Search Results - "Janssen, Paul J."

The complete genome sequence of Cupriavidus metallidurans strain CH34, a master survivalist in harsh and anthropogenic environments by Janssen, Paul J, Van Houdt, Rob, Moors, Hugo, Monsieurs, Pieter, Morin, Nicolas, Michaux, Arlette, Benotmane, Mohammed A, Leys, Natalie, Vallaeys, Tatiana, Lapidus, Alla, Monchy, Sébastien, Médigue, Claudine, Taghavi, Safiyh, McCorkle, Sean, Dunn, John, van der Lelie, Daniël, Mergeay, Max

“…Many bacteria in the environment have adapted to the presence of toxic heavy metals. Over the last 30 years, this heavy metal tolerance was the subject of…”
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CGG toolkit: Software components for computational genomics by Vasileiou, Dimitrios, Karapiperis, Christos, Baltsavia, Ismini, Chasapi, Anastasia, Ahrén, Dag, Janssen, Paul J, Iliopoulos, Ioannis, Promponas, Vasilis J, Enright, Anton J, Ouzounis, Christos A

“…Public-domain availability for bioinformatics software resources is a key requirement that ensures long-term permanence and methodological reproducibility for…”
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Electric Polarization-Dependent Absorption and Photocurrent Generation in Limnospira indica Immobilized on Boron-Doped Diamond by Ryzhkov, Nikolay, Colson, Nora, Ahmed, Essraa, Pobedinskas, Paulius, Haenen, Ken, Braun, Artur, Janssen, Paul J.

“…We present the change of light absorption of cyanobacteria in response to externally applied electrical polarization. Specifically, we studied the relation…”
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Arsenic: bioaccessibility from seaweed and rice, dietary exposure calculations and risk assessment by Brandon, Esther F.A, Janssen, Paul J.C.M, de Wit-Bos, Lianne

“…Arsenic is a metalloid that occurs in food and the environment in different chemical forms. Inorganic arsenic is classified as a class I carcinogen. The…”
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In Search of a Novel Anti-HIV Drug:  Multidisciplinary Coordination in the Discovery of 4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, Rilpivirine) by Janssen, Paul A. J, Lewi, Paul J, Arnold, Eddy, Daeyaert, Frits, de Jonge, Marc, Heeres, Jan, Koymans, Luc, Vinkers, Maarten, Guillemont, Jérôme, Pasquier, Elisabeth, Kukla, Mike, Ludovici, Don, Andries, Koen, de Béthune, Marie-Pierre, Pauwels, Rudi, Das, Kalyan, Clark, Art D, Frenkel, Yulia Volovik, Hughes, Stephen H, Medaer, Bart, De Knaep, Fons, Bohets, Hilde, De Clerck, Fred, Lampo, Ann, Williams, Peter, Stoffels, Paul

“…Ideally, an anti-HIV drug should (1) be highly active against wild-type and mutant HIV without allowing breakthrough; (2) have high oral bioavailability and…”
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Pediatric Microdose Study of [14C]Paracetamol to Study Drug Metabolism Using Accelerated Mass Spectrometry: Proof of Concept by Mooij, Miriam G., van Duijn, Esther, Knibbe, Catherijne A. J., Windhorst, Albert D., Hendrikse, N. Harry, Vaes, Wouter H. J., Spaans, Edwin, Fabriek, Babs O., Sandman, Hugo, Grossouw, Dimitri, Hanff, Lidwien M., Janssen, Paul J. J. M., Koch, Birgit C. P., Tibboel, Dick, de Wildt, Saskia N.

“…Background Pediatric drug development is hampered by practical, ethical, and scientific challenges. Microdosing is a promising new method to obtain…”
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Concentration and pH Dependent Aggregation of Hydrophobic Drug Molecules and Relevance to Oral Bioavailability by Frenkel, Yulia Volovik, Clark, Arthur D, Das, Kalyan, Wang, Yuh-Hwa, Lewi, Paul J, Janssen, Paul A. J, Arnold, Eddy

“…We have examined selected physicochemical properties of compounds from the diaryltriazine/diarylpyrimidine (DATA/DAPY) classes of non-nucleoside reverse…”
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SYNOPSIS:  SYNthesize and OPtimize System in Silico by Vinkers, H. Maarten, de Jonge, Marc R, Daeyaert, Frederik F. D, Heeres, Jan, Koymans, Lucien M. H, van Lenthe, Joop H, Lewi, Paul J, Timmerman, Henk, Van Aken, Koen, Janssen, Paul A. J

“…We present a de novo design program called SYNOPSIS, that includes a synthesis route for each generated molecule. SYNOPSIS designs novel molecules by starting…”
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Photosynthesis at the forefront of a sustainable life by Janssen, Paul J D, Lambreva, Maya D, Plumeré, Nicolas, Bartolucci, Cecilia, Antonacci, Amina, Buonasera, Katia, Frese, Raoul N, Scognamiglio, Viviana, Rea, Giuseppina

“…The development of a sustainable bio-based economy has drawn much attention in recent years, and research to find smart solutions to the many inherent…”
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Fluorescence and electron transfer of Limnospira indica functionalized biophotoelectrodes by Ryzhkov, Nikolay, Colson, Nora, Ahmed, Essraa, Pobedinskas, Paulius, Haenen, Ken, Janssen, Paul J., Braun, Artur

