Search Results - "Janssens, H"

2016 updated EULAR evidence-based recommendations for the management of gout by Richette, P, Doherty, M, Pascual, E, Barskova, V, Becce, F, Castañeda-Sanabria, J, Coyfish, M, Guillo, S, Jansen, T L, Janssens, H, Lioté, F, Mallen, C, Nuki, G, Perez-Ruiz, F, Pimentao, J, Punzi, L, Pywell, T, So, A, Tausche, A K, Uhlig, T, Zavada, J, Zhang, W, Tubach, F, Bardin, T

“…New drugs and new evidence concerning the use of established treatments have become available since the publication of the first European League Against…”
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Pioneer Factor-Nucleosome Binding Events during Differentiation Are Motif Encoded by Meers, Michael P., Janssens, Derek H., Henikoff, Steven

“…Although the in vitro structural and in vivo spatial characteristics of transcription factor (TF) binding are well defined, TF interactions with chromatin and…”
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What the pulmonary specialist should know about the new inhalation therapies by LAUBE, B. L, JANSSENS, H. M, CHRYSTYN, H, DE JONGH, F. H. C, DEVADASON, S. G, DHAND, R, DIOT, P, EVERARD, M. L, HORVATH, I, NAVALESI, P, VOSHAAR, T

“…A collaboration of multidisciplinary experts on the delivery of pharmaceutical aerosols was facilitated by the European Respiratory Society (ERS) and the…”
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Multifactorial profiling of epigenetic landscapes at single-cell resolution using MulTI-Tag by Meers, Michael P., Llagas, Geneva, Janssens, Derek H., Codomo, Christine A., Henikoff, Steven

“…Chromatin profiling at locus resolution uncovers gene regulatory features that define cell types and developmental trajectories, but it remains challenging to…”
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CUT&Tag2for1: a modified method for simultaneous profiling of the accessible and silenced regulome in single cells by Janssens, Derek H, Otto, Dominik J, Meers, Michael P, Setty, Manu, Ahmad, Kami, Henikoff, Steven

“…Cleavage Under Targets and Tagmentation (CUT&Tag) is an antibody-directed transposase tethering strategy for in situ chromatin profiling in small samples and…”
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A modular CRISPR screen identifies individual and combination pathways contributing to HIV-1 latency by Hsieh, Emily, Janssens, Derek H, Paddison, Patrick J, Browne, Edward P, Henikoff, Steve, OhAinle, Molly, Emerman, Michael

“…Transcriptional silencing of latent HIV-1 proviruses entails complex and overlapping mechanisms that pose a major barrier to in vivo elimination of HIV-1. We…”
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MLL oncoprotein levels influence leukemia lineage identities by Janssens, Derek H., Duran, Melodie, Otto, Dominik J., Wu, Weifang, Xu, Yiling, Kirkey, Danielle, Mullighan, Charles G., Yi, Joanna S., Meshinchi, Soheil, Sarthy, Jay F., Ahmad, Kami, Henikoff, Steven

“…Chromosomal translocations involving the mixed-lineage leukemia (MLL ) locus generate potent oncogenic fusion proteins (oncoproteins) that disrupt regulation…”
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Histone marks identify novel transcription factors that parse CAR-T subset-of-origin, clinical potential and expansion by Fiorenza, S., Zheng, Y., Purushe, J., Bock, T. J., Sarthy, J., Janssens, D. H., Sheih, A. S., Kimble, E. L., Kirchmeier, D., Phi, T. D., Gauthier, J., Hirayama, A. V., Riddell, S. R., Wu, Q., Gottardo, R., Maloney, D. G., Yang, J. Y. H., Henikoff, S., Turtle, C. J.

“…Chimeric antigen receptor-modified T cell (CAR-T) immunotherapy has revolutionised blood cancer treatment. Parsing the genetic underpinnings of T cell quality…”
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Long-Term Green Tea Supplementation Does Not Change the Human Gut Microbiota by Janssens, Pilou L H R, Penders, John, Hursel, Rick, Budding, Andries E, Savelkoul, Paul H M, Westerterp-Plantenga, Margriet S

“…Green tea catechins may play a role in body weight regulation through interactions with the gut microbiota. We examined whether green tea supplementation for…”
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Histone deposition pathways determine the chromatin landscapes of H3.1 and H3.3 K27M oncohistones by Sarthy, Jay F, Meers, Michael P, Janssens, Derek H, Henikoff, Jorja G, Feldman, Heather, Paddison, Patrick J, Lockwood, Christina M, Vitanza, Nicholas A, Olson, James M, Ahmad, Kami, Henikoff, Steven

