Search Results - "Janssen, Luke"

Calcium Homeostasis and Ionic Mechanisms in Pulmonary Fibroblasts by Janssen, Luke J, Mukherjee, Subhendu, Ask, Kjetil

“…Fibroblasts are key cellular mediators of many chronic interstitial lung diseases, including idiopathic pulmonary fibrosis, scleroderma, sarcoidosis,…”
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TRPV4 Stimulation Releases ATP via Pannexin Channels in Human Pulmonary Fibroblasts by Rahman, Mozibur, Sun, Rui, Mukherjee, Subhendu, Nilius, Bernd, Janssen, Luke J

“…We previously described several ionic conductances in human pulmonary fibroblasts, including one activated by two structurally distinct TRPV4 (transient…”
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Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance by Lebeau, Paul F., Byun, Jae Hyun, Platko, Khrystyna, Saliba, Paul, Sguazzin, Matthew, MacDonald, Melissa E., Paré, Guillaume, Steinberg, Gregory R., Janssen, Luke J., Igdoura, Suleiman A., Tarnopolsky, Mark A., Wayne Chen, S. R., Seidah, Nabil G., Magolan, Jakob, Austin, Richard C.

“…Evidence suggests that caffeine (CF) reduces cardiovascular disease (CVD) risk. However, the mechanism by which this occurs has not yet been uncovered. Here,…”
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Disruption of Calcium Signaling in Fibroblasts and Attenuation of Bleomycin-Induced Fibrosis by Nifedipine by Mukherjee, Subhendu, Ayaub, Ehab A, Murphy, James, Lu, Chao, Kolb, Martin, Ask, Kjetil, Janssen, Luke J

“…Fibrotic lung disease afflicts millions of people; the central problem is progressive lung destruction and remodeling. We have shown that external growth…”
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Topical therapy with negative allosteric modulators of the calcium-sensing receptor (calcilytics) for the management of asthma: the beginning of a new era? by Riccardi, Daniela, Ward, Jeremy Pt, Yarova, Polina L, Janssen, Luke J, Lee, Tak Hong, Ying, Sun, Corrigan, Chris J

“…In this review article we present the evidence to date supporting the role of the calcium-sensing receptor (CaSR) as a key, pluripotential molecular trigger…”
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Isoprostanes and Lung Vascular Pathology by Janssen, Luke J

“…Isoprostanes are products of peroxidative attack of membrane lipids. As such, they accumulate to substantial levels in conditions of oxidative stress,…”
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Transforming growth factor-β evokes Ca2+ waves and enhances gene expression in human pulmonary fibroblasts by Mukherjee, Subhendu, Kolb, Martin R J, Duan, Fuqin, Janssen, Luke J

“…Fibroblasts maintain the structural framework of animal tissue by synthesizing extracellular matrix molecules. Chronic lung diseases are characterized in part…”
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The TRPV1 channel in rodents is a major target for antinociceptive effect of the probiotic Lactobacillus reuteri DSM 17938 by Perez‐Burgos, Azucena, Wang, Lu, McVey Neufeld, Karen‐Anne, Mao, Yu‐Kang, Ahmadzai, Mustafa, Janssen, Luke J., Stanisz, Andrew M., Bienenstock, John, Kunze, Wolfgang A.

“…Key points Certain probiotic bacteria have been shown to reduce distension‐dependent gut pain, but the mechanisms involved remain obscure. Live luminal…”
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Airway smooth muscle electrophysiology in a state of flux? by Janssen, Luke J

“…Activation of chloride currents and release of internally sequestered Ca(2+) in airway smooth muscle have long been associated with excitation and contraction…”
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Electrophysiological characterization of voltage-dependent calcium currents and TRPV4 currents in human pulmonary fibroblasts by Rahman, Mozibur, Mukherjee, Subhendu, Sheng, Wei, Nilius, Bernd, Janssen, Luke J

“…We have presented indirect evidence of a key role for voltage-dependent Ca(2+) currents in TGFβ-induced synthetic function in human pulmonary fibroblast (HPF),…”
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Airway smooth muscle as a target of asthma therapy: history and new directions by Janssen, Luke J, Killian, Kieran

“…Ultimately, asthma is a disease characterized by constriction of airway smooth muscle (ASM). The earliest approach to the treatment of asthma comprised the use…”
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Platelet derived growth factor-evoked Ca2+ wave and matrix gene expression through phospholipase C in human pulmonary fibroblast by Mukherjee, Subhendu, Duan, Fuqin, Kolb, Martin R.J., Janssen, Luke J.