“…Cyanobacteria play a crucial role in global carbon and nitrogen cycles through photosynthesis, making them valuable subjects for understanding the factors…”
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Efficacy of opioid rotation to continuous parenteral hydromorphone in advanced cancer patients failing on other opioids by Oldenmenger, Wendy H., Lieverse, Paul J, Janssen, Paul J. J. M., Taal, Walter, van der Rijt, Carin C. D., Jager, Agnes

“…Purpose The effectiveness of an opioid rotation to parenteral hydromorphone in advanced cancer patients has never been investigated. Therefore, the purpose of…”
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Heavy metal resistance in Cupriavidus metallidurans CH34 is governed by an intricate transcriptional network by Monsieurs, Pieter, Moors, Hugo, Van Houdt, Rob, Janssen, Paul J., Janssen, Ann, Coninx, Ilse, Mergeay, Max, Leys, Natalie

“…The soil bacterium Cupriavidus metallidurans CH34 contains a high number of heavy metal resistance genes making it an interesting model organism to study…”
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Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective against Wild-Type and Drug-Resistant HIV-1 Variants by Das, Kalyan, Clark, Arthur D, Lewi, Paul J, Heeres, Jan, de Jonge, Marc R, Koymans, Lucien M. H, Vinkers, H. Maarten, Daeyaert, Frederik, Ludovici, Donald W, Kukla, Michael J, De Corte, Bart, Kavash, Robert W, Ho, Chih Y, Ye, Hong, Lichtenstein, Mark. A, Andries, Koen, Pauwels, Rudi, de Béthune, Marie-Pierre, Boyer, Paul L, Clark, Patrick, Hughes, Stephen H, Janssen, Paul A. J, Arnold, Eddy

“…Anti-AIDS drug candidate and non-nucleoside reverse transcriptase inhibitor (NNRTI) TMC125-R165335 (etravirine) caused an initial drop in viral load similar to…”
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Clinical efficacy of lead revisions during the test phase in sacral neuromodulation for fecal incontinence by Janssen, Paul T. J., Melenhorst, Jarno, Stassen, Laurents P. S., Bouvy, Nicole D., Breukink, Stephanie O.

“…Background Success rates of up to 80% have been reported for the SNM screening period in the treatment of fecal incontinence (FI). Some patients who have an…”
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Helical and linear morphotypes of Arthrospira sp. PCC 8005 display genomic differences and respond differently to 60Co gamma irradiation by Yadav, Anu, Monsieurs, Pieter, Misztak, Agnieszka, Waleron, Krzysztof, Leys, Natalie, Cuypers, Ann, Janssen, Paul J.

“…Arthrospira are multicellular cyanobacteria that typically reside in alkaline lakes of (sub)tropical regions and are mass cultivated around the globe in a…”
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Assessment of health risks due to arsenic from iron ore lumps in a beach setting by Swartjes, Frank A., Janssen, Paul J.C.M.

“…In 2011, an artificial hook-shaped peninsula of 128ha beach area was created along the Dutch coast, containing thousands of iron ore lumps, which include…”
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Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives by Pauwels, Rudi, Andries, Koen, Desmyter, Jan, Schols, Dominique, Kukla, Michael J, Breslin, Henry J, Raeymaeckers, Alfons, Gelder, Jozef Van, Woestenborghs, Robert, Heykants, Jozef, Schellekens, Karel, Janssen, Marcel A. C, Clercq, Erik De, Janssen, Paul A. J

“…In the search for compounds active against human immunodeficiency virus (HIV), we have found that members of a novel series of…”
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Unintentional Genomic Changes Endow Cupriavidus metallidurans with an Augmented Heavy-Metal Resistance by Millacura, Felipe A, Janssen, Paul J, Monsieurs, Pieter, Janssen, Ann, Provoost, Ann, Van Houdt, Rob, Rojas, Luis A

“…For the past three decades, has been one of the major model organisms for bacterial tolerance to heavy metals. Its type strain CH34 contains at least 24 gene…”
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Synthesis of Novel Diarylpyrimidine Analogues and Their Antiviral Activity against Human Immunodeficiency Virus Type 1 by Guillemont, Jerome, Pasquier, Elisabeth, Palandjian, Patrice, Vernier, Daniel, Gaurrand, Sandrine, Lewi, Paul J, Heeres, Jan, de Jonge, Marc R, Koymans, Lucien M. H, Daeyaert, Frits F. D, Vinkers, Maarten H, Arnold, Eddy, Das, Kalyan, Pauwels, Rudi, Andries, Koen, de Béthune, Marie-Pierre, Bettens, Eva, Hertogs, Kurt, Wigerinck, Piet, Timmerman, Philip, Janssen, Paul A. J

“…This paper reports the synthesis and the antiviral properties of new diarylpyrimidine (DAPY) compounds as nonnucleoside reverse transcriptase inhibitors…”
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Design, Synthesis, and SAR of a Novel Pyrazinone Series with Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitory Activity by Heeres, Jan, de Jonge, Marc R, Koymans, Lucien M. H, Daeyaert, Frits F. D, Vinkers, Maarten, Van Aken, Koen J. A, Arnold, Eddy, Das, Kalyan, Kilonda, Amuri, Hoornaert, Georges J, Compernolle, Frans, Cegla, Marek, Azzam, Rasha A, Andries, Koen, de Béthune, Marie-Pierre, Azijn, Hilde, Pauwels, Rudi, Lewi, Paul J, Janssen, Paul A. J

“…A series of novel pyrazinones designed as non-nucleoside reverse transcriptase inhibitors (NNRTIs) was synthesized and their anti-HIV structure−activity…”
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