Search Results - "Janssen, J A M L"

The IGSF1 Deficiency Syndrome: Characteristics of Male and Female Patients by Joustra, S. D, Schoenmakers, N, Persani, L, Campi, I, Bonomi, M, Radetti, G, Beck-Peccoz, P, Zhu, H, Davis, T. M. E, Sun, Y, Corssmit, E. P, Appelman-Dijkstra, N. M, Heinen, C. A, Pereira, A. M, Varewijck, A. J, Janssen, J. A. M. J. L, Endert, E, Hennekam, R. C, Lombardi, M. P, Mannens, M. M. A. M, Bak, B, Bernard, D. J, Breuning, M. H, Chatterjee, K, Dattani, M. T, Oostdijk, W, Biermasz, N. R, Wit, J. M, van Trotsenburg, A. S. P

“…Context: Ig superfamily member 1 (IGSF1) deficiency was recently discovered as a novel X-linked cause of central hypothyroidism (CeH) and macro-orchidism…”
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Overnutrition, Hyperinsulinemia and Ectopic Fat: It Is Time for A Paradigm Shift in the Management of Type 2 Diabetes by Janssen, Joseph A M J L

“…The worldwide incidence of prediabetes/type 2 has continued to rise the last 40 years. In the same period, the mean daily energy intake has increased, and the…”
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An early diagnostic tool for diabetic peripheral neuropathy in rats by Kambiz, Shoista, van Neck, Johan W, Cosgun, Saniye G, van Velzen, Marit H N, Janssen, Joop A M J L, Avazverdi, Naim, Hovius, Steven E R, Walbeehm, Erik T

“…The skin's rewarming rate of diabetic patients is used as a diagnostic tool for early diagnosis of diabetic neuropathy. At present, the relationship between…”
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Addition of insulin glargine or NPH insulin to metformin monotherapy in poorly controlled type 2 diabetic patients decreases IGF-I bioactivity similarly by Varewijck, A. J., Janssen, J. A. M. J. L., Vähätalo, M., Hofland, L. J., Lamberts, S. W. J., Yki-Järvinen, H.

“…Aims/hypothesis The aim of this study was to compare IGF-I bioactivity 36 weeks after the addition of insulin glargine (A21Gly,B31Arg,B32Arg human insulin) or…”
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The Impact of Westernization on the Insulin/IGF-I Signaling Pathway and the Metabolic Syndrome: It Is Time for Change by Janssen, Joseph A M J L

“…The metabolic syndrome is a cluster of overlapping conditions resulting in an increased incidence of type 2 diabetes, cardiovascular disease, and cancer. In…”
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Administration of Acylated Ghrelin Reduces Insulin Sensitivity, Whereas the Combination of Acylated Plus Unacylated Ghrelin Strongly Improves Insulin Sensitivity by Gauna, C., Meyler, F. M., Janssen, J. A. M. J. L., Delhanty, P. J. D., Abribat, T., van Koetsveld, P., Hofland, L. J., Broglio, F., Ghigo, E., van der Lely, A. J.

“…We investigated the metabolic actions of ghrelin in humans by examining the effects of acute administration of acylated ghrelin, unacylated ghrelin, and the…”
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How to Position Pasireotide LAR Treatment in Acromegaly by Coopmans, Eva C, Muhammad, Ammar, van der Lely, Aart J, Janssen, Joseph A M J L, Neggers, Sebastian J C M M

“…Abstract Context Pasireotide long-acting release (LAR) is a somatostatin multireceptor ligand, and in the current consensus criteria pasireotide LAR is…”
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Pasireotide Responsiveness in Acromegaly Is Mainly Driven by Somatostatin Receptor Subtype 2 Expression by Muhammad, Ammar, Coopmans, Eva C, Gatto, Federico, Franck, Sanne E, Janssen, Joseph A M J L, van der Lely, Aart Jan, Hofland, Leo J, Neggers, Sebastian J C M M

“…The response to first-generation somatostatin receptor ligands (SRLs) treatment in acromegaly correlates with expression of somatostatin receptor subtype 2…”
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The Introduction of the IDS-iSYS Total IGF-1 Assay May Have Far-Reaching Consequences for Diagnosis and Treatment of GH Deficiency by Varewijck, A. J, Lamberts, S. W. J, van der Lely, A. J, Neggers, S. J. C. M. M, Hofland, L. J, Janssen, J. A. M. J. L

“…Context: IGF-1 measurements are used for screening and monitoring GH deficiency (GHD) and acromegaly. Objective: Our objective was to study whether the…”
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Unacylated ghrelin acts as a potent insulin secretagogue in glucose-stimulated conditions by Gauna, Carlotta, Kiewiet, Rosalie M, Janssen, Joop A M J L, van de Zande, Bedette, Delhanty, Patric J D, Ghigo, Ezio, Hofland, Leo J, Themmen, Axel P N, van der Lely, Aart Jan

“…Acylated and unacylated ghrelin (AG and UAG) are gut hormones that exert pleiotropic actions, including regulation of insulin secretion and glucose metabolism…”
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Hyperinsulinemia and Its Pivotal Role in Aging, Obesity, Type 2 Diabetes, Cardiovascular Disease and Cancer by Janssen, Joseph A. M. J. L.

