Search Results - "Janus, Diana"

Development of autotaxin inhibitors: A series of zinc binding triazoles by Thomson, Christopher G., Le Grand, Darren, Dowling, Mark, Brocklehurst, Cara E., Chinn, Colin, Elphick, Lucy, Faller, Michael, Freeman, Mark, Furminger, Vikki, Gasser, Cornelia, Hamadi, Ahmed, Hardaker, Elizabeth, Head, Victoria, Hill, Johan C., Janus, Diana I., Pearce, David, Poulaud, Anne-Sophie, Stanley, Emily, Sviridenko, Lilya

“…[Display omitted] •PF-8380 has been used as a template to design a new series of ATX inhibitors.•Reduction of crystallinity was key to improving solubility of…”
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Synthesis of the Marine Sponge Derived β2-Adrenoceptor Agonist S1319 by Fairhurst, Robin A, Janus, Diana, Lawrence, Annabel

“…The marine sponge derived β2-adrenoceptor agonist S1319 has been synthesized following a six-step linear sequence. Central to the approach employed is the…”
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The Identification of Indacaterol as an Ultralong-Acting Inhaled β2-Adrenoceptor Agonist by Baur, François, Beattie, David, Beer, David, Bentley, David, Bradley, Michelle, Bruce, Ian, Charlton, Steven J, Cuenoud, Bernard, Ernst, Roland, Fairhurst, Robin A, Faller, Bernard, Farr, David, Keller, Thomas, Fozard, John R, Fullerton, Joe, Garman, Sheila, Hatto, Julia, Hayden, Claire, He, Handan, Howes, Colin, Janus, Diana, Jiang, Zhengjin, Lewis, Christine, Loeuillet-Ritzler, Frederique, Moser, Heinz, Reilly, John, Steward, Alan, Sykes, David, Tedaldi, Lauren, Trifilieff, Alexandre, Tweed, Morris, Watson, Simon, Wissler, Elke, Wyss, Daniel

“…Following a lipophilicity-based hypothesis, an 8-hydroxyquinolinone 2-aminoindan derived series of β2-adrenoceptor agonists have been prepared and evaluated…”
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The discovery of potent, orally bioavailable pyrimidine-5-carbonitrile-6-alkyl CXCR2 receptor antagonists by Porter, David W, Bradley, Michelle, Brown, Zarin, Charlton, Steven J, Cox, Brian, Hunt, Peter, Janus, Diana, Lewis, Sarah, Oakley, Paul, O'Connor, Des, Reilly, John, Smith, Nichola, Press, Neil J

“…A hit-to-lead optimisation programme was carried out on the Novartis archive screening hit, pyrimidine…”
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An investigation into the structure-activity relationships associated with the systematic modification of the β(2)-adrenoceptor agonist indacaterol by Beattie, David, Beer, David, Bradley, Michelle E, Bruce, Ian, Charlton, Steven J, Cuenoud, Bernard M, Fairhurst, Robin A, Farr, David, Fozard, John R, Janus, Diana, Rosethorne, Elizabeth M, Sandham, David A, Sykes, David A, Trifilieff, Alexandre, Turner, Katharine L, Wissler, Elke

“…The synthesis of a series of indacaterol analogues in which each of the three structural regions of indacaterol are modified in a systematic manner is…”
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An investigation into the structure–activity relationships associated with the systematic modification of the β2-adrenoceptor agonist indacaterol by Beattie, David, Beer, David, Bradley, Michelle E., Bruce, Ian, Charlton, Steven J., Cuenoud, Bernard M., Fairhurst, Robin A., Farr, David, Fozard, John R., Janus, Diana, Rosethorne, Elizabeth M., Sandham, David A., Sykes, David A., Trifilieff, Alexandre, Turner, Katharine L., Wissler, Elke

“…The synthesis of a series of indacaterol analogues in which each of the three structural regions of indacaterol are modified in a systematic manner is…”
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The identification of 7-[(R)-2-((1S,2S)-2-benzyloxycyclopentylamino)-1-hydroxyethyl]-4-hydroxybenzothiazolone as an inhaled long-acting β2-adrenoceptor agonist by Arnold, Nicola, Beattie, David, Bradley, Michelle, Brearley, Andrew, Brown, Lyndon, Charlton, Steven J., Fairhurst, Robin A., Farr, David, Fozard, John, Fullerton, Joe, Gosling, Martin, Hatto, Julia, Janus, Diana, Jones, Darryl, Jordan, Lynne, Lewis, Christine, Maas, Janet, McCarthy, Clive, Mercer, Mark, Oakman, Helen, Press, Neil, Profit, Rachel, Schuerch, Friedrich, Sykes, David, Taylor, Roger J., Trifilieff, Alexandre, Tuffnell, Andrew

