Search Results - "Jansson, J."

Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance by Matthews, V. B, Allen, T. L, Risis, S, Chan, M. H. S, Henstridge, D. C, Watson, N, Zaffino, L. A, Babb, J. R, Boon, J, Meikle, P. J, Jowett, J. B, Watt, M. J, Jansson, J.-O, Bruce, C. R, Febbraio, M. A

“…Aims/hypothesis The role of IL-6 in the development of obesity and hepatic insulin resistance is unclear and still the subject of controversy. We aimed to…”
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Molecular pharmacology of ABCG2 and its role in chemoresistance by Stacy, Alexandra E, Jansson, Patric J, Richardson, Des R

“…The ATP-binding cassette, subfamily G, isoform 2 protein (ABCG2) is an important member of the ABC transporter superfamily, which has been suggested to be…”
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Large improvements in major cardiovascular risk factors in the population of northern Sweden: the MONICA study 1986–2009 by Eriksson, M., Holmgren, L., Janlert, U., Jansson, J.‐H., Lundblad, D., Stegmayr, B., Söderberg, S., Eliasson, M.

“…  Eriksson M, Holmgren L, Janlert U, Jansson J‐H, Lundblad D, Stegmayr B, Söderberg S, Eliasson M (Department of Public Health and Clinical Medicine, Umeå…”
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Failed spinal anaesthesia: mechanisms, management, and prevention by Fettes, P.D.W., Jansson, J.-R., Wildsmith, J.A.W.

“…Although spinal (subarachnoid or intrathecal) anaesthesia is generally regarded as one of the most reliable types of regional block methods, the possibility of…”
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Relative risk of cardiovascular disease among people living with HIV: a systematic review and meta‐analysis by Islam, FM, Wu, J, Jansson, J, Wilson, DP

“…Objectives The aim of this study was to estimate the relative risk of cardiovascular disease (CVD) among people living with HIV (PLHIV) compared with the…”
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Inter-relation between Interleukin (IL)-1, IL-6 and Body Fat Regulating Circuits of the Hypothalamic Arcuate Nucleus by Schéle, E., Benrick, A., Grahnemo, L., Egecioglu, E., Anesten, F., Pálsdóttir, V., Jansson, J.-O.

“…Interleukin (IL)‐1 and IL‐6 are immune modulating cytokines that also affect metabolic function because both IL‐1 receptor I deficient (IL‐1RI−/−) and IL‐6…”
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Acceptability of electric vehicle aimed measures: Effects of norm activation, perceived justice and effectiveness by Nordlund, A., Jansson, J., Westin, K.

“…•Norm activation is a part of the process of accepting EV focused policies.•Environmentally focused attitudinal factors are important for norm…”
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Structure–Activity Relationships of Di-2-pyridylketone, 2‑Benzoylpyridine, and 2‑Acetylpyridine Thiosemicarbazones for Overcoming Pgp-Mediated Drug Resistance by Stacy, Alexandra E, Palanimuthu, Duraippandi, Bernhardt, Paul V, Kalinowski, Danuta S, Jansson, Patric J, Richardson, Des R

“…Multidrug resistance (MDR) mediated by P-glycoprotein (Pgp) represents a significant impediment to successful cancer treatment. The compound,…”
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Glucose modulation induces reactive oxygen species and increases P‐glycoprotein‐mediated multidrug resistance to chemotherapeutics by Seebacher, N A, Richardson, D R, Jansson, P J

“…Background and Purpose Cancer cells develop resistance to stress induced by chemotherapy. In tumours, a considerable glucose gradient exists, resulting in…”
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Breaking the cycle: Targeting of NDRG1 to inhibit bi‐directional oncogenic cross‐talk between pancreatic cancer and stroma by Geleta, Bekesho, Park, Kyung Chan, Jansson, Patric J., Sahni, Sumit, Maleki, Sanaz, Xu, Zhihong, Murakami, Takashi, Pajic, Marina, Apte, Minoti V., Richardson, Des R., Kovacevic, Zaklina

“…Pancreatic cancer (PaCa) is characterized by dense stroma that hinders treatment efficacy, with pancreatic stellate cells (PSCs) being a major contributor to…”
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The Genomes OnLine Database (GOLD) v.4: status of genomic and metagenomic projects and their associated metadata by Pagani, Ioanna, Liolios, Konstantinos, Jansson, Jakob, Chen, I-Min A., Smirnova, Tatyana, Nosrat, Bahador, Markowitz, Victor M., Kyrpides, Nikos C.

