Search Results - "Janssen, George"

Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damage by Shi, Jing, Knevel, Rachel, Suwannalai, Parawee, van der Linden, Michael P, Janssen, George M. C, van Veelen, Peter A, Levarht, Nivine E. W, van der Helm-van Mil, Annette H. M, Cerami, Anthony, Huizinga, Tom W. J, Toes, Rene E. M, Trouw, Leendert A

“…Autoimmune responses against posttranslationally modified antigens are a hallmark of several autoimmune diseases. For example, antibodies against citrullinated…”
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An ER-Associated Pathway Defines Endosomal Architecture for Controlled Cargo Transport by Jongsma, Marlieke L.M., Berlin, Ilana, Wijdeven, Ruud H.M., Janssen, Lennert, Janssen, George M.C., Garstka, Malgorzata A., Janssen, Hans, Mensink, Mark, van Veelen, Peter A., Spaapen, Robbert M., Neefjes, Jacques

“…Through a network of progressively maturing vesicles, the endosomal system connects the cell’s interior with extracellular space. Intriguingly, this network…”
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Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C‑Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos by Kooij, Raymond, Liu, Sijia, Sapmaz, Aysegul, Xin, Bo-Tao, Janssen, George M. C, van Veelen, Peter A, Ovaa, Huib, Dijke, Peter ten, Geurink, Paul P

“…Many reagents have emerged to study the function of specific enzymes in vitro. On the other hand, target specific reagents are scarce or need improvement,…”
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Discovery of an essential nucleotidylating activity associated with a newly delineated conserved domain in the RNA polymerase-containing protein of all nidoviruses by Lehmann, Kathleen C, Gulyaeva, Anastasia, Zevenhoven-Dobbe, Jessika C, Janssen, George M C, Ruben, Mark, Overkleeft, Hermen S, van Veelen, Peter A, Samborskiy, Dmitry V, Kravchenko, Alexander A, Leontovich, Andrey M, Sidorov, Igor A, Snijder, Eric J, Posthuma, Clara C, Gorbalenya, Alexander E

“…RNA viruses encode an RNA-dependent RNA polymerase (RdRp) that catalyzes the synthesis of their RNA(s). In the case of positive-stranded RNA viruses belonging…”
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Gcn5 and Esa1 function as histone crotonyltransferases to regulate crotonylation-dependent transcription by Kollenstart, Leonie, de Groot, Anton J.L., Janssen, George M.C., Cheng, Xue, Vreeken, Kees, Martino, Fabrizio, Côté, Jacques, van Veelen, Peter A., van Attikum, Haico

“…Histone post-translational modifications (PTMs) are critical for processes such as transcription. The more notable among these are the nonacetyl histone lysine…”
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Carbamylation and antibodies against carbamylated proteins in autoimmunity and other pathologies by Shi, Jing, van Veelen, Peter A, Mahler, Michael, Janssen, George M.C, Drijfhout, Jan W, Huizinga, Tom W.J, Toes, Rene E.M, Trouw, Leendert A

“…Abstract Carbamylation is a non-enzymatic post-translational modification in which cyanate binds to molecules containing primary amine or thiol groups and…”
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N-terminal acetylation can stabilize proteins independent of their ubiquitination by van de Kooij, Bert, de Vries, Evert, Rooswinkel, Rogier W., Janssen, George M. C., Kok, Frédérique K., van Veelen, Peter A., Borst, Jannie

“…The majority of proteins in mammalian cells are modified by covalent attachment of an acetyl-group to the N-terminus (Nt-acetylation). Paradoxically,…”
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Extensive glycosylation of ACPA-IgG variable domains modulates binding to citrullinated antigens in rheumatoid arthritis by Rombouts, Yoann, Willemze, Annemiek, van Beers, Joyce J B C, Shi, Jing, Kerkman, Priscilla F, van Toorn, Linda, Janssen, George M C, Zaldumbide, Arnaud, Hoeben, Rob C, Pruijn, Ger J M, Deelder, André M, Wolbink, Gertjan, Rispens, Theo, van Veelen, Peter A, Huizinga, Tom W J, Wuhrer, Manfred, Trouw, Leendert A, Scherer, Hans U, Toes, René E M

“…To understand the molecular features distinguishing anti-citrullinated protein antibodies (ACPA) from 'conventional' antibodies in rheumatoid arthritis (RA)…”
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Development of a DUB-selective fluorogenic substrate by Gjonaj, Lorina, Sapmaz, Aysegul, Flierman, Dennis, Janssen, George M. C, van Veelen, Peter A, Ovaa, Huib

“…Ubiquitination is a post-translational modification that is involved in a plethora of cellular processes. Target proteins can be specifically modified with a…”
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Site-Specific Glycosylation Mapping of Fc Gamma Receptor IIIb from Neutrophils of Individual Healthy Donors by Wojcik, Iwona, Sénard, Thomas, de Graaf, Erik L, Janssen, George M. C, de Ru, Arnoud H, Mohammed, Yassene, van Veelen, Peter A, Vidarsson, Gestur, Wuhrer, Manfred, Falck, David

“…Fc gamma receptors (FcγRs) translate antigen recognition by immunoglobulin G (IgG) into various immune responses. A better understanding of this key element of…”
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first step of peptide selection in antigen presentation by MHC class I molecules by Garstka, Malgorzata A., Fish, Alexander, Celie, Patrick H. N., Joosten, Robbie P., Janssen, George M. C., Berlin, Ilana, Hoppes, Rieuwert, Stadnik, Magda, Janssen, Lennert, Ovaa, Huib, van Veelen, Peter A., Perrakis, Anastassis, Neefjes, Jacques