“…The optimisation of two series of 4-hydroxybenzothiazolone derived β2-adrenoceptor agonists, bearing α-substituted cyclopentyl and β-phenethyl…”
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A physical properties based approach for the exploration of a 4-hydroxybenzothiazolone series of β2-adrenoceptor agonists as inhaled long-acting bronchodilators by BEATTIE, David, BRADLEY, Michelle, LEWIS, Christine, MCCARTHY, Clive, OAKMAN, Helen, STRINGER, Rowan, TAYLOR, Roger J, TUFFNELL, Andrew, BREARLEY, Andrew, CHARLTON, Steven J, CUENOUD, Bernard M, FAIRHURST, Robin A, GEDECK, Peter, GOSLING, Martin, JANUS, Diana, JONES, Darryl

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Synthesis of the marine sponge derived beta2-adrenoceptor agonist S1319 by Fairhurst, Robin A, Janus, Diana, Lawrence, Annabel

“…[reaction: see text] The marine sponge derived beta2-adrenoceptor agonist S1319 has been synthesized following a six-step linear sequence. Central to the…”
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An investigation into the structure-activity relationships associated with the systematic modification of the [beta]2-adrenoceptor agonist indacaterol by Beattie, David, Beer, David, Bradley, Michelle E, Bruce, Ian, Charlton, Steven J, Cuenoud, Bernard M, Fairhurst, Robin A, Farr, David, Fozard, John R, Janus, Diana, Rosethorne, Elizabeth M, Sandham, David A, Sykes, David A, Trifilieff, Alexandre, Turner, Katharine L, Wissler, Elke

“…The synthesis of a series of indacaterol analogues in which each of the three structural regions of indacaterol are modified in a systematic manner is…”
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Synthesis of the Marine Sponge Derived β 2 -Adrenoceptor Agonist S1319 by Fairhurst, Robin A., Janus, Diana, Lawrence, Annabel

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Long-chain formoterol analogues: an investigation into the effect of increasing amino-substituent chain length on the β 2-adrenoceptor activity by Alikhani, Vahid, Beer, David, Bentley, David, Bruce, Ian, Cuenoud, Bernard M., Fairhurst, Robin A., Gedeck, Peter, Haberthuer, Sandra, Hayden, Claire, Janus, Diana, Jordan, Lynne, Lewis, Christine, Smithies, Kirsty, Wissler, Elke

“…[Display omitted] The synthesis of a series of long-chain formoterol analogues in which the terminal ether residue of the β-phenethyl-amino-substituent has…”
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A physical properties based approach for the exploration of a 4-hydroxybenzothiazolone series of β 2-adrenoceptor agonists as inhaled long-acting bronchodilators by Beattie, David, Bradley, Michelle, Brearley, Andrew, Charlton, Steven J., Cuenoud, Bernard M., Fairhurst, Robin A., Gedeck, Peter, Gosling, Martin, Janus, Diana, Jones, Darryl, Lewis, Christine, McCarthy, Clive, Oakman, Helen, Stringer, Rowan, Taylor, Roger J., Tuffnell, Andrew

“…The chiral synthesis of a 4-hydroxybenzothiazolone based series of β 2-adrenoceptor agonists is described. Using this methodology a library of N-substituted…”
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The Identification of Indacaterol as an Ultralong-Acting Inhaled β 2 -Adrenoceptor Agonist by Baur, François, Beattie, David, Beer, David, Bentley, David, Bradley, Michelle, Bruce, Ian, Charlton, Steven J., Cuenoud, Bernard, Ernst, Roland, Fairhurst, Robin A., Faller, Bernard, Farr, David, Keller, Thomas, Fozard, John R., Fullerton, Joe, Garman, Sheila, Hatto, Julia, Hayden, Claire, He, Handan, Howes, Colin, Janus, Diana, Jiang, Zhengjin, Lewis, Christine, Loeuillet-Ritzler, Frederique, Moser, Heinz, Reilly, John, Steward, Alan, Sykes, David, Tedaldi, Lauren, Trifilieff, Alexandre, Tweed, Morris, Watson, Simon, Wissler, Elke, Wyss, Daniel

