Follow-up of children born after ICSI with epididymal spermatozoa

Follow-up of children born after ICSI with epididymal spermatozoa

BACKGROUND To evaluate the safety of ICSI with epididymal sperm, this study compared children born after ICSI treatment with epididymal sperm and children conceived after IVF and ICSI with ejaculated sperm. Additionally, the results of a multidisciplinary, multicentre follow-up of the children conce...

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Bibliographic Details
Published in:Human reproduction (Oxford) Vol. 26; no. 7; pp. 1759 - 1767
Main Authors: Woldringh, G.H., Horvers, M., Janssen, A.J.W.M., Reuser, J.J.C.M., de Groot, S.A.F., Steiner, K., D'Hauwers, K.W., Wetzels, A.M.M., Kremer, J.A.M.
Format: Journal Article
Language:English
Published: Oxford Oxford University Press 01-07-2011
Subjects:
Biological and medical sciences
Child
Congenital Abnormalities - epidemiology
Epididymis - cytology
Female
Fertilization in Vitro - adverse effects
Fertilization in Vitro - methods
Follow-Up Studies
Gynecology. Andrology. Obstetrics
Humans
Male
Medical sciences
Pregnancy
Pregnancy Outcome
Prospective Studies
Risk Assessment
Sperm Injections, Intracytoplasmic - adverse effects
Sperm Injections, Intracytoplasmic - methods
Sperm Retrieval
Spermatozoa
Twins
follow-up
malformations
ICSI
epididymal sperm
Human
Spermatozoa
Intracytoplasmic sperm injection
Semen
Assisted procreation
Male genital duct
Germinal cell
Birth
Male genital system
Vertebrata
Epididymis
Mammalia
Surveillance
Malformation
Child
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Summary:BACKGROUND To evaluate the safety of ICSI with epididymal sperm, this study compared children born after ICSI treatment with epididymal sperm and children conceived after IVF and ICSI with ejaculated sperm. Additionally, the results of a multidisciplinary, multicentre follow-up of the children conceived with epididymal sperm at 2 years of age are described. METHODS This follow-up study included 378 children conceived after ICSI with epididymal sperm (percutaneous epididymal sperm aspiration: PESA group) and a control group of 1192 IVF and 1126 ICSI (with ejaculated sperm) children, all with a gestational age of 20 weeks or more. Questionnaires were sent at birth, 1 year and 4 years of age, collecting data on parental, pregnancy and child factors. A total of 148 PESA children were assessed at 2 years of age for motor performance, mental- and language development and compared with the Dutch norms. RESULTS PESA children showed no increased risks for stillbirths, total deaths and malformations. They also did not differ from IVF and ICSI children in gender rate, birthweight and gestational age. The mental Bayley score was higher (P < 0.05) for PESA singletons and parents reported fewer (P < 0.05) behavioural problems in the PESA group than the Dutch reference group. The scores for syntactic and lexical development for the PESA singletons were better (P < 0.05) than the Dutch standards. CONCLUSIONS ICSI with epididymal sperm does not lead to more stillbirths or congenital malformations in comparison to IVF and ICSI with ejaculated sperm and does not lead to poor development in comparison with the Dutch reference group.
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ISSN:0268-1161
1460-2350
DOI:10.1093/humrep/der136