“…Significance MHC class I molecules select and present a limited set of peptides from a broad repertoire provided by TAP. How MHC class I makes this selection…”
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A flexible MHC class I multimer loading system for large-scale detection of antigen-specific T cells by Luimstra, Jolien J, Garstka, Malgorzata A, Roex, Marthe C J, Redeker, Anke, Janssen, George M C, van Veelen, Peter A, Arens, Ramon, Falkenburg, J H Frederik, Neefjes, Jacques, Ovaa, Huib

“…Adaptive immunity is initiated by T cell recognition of specific antigens presented by major histocompatibility complexes (MHCs). MHC multimer technology has…”
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Proinsulin degradation and presentation of a proinsulin B-chain autoantigen involves ER-associated protein degradation (ERAD)-enzyme UBE2G2 by Cremer, Tom, Hoelen, Hanneke, van de Weijer, Michael L, Janssen, George M, Costa, Ana I, van Veelen, Peter A, Lebbink, Robert Jan, Wiertz, Emmanuel J H J

“…Type 1 diabetes (T1D) is characterized by HLA class I-mediated presentation of autoantigens on the surface of pancreatic β-cells. Recognition of these…”
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Human VAPome Analysis Reveals MOSPD1 and MOSPD3 as Membrane Contact Site Proteins Interacting with FFAT-Related FFNT Motifs by Cabukusta, Birol, Berlin, Ilana, van Elsland, Daphne M., Forkink, Iris, Spits, Menno, de Jong, Anja W.M., Akkermans, Jimmy J.L.L., Wijdeven, Ruud H.M., Janssen, George M.C., van Veelen, Peter A., Neefjes, Jacques

“…Membrane contact sites (MCS) are intracellular regions where two organelles come closer to exchange information and material. The majority of the endoplasmic…”
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The tumor suppressor MIR139 is silenced by POLR2M to promote AML oncogenesis by Stavast, Christiaan J., van Zuijen, Iris, Karkoulia, Elena, Özçelik, Arman, van Hoven-Beijen, Antoinette, Leon, Leticia G., Voerman, Jane S. A., Janssen, George M. C., van Veelen, Peter A., Burocziova, Monika, Brouwer, Rutger W. W., van IJcken, Wilfred F. J., Maas, Alex, Bindels, Eric M., van der Velden, Vincent H. J., Schliehe, Christopher, Katsikis, Peter D., Alberich-Jorda, Meritxell, Erkeland, Stefan J.

“…MIR139 is a tumor suppressor and is commonly silenced in acute myeloid leukemia (AML). However, the tumor-suppressing activities of miR-139 and molecular…”
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Different classes of anti-modified protein antibodies are induced on exposure to antigens expressing only one type of modification by Kampstra, Arieke Suzanna Berendina, Dekkers, Jacqueline Stephanie, Volkov, Mikhail, Dorjée, Annemarie L, Hafkenscheid, Lise, Kempers, Ayla C, van Delft, Myrthe, Kissel, Theresa, Reijm, Sanne, Janssen, George M C, van Veelen, Peter A, Bang, Holger, Huizinga, Tom W J, Trouw, Leendert A, van der Woude, Diane, Toes, René E M

“…Autoantibodies against post-translationally modified proteins (anti-modified protein antibodies or AMPAs) are a hallmark of rheumatoid arthritis (RA). A…”
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Virus-Associated CD8 + T-Cells Are Not Activated Through Antigen-Mediated Interaction Inside Atherosclerotic Lesions by de Jong, Maaike J M, Schaftenaar, Frank H, Depuydt, Marie A C, Lozano Vigario, Fernando, Janssen, George M C, Peeters, Judith A H M, Goncalves, Lauren, Wezel, Anouk, Smeets, Harm J, Kuiper, Johan, Bot, Ilze, van Veelen, Peter, Slütter, Bram

“…Viral infections have been associated with the progression of atherosclerosis and CD8 T-cells directed against common viruses, such as influenza, Epstein-Barr…”
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Retinal Proteomics of a Mouse Model of Dystroglycanopathies Reveals Molecular Alterations in Photoreceptors by Uribe, Mary Luz, Martín-Nieto, José, Quereda, Cristina, Rubio-Fernández, Marcos, Cruces, Jesús, Janssen, George M. C, de Ru, Arnoud H, van Veelen, Peter A, Hensbergen, Paul J

“…Mutations in the POMT1 gene, encoding a protein O-mannosyltransferase essential for α-dystroglycan (α-DG) glycosylation, are frequently observed in a group of…”
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RNF26 binds perinuclear vimentin filaments to integrate ER and endolysosomal responses to proteotoxic stress by Cremer, Tom, Voortman, Lenard M, Bos, Erik, Jongsma, Marlieke LM, ter Haar, Laurens R, Akkermans, Jimmy JLL, Talavera Ormeño, Cami MP, Wijdeven, Ruud HM, de Vries, Jelle, Kim, Robbert Q, Janssen, George MC, van Veelen, Peter A, Koning, Roman I, Neefjes, Jacques, Berlin, Ilana

“…Proteotoxic stress causes profound endoplasmic reticulum (ER) membrane remodeling into a perinuclear quality control compartment (ERQC) for the degradation of…”
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Epigenetics Identifier screens reveal regulators of chromatin acylation and limited specificity of acylation antibodies by Kollenstart, Leonie, van der Horst, Sophie C., Vreeken, Kees, Janssen, George M. C., Martino, Fabrizio, Vlaming, Hanneke, van Veelen, Peter A., van Leeuwen, Fred, van Attikum, Haico

“…The collection of known posttranslational modifications (PTMs) has expanded rapidly with the identification of various non-acetyl histone lysine acylations,…”
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