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A physical properties based approach for the exploration of a 4-hydroxybenzothiazolone series of beta2-adrenoceptor agonists as inhaled long-acting bronchodilators by Beattie, David, Bradley, Michelle, Brearley, Andrew, Charlton, Steven J, Cuenoud, Bernard M, Fairhurst, Robin A, Gedeck, Peter, Gosling, Martin, Janus, Diana, Jones, Darryl, Lewis, Christine, McCarthy, Clive, Oakman, Helen, Stringer, Rowan, Taylor, Roger J, Tuffnell, Andrew

“…The chiral synthesis of a 4-hydroxybenzothiazolone based series of beta(2)-adrenoceptor agonists is described. Using this methodology a library of…”
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Long-chain formoterol analogues: an investigation into the effect of increasing amino-substituent chain length on the beta2-adrenoceptor activity by Alikhani, Vahid, Beer, David, Bentley, David, Bruce, Ian, Cuenoud, Bernard M, Fairhurst, Robin A, Gedeck, Peter, Haberthuer, Sandra, Hayden, Claire, Janus, Diana, Jordan, Lynne, Lewis, Christine, Smithies, Kirsty, Wissler, Elke

“…The synthesis of a series of long-chain formoterol analogues in which the terminal ether residue of the beta-phenethyl-amino-substituent has been extended…”
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Long-chain formoterol analogues: an investigation into the effect of increasing amino-substituent chain length on the β2-adrenoceptor activity by ALIKHANI, Vahid, BEER, David, JORDAN, Lynne, LEWIS, Christine, SMITHIES, Kirsty, WISSLER, Elke, BENTLEY, David, BRUCE, Ian, CUENOUD, Bernard M, FAIRHURST, Robin A, GEDECK, Peter, HABERTHUER, Sandra, HAYDEN, Claire, JANUS, Diana

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The identification of indacaterol as an ultralong-acting inhaled beta2-adrenoceptor agonist by Baur, François, Beattie, David, Beer, David, Bentley, David, Bradley, Michelle, Bruce, Ian, Charlton, Steven J, Cuenoud, Bernard, Ernst, Roland, Fairhurst, Robin A, Faller, Bernard, Farr, David, Keller, Thomas, Fozard, John R, Fullerton, Joe, Garman, Sheila, Hatto, Julia, Hayden, Claire, He, Handan, Howes, Colin, Janus, Diana, Jiang, Zhengjin, Lewis, Christine, Loeuillet-Ritzler, Frederique, Moser, Heinz, Reilly, John, Steward, Alan, Sykes, David, Tedaldi, Lauren, Trifilieff, Alexandre, Tweed, Morris, Watson, Simon, Wissler, Elke, Wyss, Daniel

“…Following a lipophilicity-based hypothesis, an 8-hydroxyquinolinone 2-aminoindan derived series of beta(2)-adrenoceptor agonists have been prepared and…”
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Design and Synthesis of Thrombin Inhibitors:  Analogues of MD-805 with Reduced Stereogenicity and Improved Potency by Brundish, Derek, Bull, Alice, Donovan, Vera, Fullerton, Joseph D, Garman, Sheila M, Hayler, Judy F, Janus, Diana, Kane, Peter D, McDonnell, Mark, Smith, Garrick P, Wakeford, Robert, Walker, Clive V, Howarth, Graham, Hoyle, William, Allen, Mark C, Ambler, John, Butler, Keith, Talbot, Mark D

“…Mitsubishi's MD-805, a potent and selective inhibitor of thrombin which contains four stereogenic centers, has been the starting point for an optimization…”
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The design and synthesis of thrombin inhibitors: analogues of MD805 containing non-polar surrogates for arginine at the P1 position by Baettig, Urs, Brown, Lyndon, Brundish, Derek, Dell, Colin, Furzer, Alex, Garman, Sheila, Janus, Diana, Kane, Peter D, Smith, Garrick, Walker, Clive V, Cockcroft, Xiaoling, Ambler, John, Mitchelson, Andrew, Talbot, Mark D, Tweed, Morris, Wills, Nicholas

“…A series of monocyclic and bicyclic amino acids have been synthesised and incorporated into thrombin inhibitors based on CGH728, an analogue of the Mitsubishi…”
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