Rapid-melt DNP for multidimensional and heteronuclear high-field NMR experiments

Rapid-melt DNP for multidimensional and heteronuclear high-field NMR experiments

[Display omitted] •Rapid-melt DNP provides solid-state enhancements in the liquid-state at high field.•The experiments can be repeated efficiently, as the sample composition does not change.•Multidimensional and heteronuclear NMR spectra can be recorded with high sensitivity.•The setup can be used t...

Full description

Saved in:
Bibliographic Details
Published in:Journal of magnetic resonance (1997) Vol. 310; p. 106656
Main Authors: van Meerten, S.G.J., Janssen, G.E., Kentgens, A.P.M.
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01-01-2020
Subjects:
DNP
Dynamic nuclear polarization
Multidimensional
NMR
Nuclear magnetic resonance
Rapid melt
Stripline NMR
Multidimensional
NMR
Rapid melt
DNP
Nuclear magnetic resonance
Dynamic nuclear polarization
Stripline NMR
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:[Display omitted] •Rapid-melt DNP provides solid-state enhancements in the liquid-state at high field.•The experiments can be repeated efficiently, as the sample composition does not change.•Multidimensional and heteronuclear NMR spectra can be recorded with high sensitivity.•The setup can be used to investigate DNP mechanisms. Low sensitivity is the main limitation of NMR for efficient chemical analysis of mass-limited samples. Hyperpolarization techniques such as Dynamic Nuclear Polarization (DNP) have greatly improved the efficiency of NMR experiments. In this manuscript, we demonstrate a 400 MHz rapid-melt DNP setup. With this setup it is possible to perform liquid-state NMR experiments with solid-state DNP enhancement at high magnetic field. Sample volumes of 100 nL in fused-silica capillaries are detected using a stripline microcoil. Due to the small heat capacity of these samples it is possible to melt them with relatively low relaxation losses. With this 400 MHz setup, proton enhancements of up to −175 have been obtained in the liquid-state. The probe is double tuned, so it can be used for heteronuclear DNP-NMR and since the sample composition does not change during the experiment, it is possible to perform signal averaging and multidimensional experiments. This type of rapid-melt DNP setup thus allows for most types of liquid-state NMR experiments to be combined with efficient solid-state DNP. This makes rapid-melt DNP an interesting method for high-throughput chemical analysis of mass-limited samples.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1090-7807
1096-0856
DOI:10.1016/j.jmr.2019.106656