Search Results - "Janusz, M"

Photodynamic therapy (PDT) of cancer: from local to systemic treatment by Dąbrowski, Janusz M, Arnaut, Luis G

“…Photodynamic therapy (PDT) requires a medical device, a photosensitizing drug and adequate use of both to trigger biological mechanisms that can rapidly…”
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Oxidative stress, free radicals and protein peroxides by Gebicki, Janusz M.

“…Primary free radicals generated under oxidative stress in cells and tissues produce a cascade of reactive secondary radicals, which attack biomolecules with…”
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Recent advances in strategies for overcoming hypoxia in photodynamic therapy of cancer by Pucelik, Barbara, Sułek, Adam, Barzowska, Agata, Dąbrowski, Janusz M.

“…The selectivity of photodynamic therapy (PDT) derived from the tailored accumulation of photosensitizing drug (photosensitizer; PS) in the tumor…”
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Design of Pluronic-Based Formulation for Enhanced Redaporfin-Photodynamic Therapy against Pigmented Melanoma by Pucelik, Barbara, Arnaut, Luis G, Stochel, Grażyna, Dąbrowski, Janusz M

“…The therapeutic outcome of photodynamic therapy (PDT) with redaporfin (a fluorinated sulfonamide bacteriochlorin, F2BMet or LUZ11) was improved using…”
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Photodynamic Therapy Efficacy Enhanced by Dynamics: The Role of Charge Transfer and Photostability in the Selection of Photosensitizers by Arnaut, Luis G., Pereira, Mariette M., Dąbrowski, Janusz M., Silva, Elsa F. F., Schaberle, Fábio A., Abreu, Artur R., Rocha, Luís B., Barsan, Madalina M., Urbańska, Krystyna, Stochel, Grażyna, Brett, Christopher M. A.

“…Progress in the photodynamic therapy (PDT) of cancer should benefit from a rationale to predict the most efficient of a series of photosensitizers that…”
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Synthesis and Characterization of Size- and Charge-Tunable Silver Nanoparticles for Selective Anticancer and Antibacterial Treatment by Pucelik, Barbara, Sułek, Adam, Borkowski, Mariusz, Barzowska, Agata, Kobielusz, Marcin, Dąbrowski, Janusz M

“…Advances in the research of nanoparticles (NPs) with controlled charge and size are driven by their potential application in the development of novel…”
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AnnapuRNA: A scoring function for predicting RNA-small molecule binding poses by Stefaniak, Filip, Bujnicki, Janusz M

“…RNA is considered as an attractive target for new small molecule drugs. Designing active compounds can be facilitated by computational modeling. Most of the…”
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Sensitization of TiO2 by halogenated porphyrin derivatives for visible light biomedical and environmental photocatalysis by Sułek, Adam, Pucelik, Barbara, Kuncewicz, Joanna, Dubin, Grzegorz, Dąbrowski, Janusz M.

“…[Display omitted] •New TiO2/(metallo)porphyrins hybrid materials were prepared and characterized.•Their visible light photocatalytic activity in the…”
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MODOMICS: a database of RNA modification pathways. 2021 update by Boccaletto, Pietro, Stefaniak, Filip, Ray, Angana, Cappannini, Andrea, Mukherjee, Sunandan, Purta, Elżbieta, Kurkowska, Małgorzata, Shirvanizadeh, Niloofar, Destefanis, Eliana, Groza, Paula, Avşar, Gülben, Romitelli, Antonia, Pir, Pınar, Dassi, Erik, Conticello, Silvestro G, Aguilo, Francesca, Bujnicki, Janusz M

“…Abstract The MODOMICS database has been, since 2006, a manually curated and centralized resource, storing and distributing comprehensive information about…”
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Bacteriochlorins and their metal complexes as NIR-absorbing photosensitizers: properties, mechanisms, and applications by Pucelik, Barbara, Sułek, Adam, Dąbrowski, Janusz M.

