Search Results - "Jantzen, H M"

Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins by Jantzen, Hans-Michael, Admon, Arie, Bell, Stephen P, Tjian, Robert

“…The eukaryotic upstream binding factor (UBF), recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through…”
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Cisplatin-DNA Adducts are Molecular Decoys for the Ribosomal RNA Transcription Factor hUBF (Human Upstream Binding Factor) by Treiber, Daniel K., Zhai, Xiaoquan, Jantzen, Hans-Michael, Essigmann, John M.

“…The toxicity of DNA-damaging agents is widely believed to result from the formation of lesions that block polymerases or disrupt the integrity of the genome. A…”
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Evidence for two distinct G-protein-coupled ADP receptors mediating platelet activation by Jantzen, H M, Gousset, L, Bhaskar, V, Vincent, D, Tai, A, Reynolds, E E, Conley, P B

“…The identity of the receptors mediating platelet activation by ADP remains elusive. To distinguish between platelet ADP receptor subtypes, the effects of…”
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Cooperativity of glucocorticoid response elements located far upstream of the tyrosine aminotransferase gene by Jantzen, H M, Strähle, U, Gloss, B, Stewart, F, Schmid, W, Boshart, M, Miksicek, R, Schütz, G

“…Two glucocorticoid response elements (GREs) located 2.5 kb upstream of the transcription initiation site of the tyrosine aminotransferase gene were identified…”
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Multiple domains of the RNA polymerase I activator hUBF interact with the TATA-binding protein complex hSL1 to mediate transcription by JANTZEN, H.-M, MING CHOW, A, KING, D. S, TJIAN, R

“…Recent evidence suggests that transcription initiation by all three eukaryotic RNA polymerases involves a complex of the TATA-binding protein (TBP) and…”
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Cisplatin−DNA Adducts Inhibit Ribosomal RNA Synthesis by Hijacking the Transcription Factor Human Upstream Binding Factor by Zhai, Xiaoquan, Beckmann, Holger, Jantzen, Hans-Michael, Essigmann, John M

“…Several eukaryotic cellular proteins recognize DNA modified by the anticancer drug cisplatin (cis-diamminedichloroplatinum(II) or cis-DDP); among these…”
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Assembly of alternative multiprotein complexes directs rRNA promoter selectivity by Bell, S P, Jantzen, H M, Tjian, R

“…How can trans-activators with the same DNA binding specificity direct different transcriptional programs? The rRNA transcriptional apparatus offers a useful…”
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Identification of the platelet ADP receptor targeted by antithrombotic drugs by Conley, Pamela B, Hollopeter, Gunther, Jantzen, Hans-Michael, Vincent, Diana, Li, Georgia, England, Laura, Ramakrishnan, Vanitha, Yang, Ruey-Bing, Nurden, Paquita, Nurden, Alan, Julius, David

“…Platelets have a crucial role in the maintenance of normal haemostasis, and perturbations of this system can lead to pathological thrombus formation and…”
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Functional Cooperativity between Transcription Factors UBF1 and SL1 Mediates Human Ribosomal RNA Synthesis by Bell, Stephen P., Learned, R. Marc, Jantzen, Hans-Michael, Tjian, Robert

“…The human ribosomal RNA promoter contains two distinct control elements (UCE and core) both of which are recognized by the sequence-specific DNA binding…”
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Impaired activation of murine platelets lacking G alpha(i2) by Jantzen, H M, Milstone, D S, Gousset, L, Conley, P B, Mortensen, R M

“…The intracellular signaling pathways by which G protein-coupled receptors on the platelet surface initiate aggregation, a critical process for hemostasis and…”
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Diadenosine 5',5'''-P1,P4-tetraphosphate, a ligand of the 57-kilodalton subunit of DNA polymerase alpha by Grummt, F, Waltl, G, Jantzen, H M, Hamprecht, K, Huebscher, U, Kuenzle, C C

“…By equilibrium dialysis a disadenosine 5',5'''-P1,P2-tetraphosphate (Ap4A) binding activity is shown to be present in mammalian cells. The Ap4A binding…”
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New cosmid vectors developed for eukaryotic DNA cloning by Brady, G, Jantzen, H M, Bernard, H U, Brown, R, Schütz, G, Hashimoto-Gotoh, T

“…A series of ColE1 and pSC101 cosmid vectors have been constructed suitable for cloning large stretches of DNA. All contain a single BamHI site allowing cloning…”
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Cyclic nucleotide-dependent protein kinases from cilia of Paramecium tetraurelia: Partial purification and characterization by Schultz, Joachim E., Jantzen, H.-Michael

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Impaired activation of murine platelets lacking G sub( alpha i2) by Jantzen, H-M, Milstone, D S, Gousset, L, Conley, P B, Mortensen, R M

“…The intracellular signaling pathways by which G protein-coupled receptors on the platelet surface initiate aggregation, a critical process for hemostasis and…”
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Novel tricyclic benzothiazolo[2,3-c]thiadiazine antagonists of the platelet ADP receptor (P2Y12) by SCARBOROUGH, Robert M, LAIBELMAN, Alan M, CLIZBE, Lane A, FRETTO, Larry J, CONLEY, Pamela B, REYNOLDS, Elwood E, SEDLOCK, David M, JANTZEN, Hans-Michael

“…Novel non-nucleoside tricyclic platelet ADP receptor (P2Y(12)) antagonists have been discovered that bind reversibly and with high affinity to the platelet…”
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Functional cooperativity between transcription factors UBFI and SL1 mediates human ribosomal RNA synthesis by BELL, S. P, LEARNED, R. M, JANTZEN, H.-M, TJIAN, R

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