“…The primary role of fibroblasts is production and degradation of extracellular matrix, and thus it helps in the structural framework of tissues. The close…”
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Modulation of human airway smooth muscle biology by human adipocytes by Giesler, Amanda, Mukherjee, Manali, Radford, Katherine, Janssen, Luke, Nair, Parameswaran

“…Asthma and obesity, two growing epidemics worldwide, may share an underlying causal relationship. Airway hyperresponsiveness (AHR), a defining component of…”
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Ca 2+ /calmodulin-dependent protein kinase IIβ and IIδ mediate TGFβ-induced transduction of fibronectin and collagen in human pulmonary fibroblasts by Mukherjee, Subhendu, Sheng, Wei, Sun, Rui, Janssen, Luke J

“…It is now clear that in addition to activating several complex kinase pathways (Smad, MAP kinase, PI3 kinase), TGFβ also acts by elevating cytosolic Ca…”
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Prostaglandin E 2 inhibits profibrotic function of human pulmonary fibroblasts by disrupting Ca 2+ signaling by Mukherjee, Subhendu, Sheng, Wei, Michkov, Alexander, Sriarm, Krishna, Sun, Rui, Dvorkin-Gheva, Anna, Insel, Paul A, Janssen, Luke J

“…We have shown that calcium (Ca ) oscillations in human pulmonary fibroblasts (HPFs) contribute to profibrotic effects of transforming growth factor-β (TGF-β)…”
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The Cycling of Intracellular Calcium Released in Response to Fluid Shear Stress Is Critical for Migration-Associated Actin Reorganization in Eosinophils by Son, Kiho, Hussain, Amer, Sehmi, Roma, Janssen, Luke

“…The magnitude of eosinophil mobilization into respiratory tissues drives the severity of inflammation in several airway diseases. In classical models of…”
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Improved recovery of functionally active eosinophils and neutrophils using novel immunomagnetic technology by Son, Kiho, Mukherjee, Manali, McIntyre, Brendan A.S., Eguez, Jose C., Radford, Katherine, LaVigne, Nicola, Ethier, Caroline, Davoine, Francis, Janssen, Luke, Lacy, Paige, Nair, Parameswaran

“…Clinically relevant and reliable reports derived from in vitro research are dependent on the choice of cell isolation protocols adopted between different…”
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Ionic mechanisms and Ca(2+) regulation in airway smooth muscle contraction: do the data contradict dogma? by Janssen, Luke J

“…In general, excitation-contraction coupling in muscle is dependent on membrane depolarization and hyperpolarization to regulate the opening of…”
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The reverse mode of the Na(+)/Ca(2+) exchanger provides a source of Ca(2+) for store refilling following agonist-induced Ca(2+) mobilization by Hirota, Simon, Pertens, Evi, Janssen, Luke J

“…Agonist-induced contraction of airway smooth muscle (ASM) can be triggered by an elevation in the intracellular Ca(2+) concentration, primarily through the…”
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Differential Cellular Sensing of Fusion from within and Fusion from without during Virus Infection by Hare, David N, Murdza, Tetyana, Collins, Susan, Schulz, Katharina, Mukherjee, Subhendu, de Antueno, Roberto, Janssen, Luke, Duncan, Roy, Mossman, Karen L

“…The physical entry of virus particles into cells triggers an innate immune response that is dependent on both calcium and nucleic acid sensors, with particles…”
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