Search Results - "Janssen, Rob G.J.H"

Immunoregulatory gene polymorphisms are associated with ANCA-related vasculitis by Slot, Marjan C, Sokolowska, Milena G, Savelkouls, Kim G, Janssen, Rob G.J.H, Damoiseaux, Jan G.M.C, Cohen Tervaert, Jan Willem

“…Abstract T cell activation is regulated by inhibitory molecules such as PD-1 and CTLA-4, whose expression may be affected by gene polymorphisms. Increased T…”
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Effectiveness of statins in the reduction of the risk of myocardial infarction is modified by the GNB3 C825T variant by Peters, Bas J.M, Maitland-van der Zee, Anke-Hilse, Stricker, Bruno H.Ch, van Wieren-de Wijer, Diane B.M.A, de Boer, Anthonius, Kroon, Abraham A, de Leeuw, Peter W, Schiffers, Paul, Janssen, Rob G.J.H, van Duijn, Cornelia M, Klungel, Olaf H

“…INTRODUCTIONThe GNB3 C825T polymorphism has been shown to affect lipid parameters, atherosclerosis progression, and incidence of myocardial infarction (MI)…”
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Identification of TNFRSF1B as a novel modifier gene in familial combined hyperlipidemia by GEURTS, J. M. W, JANSSEN, R. G. J. H, VAN GREEVENBROEK, M. M. J, VAN DER KALLEN, C. J. H, CANTOR, R. M, BU, X.-D, AOUIZERAT, B. E, ALLAYEE, H, ROTTER, J. I, DE BRUIN, T. W. A

“…Familial combined hyperlipidemia (FCHL) is the most commonly inherited hyperlipidemia in man, with a frequency of +/-1% in the general population and…”
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Association between the α-adducin Gly460Trp polymorphism and systolic blood pressure in familial combined hyperlipidemia by Beeks, Esther, Janssen, Rob G.J.H, Kroon, Abraham A, Keulen, Eric T.P, Geurts, Jan M.W, de Leeuw, Peter W, de Bruin, Tjerk W.A

“…In a genome scan for familial combined hyperlipidemia (FCHL), a locus contributing to systolic blood pressure (SBP) has been identified on chromosome 4,…”
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A Functional Polymorphism of the μ-Opioid Receptor Gene (OPRM1) Influences Cue-Induced Craving for Alcohol in Male Heavy Drinkers by Van Den Wildenberg, Esther, Wiers, Reinout W., Dessers, Joelle, Janssen, Rob G. J. H., Lambrichs, Ellen H., Smeets, Hubert J. M., Van Breukelen, Gerard J. P.

“…Background: The μ‐opioid receptor gene (OPRM1) codes for the μ‐opioid receptor, which binds β‐endorphin. The A118G polymorphism in this gene affects…”
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Interaction between the Gly460Trp alpha-adducin gene variant and diuretics on the risk of myocardial infarction by van Wieren-de Wijer, Diane B M A, Maitland-van der Zee, Anke-Hilse, de Boer, Anthonius, Kroon, Abraham A, de Leeuw, Peter W, Schiffers, Paul, Janssen, Rob G J H, Psaty, Bruce M, van Duijn, Cornelia M, Stricker, Bruno H Ch, Klungel, Olaf H

“…The Gly460Trp variant of the alpha-adducin gene has been associated with the salt-sensitive and diuretic responsive form of hypertension. The aim of the study…”
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The influence of 5-HTTLPR and STin2 polymorphisms in the serotonin transporter gene on treatment effect of selective serotonin reuptake inhibitors in depressive patients by Smits, Kim M, Smits, Luc J M, Peeters, Frenk P M L, Schouten, Jan S A G, Janssen, Rob G J H, Smeets, Hubert J M, van Os, Jim, Prins, Martin H