“…Lysine 27-to-methionine (K27M) mutations in the H3.1 or H3.3 histone genes are characteristic of pediatric diffuse midline gliomas (DMGs). These oncohistone…”
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Hair cortisol in relation to job stress and depressive symptoms by Janssens, H, Clays, E, Fiers, T, Verstraete, A G, de Bacquer, D, Braeckman, L

“…Measurement of hair cortisol concentration (HCC) may be used as a biomarker for chronic stress. However, the association between stress and HCC has rarely been…”
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Earmuff restricts progenitor cell potential by attenuating the competence to respond to self-renewal factors by Janssens, Derek H, Komori, Hideyuki, Grbac, Daniel, Chen, Keng, Koe, Chwee Tat, Wang, Hongyan, Lee, Cheng-Yu

“…Despite expressing stem cell self-renewal factors, intermediate progenitor cells possess restricted developmental potential, which allows them to give rise…”
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An Hdac1/Rpd3-Poised Circuit Balances Continual Self-Renewal and Rapid Restriction of Developmental Potential during Asymmetric Stem Cell Division by Janssens, Derek H., Hamm, Danielle C., Anhezini, Lucas, Xiao, Qi, Siller, Karsten H., Siegrist, Sarah E., Harrison, Melissa M., Lee, Cheng-Yu

“…How the developmental potential of differentiating stem cell progeny becomes rapidly and stably restricted following asymmetric stem cell division is unclear…”
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Acute effects of capsaicin on energy expenditure and fat oxidation in negative energy balance by Janssens, Pilou L H R, Hursel, Rick, Martens, Eveline A P, Westerterp-Plantenga, Margriet S

“…Addition of capsaicin (CAPS) to the diet has been shown to increase energy expenditure; therefore capsaicin is an interesting target for anti-obesity therapy…”
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Automated in situ chromatin profiling efficiently resolves cell types and gene regulatory programs by Janssens, Derek H, Wu, Steven J, Sarthy, Jay F, Meers, Michael P, Myers, Carrie H, Olson, James M, Ahmad, Kami, Henikoff, Steven

“…Our understanding of eukaryotic gene regulation is limited by the complexity of protein-DNA interactions that comprise the chromatin landscape and by…”
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Subtherapeutic triazole concentrations as result of a drug-drug interaction with lumacaftor/ivacaftor by Smeets, T.J.L., van der Sijs, H., Janssens, H.M., Ruijgrok, E.J., de Winter, B.C.M.

“…•Strong induction of CYP3A4 and UGT by lumacaftor/ivacaftor (Orkambi®, LUM/IVA) can reduce the plasma concentration of triazole antifungals.•Concomitant use of…”
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Sequential activation of transcriptional repressors promotes progenitor commitment by silencing stem cell identity genes by Rives-Quinto, Noemi, Komori, Hideyuki, Ostgaard, Cyrina M, Janssens, Derek H, Kondo, Shu, Dai, Qi, Moore, Adrian W, Lee, Cheng-Yu

“…Stem cells that indirectly generate differentiated cells through intermediate progenitors drives vertebrate brain evolution. Due to a lack of lineage…”
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Global and context-specific transcriptional consequences of oncogenic Fbw7 mutations by Thirimanne, H Nayanga, Wu, Feinan, Janssens, Derek H, Swanger, Jherek, Diab, Ahmed, Feldman, Heather M, Amezquita, Robert A, Gottardo, Raphael, Paddison, Patrick J, Henikoff, Steven, Clurman, Bruce E

“…The Fbw7 ubiquitin ligase targets many proteins for proteasomal degradation, which include oncogenic transcription factors (TFs) (e.g., c-Myc, c-Jun, and…”
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Real life data on incidence and risk factors of severe asthma exacerbations in children in primary care by Engelkes, M, Janssens, H.M, de Ridder, M.A.J, Sturkenboom, M.C.J.M, de Jongste, J.C, Verhamme, K.M.C

“…Abstract Real-life data on the incidence rates (IR) and risk factors of severe asthma exacerbations in children are sparse. We aimed to assess IR and risk…”
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The relation between psychosocial risk factors and cause-specific long-term sickness absence by Janssens, Heidi, Clays, Els, De Clercq, Bart, Casini, Annalisa, De Bacquer, Dirk, Kittel, France, Braeckman, Lutgart

“…The aim was to study the impact of psychosocial risk factors on long-term sickness absence due to mental health problems (LSA-MH) or musculoskeletal disorders…”
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