“…For many years, the dogma has been that insulin resistance precedes the development of hyperinsulinemia. However, recent data suggest a reverse order and place…”
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Insulin-like Growth Factor-I Receptor and Thyroid-Associated Ophthalmopathy by Smith, Terry J, Janssen, Joseph A M J L

“…Abstract Thyroid-associated ophthalmopathy (TAO) is a complex disease process presumed to emerge from autoimmunity occurring in the thyroid gland, most…”
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Long-Term Efficacy and Safety of Pegvisomant in Combination With Long-Acting Somatostatin Analogs in Acromegaly by Neggers, S. J. C. M. M, Franck, S. E, de Rooij, F. W. M, Dallenga, A. H. G, Poublon, R. M. L, Feelders, R. A, Janssen, J. A. M. J. L, Buchfelder, M, Hofland, L. J, Jørgensen, J. O. L, van der Lely, A. J

“…Background: Treatment for acromegaly patients with long-acting somatotropin release-inhibiting factor (LA-SRIF) often does not result in complete normalization…”
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Soluble Klotho: a possible predictor of quality of life in acromegaly patients by Coopmans, Eva C., El-Sayed, Nour, Frystyk, Jan, Magnusson, Nils E., Jørgensen, Jens O. L., van der Lely, Aart-Jan, Janssen, Joop A. M. J. L., Muhammad, Ammar, Neggers, Sebastian J. C. M. M.

“…Purpose Although quality of life (QoL) is improved in patients with acromegaly after disease control, QoL correlates only weakly with traditional biomarkers…”
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Ghrelin Stimulates, Whereas Des-Octanoyl Ghrelin Inhibits, Glucose Output by Primary Hepatocytes by Gauna, Carlotta, Delhanty, Patric J. D., Hofland, Leo J., Janssen, Joop A. M. J. L., Broglio, Fabio, Ross, Richard J. M., Ghigo, Ezio, van der Lely, Aart Jan

“…Ghrelin exerts various metabolic activities, including regulation of glucose levels in humans. To verify whether the glucose response to ghrelin reflects a…”
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Endogenous Hormones and Carotid Atherosclerosis in Elderly Men by van den Beld, A. W., Bots, M. L., Janssen, J. A. M. L. L., Pols, H. A. P., Lamberts, S. W. J., Grobbee, D. E.

“…The aging process is characterized by a number of gradual changes in circulating hormone concentrations as well as a gradual increase in the degree of…”
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Circulating IgGs May Modulate IGF-I Receptor Stimulating Activity in a Subset of Patients With Graves' Ophthalmopathy by Varewijck, Aimee J, Boelen, Anita, Lamberts, Steven W. J, Fliers, Eric, Hofland, Leo J, Wiersinga, Wilmar M, Janssen, Joseph A. M. J. L

“…Context: There is a close association between levels of TSH binding inhibitory immunoglobulins (TBIIs) and Graves' ophthalmopathy (GO). In addition to the TSH…”
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New Insights into the Role of Insulin and Hypothalamic-Pituitary-Adrenal (HPA) Axis in the Metabolic Syndrome by Janssen, Joseph A. M. J. L.

“…Recent data suggests that (pre)diabetes onset is preceded by a period of hyperinsulinemia. Consumption of the “modern” Western diet, over-nutrition, genetic…”
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Potency of Full-Length MGF to Induce Maximal Activation of the IGF-I R Is Similar to Recombinant Human IGF-I at High Equimolar Concentrations by Janssen, Joseph A M J L, Hofland, Leo J, Strasburger, Christian J, van den Dungen, Elisabeth S R, Thevis, Mario

“…To compare full-length mechano growth factor (full-length MGF) with human recombinant insulin-like growth factor-I (IGF-I) and human recombinant insulin (HI)…”
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A polymorphic CA repeat in the IGF-I gene is associated with gender-specific differences in body height, but has no effect on the secular trend in body height by Rietveld, I., Janssen, J. A. M. J. L., Van Rossum, E. F. C., Houwing-Duistermaat, J. J., Rivadeneira, F., Hofman, A., Pols, H. A. P., Van Duijn, C. M., Lamberts, S. W. J.

“…Summary objective  A polymorphism near the promoter region of the IGF‐I gene has been associated with serum IGF‐I levels, age‐related decline of serum IGF‐I…”
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