“…The Genomes OnLine Database (GOLD, http://www.genomesonline.org/) is a comprehensive resource for centralized monitoring of genome and metagenome projects…”
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The renaissance of polypharmacology in the development of anti-cancer therapeutics: Inhibition of the “Triad of Death” in cancer by Di-2-pyridylketone thiosemicarbazones by Jansson, Patric J., Kalinowski, Danuta S., Lane, Darius J.R., Kovacevic, Zaklina, Seebacher, Nicole A., Fouani, Leyla, Sahni, Sumit, Merlot, Angelica M., Richardson, Des R.

“…[Display omitted] Cancer is a disease that is a “moving target”, since as the condition progresses, the molecular targets change and evolve. Moreover, due to…”
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Glucose Modulation Induces Lysosome Formation and Increases Lysosomotropic Drug Sequestration via the P-Glycoprotein Drug Transporter by Seebacher, Nicole A., Lane, Darius J.R., Jansson, Patric J., Richardson, Des R.

“…Pgp is functional on the plasma membrane and lysosomal membrane. Lysosomal-Pgp can pump substrates into the organelle, thereby trapping certain…”
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Fibroblast Biomarkers of Sporadic Parkinson’s Disease and LRRK2 Kinase Inhibition by Smith, G. A., Jansson, J., Rocha, E. M., Osborn, T., Hallett, P. J., Isacson, O.

“…It has been uncertain whether specific disease-relevant biomarker phenotypes can be found using sporadic Parkinson’s disease (PD) patient-derived samples, as…”
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Snus (Swedish smokeless tobacco) use and risk of stroke: pooled analyses of incidence and survival by Hansson, J., Galanti, M. R., Hergens, M.‐P., Fredlund, P., Ahlbom, A., Alfredsson, L., Bellocco, R., Engström, G., Eriksson, M., Hallqvist, J., Hedblad, B., Jansson, J.‐H., Pedersen, N. L., Trolle Lagerros, Y., Östergren, P.‐O., Magnusson, C.

“…Background Snus is a moist smokeless tobacco product with high nicotine content. Its use has a short‐term effect on the cardiovascular system, but the…”
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Molecular functions of the iron-regulated metastasis suppressor, NDRG1, and its potential as a molecular target for cancer therapy by Fang, Bernard A., Kovačević, Žaklina, Park, Kyung Chan, Kalinowski, Danuta S., Jansson, Patric J., Lane, Darius J.R., Sahni, Sumit, Richardson, Des R.

“…N-myc down-regulated gene 1 (NDRG1) is a known metastasis suppressor in multiple cancers, being also involved in embryogenesis and development, cell growth and…”
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A unified initiative to harness Earth's microbiomes by Alivisatos, A. P., Blaser, M. J., Brodie, E. L., Chun, M., Dangl, J. L., Donohue, T. J., Dorrestein, P. C., Gilbert, J. A., Green, J. L., Jansson, J. K., Knight, R., Maxon, M. E., McFall-Ngai, M. J., Miller, J. F., Pollard, K. S., Ruby, E. G., Taha, S. A.

“…Transition from description to causality and engineering Despite their centrality to life on Earth, we know little about how microbes ( 1 ) interact with each…”
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Innovative thiosemicarbazones that induce multi-modal mechanisms to down-regulate estrogen-, progesterone-, androgen- and prolactin-receptors in breast cancer by Shehadeh-Tout, Faten, Milioli, Heloisa H., Roslan, Suraya, Jansson, Patric J., Dharmasivam, Mahendiran, Graham, Dinny, Anderson, Robin, Wijesinghe, Tharushi, Azad, Mahan Gholam, Richardson, Des R., Kovacevic, Zaklina

“…The estrogen receptor-α (ER-α) is a key driver of breast cancer (BC) and the ER-antagonist, tamoxifen, is a central pillar of BC treatment. However, cross-talk…”
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A CMOS time-to-digital converter with better than 10 ps single-shot precision by Jansson, J.-P., Mantyniemi, A., Kostamovaara, J.

“…A high-precision CMOS time-to-digital converter IC has been designed. Time interval measurement is based on a counter and two-level interpolation realized with…”
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Thiosemicarbazones suppress expression of the c-Met oncogene by mechanisms involving lysosomal degradation and intracellular shedding by Park, Kyung Chan, Geleta, Bekesho, Leck, Lionel Yi Wen, Paluncic, Jasmina, Chiang, Shannon, Jansson, Patric J., Kovacevic, Zaklina, Richardson, Des R.

“…Considering the role of proto-oncogene c-Met (c-Met) in oncogenesis, we examined the effects of the metastasis suppressor, N-myc downstream-regulated gene-1…”
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