephanie, Zangemeister‐Wittke, Uwe, Fabbro, Doriano, Bornancin, Frederic, Japtok, Lukasz, Kleuser, Burkhard, Pfeilschifter, Josef, Huwiler, Andrea

“…Background and Purpose Ceramide kinase (CerK) catalyzes the generation of ceramide‐1‐phosphate which may regulate various cellular functions, including…”
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Involvement of Sphingosine 1-Phosphate in Palmitate-Induced Non-Alcoholic Fatty Liver Disease by Al Fadel, Frdoos, Fayyaz, Susann, Japtok, Lukasz, Kleuser, Burkhard

“…Background/Aims: Ectopic lipid accumulation in hepatocytes has been identified as a risk factor for the progression of liver fibrosis and is strongly…”
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Involvement of sphingosine 1-phosphate in palmitate-induced insulin resistance of hepatocytes via the S1P2 receptor subtype by Fayyaz, Susann, Henkel, Janin, Japtok, Lukasz, Krämer, Stephanie, Damm, Georg, Seehofer, Daniel, Püschel, Gerhard P., Kleuser, Burkhard

“…Aims/hypothesis Enhanced plasma levels of NEFA have been shown to induce hepatic insulin resistance, which contributes to the development of type 2 diabetes…”
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Sphingosine-1-phosphate exhibits anti-proliferative and anti-inflammatory effects in mouse models of psoriasis by Schaper, Katrin, Dickhaut, Jeannette, Japtok, Lukasz, Kietzmann, Manfred, Mischke, Reinhard, Kleuser, Burkhard, Bäumer, Wolfgang

“…Abstract Background It has been indicated that the sphingolipid sphingosine-1-phosphate (S1P) restrains the ability of dendritic cells to migrate to lymph…”
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Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosa by Pewzner‐Jung, Yael, Tavakoli Tabazavareh, Shaghayegh, Grassmé, Heike, Becker, Katrin Anne, Japtok, Lukasz, Steinmann, Jörg, Joseph, Tammar, Lang, Stephan, Tuemmler, Burkhard, Schuchman, Edward H, Lentsch, Alex B, Kleuser, Burkhard, Edwards, Michael J, Futerman, Anthony H, Gulbins, Erich

“…Cystic fibrosis patients and patients with chronic obstructive pulmonary disease, trauma, burn wound, or patients requiring ventilation are susceptible to…”
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A sphingolipid mechanism for behavioral extinction by Huston, Joseph P., Kornhuber, Johannes, Mühle, Christiane, Japtok, Lukasz, Komorowski, Mara, Mattern, Claudia, Reichel, Martin, Gulbins, Erich, Kleuser, Burkhard, Topic, Bianca, De Souza Silva, Maria A., Müller, Christian P.

“…Reward‐dependent instrumental behavior must continuously be re‐adjusted according to environmental conditions. Failure to adapt to changes in reward…”
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Regulation of hematogenous tumor metastasis by acid sphingomyelinase by Carpinteiro, Alexander, Becker, Katrin Anne, Japtok, Lukasz, Hessler, Gabriele, Keitsch, Simone, Požgajovà, Miroslava, Schmid, Kurt W, Adams, Constantin, Müller, Stefan, Kleuser, Burkhard, Edwards, Michael J, Grassmé, Heike, Helfrich, Iris, Gulbins, Erich

“…Metastatic dissemination of cancer cells is the ultimate hallmark of malignancy and accounts for approximately 90% of human cancer deaths. We investigated the…”
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Chemokine Receptors, CXCR1 and CXCR2, Differentially Regulate Exosome Release in Hepatocytes by Nojima, Hiroyuki, Konishi, Takanori, Freeman, Christopher M, Schuster, Rebecca M, Japtok, Lukasz, Kleuser, Burkhard, Edwards, Michael J, Gulbins, Erich, Lentsch, Alex B

“…Exosomes are small membrane vesicles released by different cell types, including hepatocytes, that play important roles in intercellular communication. We have…”
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Sphingosine 1-phosphate modulates antigen capture by murine Langerhans cells via the S1P2 receptor subtype by Japtok, Lukasz, Schaper, Katrin, Bäumer, Wolfgang, Radeke, Heinfried H, Jeong, Se Kyoo, Kleuser, Burkhard

“…Dendritic cells (DCs) play a pivotal role in the development of cutaneous contact hypersensitivity (CHS) and atopic dermatitis as they capture and process…”
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Identification of functional lipid metabolism biomarkers of brown adipose tissue aging by Gohlke, Sabrina, Zagoriy, Vyacheslav, Cuadros Inostroza, Alvaro, Méret, Michaël, Mancini, Carola, Japtok, Lukasz, Schumacher, Fabian, Kuhlow, Doreen, Graja, Antonia, Stephanowitz, Heike, Jähnert, Markus, Krause, Eberhard, Wernitz, Andreas, Petzke, Klaus-Jürgen, Schürmann, Annette, Kleuser, Burkhard, Schulz, Tim J.