“…[Display omitted] •The review focuses on the design and characteristics of highly photoactive (metallo)bacteriochlorins.•The overview of current trends in…”
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Properties of halogenated and sulfonated porphyrins relevant for the selection of photosensitizers in anticancer and antimicrobial therapies by Pucelik, Barbara, Paczyński, Robert, Dubin, Grzegorz, Pereira, Mariette M, Arnaut, Luis G, Dąbrowski, Janusz M

“…The impact of substituents on the photochemical and biological properties of tetraphenylporphyrin-based photosensitizers for photodynamic therapy of cancer…”
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Photodynamic inactivation (PDI) as a promising alternative to current pharmaceuticals for the treatment of resistant microorganisms by Pucelik, Barbara, Dąbrowski, Janusz M

“…Although the whole world is currently observing the global battle against COVID-19, it should not be underestimated that in the next 30 years, approximately 10…”
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Photodynamic Inactivation of Bacteria with Porphyrin Derivatives: Effect of Charge, Lipophilicity, ROS Generation, and Cellular Uptake on Their Biological Activity In Vitro by Sułek, Adam, Pucelik, Barbara, Kobielusz, Marcin, Barzowska, Agata, Dąbrowski, Janusz M

“…Resistance of microorganisms to antibiotics has led to research on various therapeutic strategies with different mechanisms of action, including photodynamic…”
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MODOMICS: a database of RNA modification pathways. 2017 update by Boccaletto, Pietro, Machnicka, Magdalena A, Purta, Elzbieta, Piątkowski, Paweł, Bagiński, Błażej, Wirecki, Tomasz K, de Crécy-Lagard, Valérie, Ross, Robert, Limbach, Patrick A, Kotter, Annika, Helm, Mark, Bujnicki, Janusz M

“…Abstract MODOMICS is a database of RNA modifications that provides comprehensive information concerning the chemical structures of modified ribonucleosides,…”
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Genome-wide mapping of SARS-CoV-2 RNA structures identifies therapeutically-relevant elements by Manfredonia, Ilaria, Nithin, Chandran, Ponce-Salvatierra, Almudena, Ghosh, Pritha, Wirecki, Tomasz K, Marinus, Tycho, Ogando, Natacha S, Snijder, Eric J, van Hemert, Martijn J, Bujnicki, Janusz M, Incarnato, Danny

“…Abstract SARS-CoV-2 is a betacoronavirus with a linear single-stranded, positive-sense RNA genome, whose outbreak caused the ongoing COVID-19 pandemic. The…”
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Antioxidant activities of chitosans and its derivatives in in vitro and in vivo studies by Anraku, Makoto, Gebicki, Janusz M., Iohara, Daisuke, Tomida, Hisao, Uekama, Kaneto, Maruyama, Toru, Hirayama, Fumitoshi, Otagiri, Masaki

“…•Chitosan and its derivatives is useful for oxidative stress related diseases.•Chitosan and its derivatives resulted in reduction of hypocholesteremia and…”
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NPDock: a web server for protein-nucleic acid docking by Tuszynska, Irina, Magnus, Marcin, Jonak, Katarzyna, Dawson, Wayne, Bujnicki, Janusz M

“…Protein-RNA and protein-DNA interactions play fundamental roles in many biological processes. A detailed understanding of these interactions requires knowledge…”
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Photodynamic therapy combined with immunotherapy: recent advances and future research directions by Warszyńska, Marta, Repetowski, Paweł, Dąbrowski, Janusz M.

“…[Display omitted] Innovative anticancer therapies based on the activation of the immune system offer promise in the battle against cancers resistant to…”
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Intrinsic fluctuations of reinforcement learning promote cooperation by Barfuss, Wolfram, Meylahn, Janusz M.

“…In this work, we ask for and answer what makes classical temporal-difference reinforcement learning with ϵ -greedy strategies cooperative. Cooperating in…”
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DNAzymeBuilder, a web application for in situ generation of RNA/DNA-cleaving deoxyribozymes by Mohammadi-Arani, Razieh, Javadi-Zarnaghi, Fatemeh, Boccaletto, Pietro, Bujnicki, Janusz M, Ponce-Salvatierra, Almudena

“…Abstract Nucleic acid cleaving DNAzymes are versatile and robust catalysts that outcompete ribozymes and protein enzymes in terms of chemical stability,…”
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