“…Serotonin transporter gene (SLC6A4) variations have been proposed as an explanation for interindividual differences in selective serotonin reuptake inhibitors…”
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Polymorphisms of the dopamine D4 receptor gene (DRD4 VNTR) and cannabinoid CB1 receptor gene (CNR1) are not strongly related to cue-reactivity after alcohol exposure by van den Wildenberg, Esther, Janssen, Rob G J H, Hutchison, Kent E, van Breukelen, Gerard J P, Wiers, Reinout W

“…Polymorphisms in the D4 dopamine receptor gene (DRD4) and the CB1 cannabinoid receptor gene (CNR1) have been associated with a differential response to alcohol…”
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Genetic variation in the renin—angiotensin system, use of renin—angiotensin system inhibitors and the risk of myocardial infarction by Maitland-van der Zee, Anke-Hilse, van Wieren-de Wijer, Diane BMA, de Boer, Anthonius, Kroon, Abraham A, de Leeuw, Peter W, Schiffers, Paul, Janssen, Rob GJH, Psaty, Bruce M, van Duijn, Cornelia M, Stricker, Bruno HCh, Klungel, Olaf H

“…Introduction. This study investigated whether variation in the genes encoding for ACE, AGT and AGTR1 modifies the risk of myocardial infarction (MI) related to…”
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Reasons for non-response in observational pharmacogenetic research by van Wieren-de Wijer, Diane B.M.A., Maitland-van der Zee, Anke-Hilse, de Boer, Anthonius, Kroon, Abraham A., de Leeuw, Peter W., Schiffers, Paul, Janssen, Rob G.J.H., Psaty, Bruce M., van Duijn, Cornelia M., Stricker, Bruno H. Ch, Klungel, Olaf H.

“…Purpose In epidemiological studies, non‐response may introduce bias and limit generalizability. In genetic pharmacoepidemiological research, collection of DNA…”
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Simultaneous genotyping of nine polymorphisms in xenobiotic-metabolizing enzymes by multiplex PCR amplification and single base extension by KNAAPEN, Ad M, KETELSLEGERS, Hans B, GOTTSCHALK, Ralph W. H, JANSSEN, Rob G. J. H, PAULUSSEN, Aimee D. C, SWEETS, Hubert J. M, GODSCHALK, Roger W. L, VAN SCHOOTEN, Frederik J, KLEINJANS, Jos C. S, VAN DELFT, Joost H. M

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Influence of the endothelial nitric oxide synthase gene on conventional and ambulatory blood pressure: sib-pair analysis and haplotype study by Persu, Alexandre, Vinck, Wouter J, Khattabi, Ouarda El, Janssen, Rob GJH, Paulussen, Aimée DC, Devuyst, Olivier, Vlietinck, Robert, Fagard, Robert H

“…BACKGROUNDNitric oxide is involved in the regulation of vascular basal tone and blood pressure. Polymorphisms of NOS3, the gene that codes for endothelial…”
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Anthropometry, Carbohydrate and Lipid Metabolism in the East Flanders Prospective Twin Survey: Linkage of Candidate Genes Using Two Sib-Pair Based Variance Components Analyses by Souren, Nicole Y., Zeegers, Maurice P., Janssen, Rob G. J. H., Steyls, Anja, Gielen, Marij, Loos, Ruth J. F., Beunen, Gaston, Fagard, Robert, Stassen, Alphons P. M., Aerssens, Jeroen, Derom, Catherine, Vlietinck, Robert, Paulussen, Aimee D. C.

“…Insulin resistance and obesity are underlying causes of type 2 diabetes and therefore much interest is focused on the potential genes involved. A series of…”
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Soluble receptors for tumor necrosis factor-α (TNF-R p55 and TNF-R p75) in familial combined hyperlipidemia by van Greevenbroek, Marleen M.J., van der Kallen, Carla J.H., Geurts, Jan M.W., Janssen, Rob G.J.H., Buurman, Wim A., de Bruin, Tjerk W.A.

“…We investigated the potential role of the 75 kD receptor for tumor necrosis factor-α (TNF-α) ( TNFRSF1B, located on chromosome 1 band p36.2) as a modifier gene…”
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