“…Aging is accompanied by loss of brown adipocytes and a decline in their thermogenic potential, which may exacerbate the development of adiposity and other…”
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Plasma Levels of the Bioactive Sphingolipid Metabolite S1P in Adult Cystic Fibrosis Patients: Potential Target for Immunonutrition? by Halilbasic, Emina, Fuerst, Elisabeth, Heiden, Denise, Japtok, Lukasz, Diesner, Susanne C, Trauner, Michael, Kulu, Askin, Jaksch, Peter, Hoetzenecker, Konrad, Kleuser, Burkhard, Kazemi-Shirazi, Lili, Untersmayr, Eva

“…Recent research has linked sphingolipid (SL) metabolism with cystic fibrosis transmembrane conductance regulator (CFTR) activity, affecting bioactive lipid…”
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Sphingosine-1-Phosphate Modulates Dendritic Cell Function: Focus on Non-Migratory Effects in Vitro and in Vivo by Arlt, Olga, Schwiebs, Anja, Japtok, Lukasz, Rüger, Katja, Katzy, Elisabeth, Kleuser, Burkhard, Radeke, Heinfried H.

“…Dendritic cells (DCs) are the cutting edge in innate and adaptive immunity. The major functions of these antigen-presenting cells are the capture, endosomal…”
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Intestinal Acid Sphingomyelinase Protects From Severe Pathogen-Driven Colitis by Meiners, Jana, Palmieri, Vittoria, Klopfleisch, Robert, Ebel, Jana-Fabienne, Japtok, Lukasz, Schumacher, Fabian, Yusuf, Ayan Mohamud, Becker, Katrin A, Zöller, Julia, Hose, Matthias, Kleuser, Burkhard, Hermann, Dirk M, Kolesnick, Richard N, Buer, Jan, Hansen, Wiebke, Westendorf, Astrid M

“…Inflammatory diseases of the gastrointestinal tract are emerging as a global problem with increased evidence and prevalence in numerous countries. A…”
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Divergent Role of Sphingosine 1-Phosphate on Insulin Resistance by Fayyaz, Susann, Japtok, Lukasz, Kleuser, Burkhard

“…Insulin resistance is a complex metabolic disorder in which insulin-sensitive tissues fail to respond to the physiological action of insulin. There is a strong…”
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Chronic Psychosocial Stress in Mice Is Associated With Increased Acid Sphingomyelinase Activity in Liver and Serum and With Hepatic C16:0-Ceramide Accumulation by Reichel, Martin, Rhein, Cosima, Hofmann, Lena M, Monti, Juliana, Japtok, Lukasz, Langgartner, Dominik, Füchsl, Andrea M, Kleuser, Burkhard, Gulbins, Erich, Hellerbrand, Claus, Reber, Stefan O, Kornhuber, Johannes

“…Chronic psychosocial stress adversely affects human morbidity and is a risk factor for inflammatory disorders, liver diseases, obesity, metabolic syndrome, and…”
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Lysophosphatidic Acid Inhibits Insulin Signaling in Primary Rat Hepatocytes via the LPA3 Receptor Subtype and is Increased in Obesity by Fayyaz, Susann, Japtok, Lukasz, Schumacher, Fabian, Wigger, Dominik , Schulz, Tim Julius, Haubold, Kathrin , Gulbins, Erich, Völler, Heinz , Kleuser, Burkhard

“…Background/Aims: Obesity is a main risk factor for the development of hepatic insulin resistance and it is accompanied by adipocyte hypertrophy and an elevated…”
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Measles Virus Infection Fosters Dendritic Cell Motility in a 3D Environment to Enhance Transmission to Target Cells in the Respiratory Epithelium by Derakhshani, Shaghayegh, Kurz, Andreas, Japtok, Lukasz, Schumacher, Fabian, Pilgram, Lisa, Steinke, Maria, Kleuser, Burkhard, Sauer, Markus, Schneider-Schaulies, Sibylle, Avota, Elita

“…Transmission of measles virus (MV) from dendritic to airway epithelial cells is considered as crucial to viral spread late in infection. Therefore, pathways…”
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Sphingolipids and inflammatory diseases of the skin by Kleuser, Burkhard, Japtok, Lukasz

“…Mammalian skin protects our body against external assaults due to a well-organized skin barrier. The formation of the skin barrier is a complex process, in…”
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Sphingosine 1-phosphate lyase blockade elicits myogenic differentiation of murine myoblasts acting via Spns2/S1P2 receptor axis by Cencetti, Francesca, Bruno, Gennaro, Bernacchioni, Caterina, Japtok, Lukasz, Puliti, Elisa, Donati, Chiara, Bruni, Paola

“…The bioactive sphingolipid sphingosine 1-phosphate (S1P) has emerged in the last three decades as main regulator of key cellular processes including cell…”
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