Search Results - "Jansen Steur, Ernst N.H."
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Staging of brain pathology related to sporadic Parkinson’s disease
Published in Neurobiology of aging (01-03-2003)“…Sporadic Parkinson’s disease involves multiple neuronal systems and results from changes developing in a few susceptible types of nerve cells. Essential for…”
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Expression of nicotinic acetylcholine receptors in Alzheimer’s disease: postmortem investigations and experimental approaches
Published in Behavioural brain research (01-08-2000)“…Nicotinic ligand binding studies have shown rather early that the cholinoceptive system is affected in Alzheimer’s disease (AD). Today, molecular…”
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Quantitative assessment of nicotinic acetylcholine receptor proteins in the cerebral cortex of Alzheimer patients
Published in Brain research. Molecular brain research. (29-03-2000)“…Cholinergic transmission has for long been known to be one of the most severely affected systems in Alzheimer's disease (AD), resulting clinically in massive…”
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Elevated concentration of cerebrospinal fluid tissue transglutaminase in Parkinson's disease indicating apoptosis
Published in Movement disorders (01-10-2004)“…Tissue transglutaminase (tTG) is activated during the apoptotic cell death cascade and plays a key role in the formation of apoptotic bodies. We found…”
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Cellular Expression of α7 Nicotinic Acetylcholine Receptor Protein in the Temporal Cortex in Alzheimer's and Parkinson's Disease— A Stereological Approach
Published in Neurobiology of disease (01-12-2000)“…Cognitive deficits in Alzheimer's and Parkinson's disease are closely related to disturbed cholinergic transmission. The decrease of nicotinic acetylcholine…”
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Increase of Parkinson disability after fluoxetine medication
Published in Neurology (1993)“…Depression is a major clinical feature of Parkinson's disease. We report the increased amount of motor disability in four patients with idiopathic Parkinson's…”
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Absence of heparan sulfate proteoglycans in Lewy bodies and Lewy neurites in Parkinson's disease brains
Published in Journal of Alzheimer's disease (01-10-2004)“…alpha-Synuclein is the major constituent of Lewy bodies and Lewy neurites in Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Relatively little is…”
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The cholinergic system in Alzheimerʼs disease
Published in Current opinion in psychiatry (01-05-2002)“…Aging is a crucial risk factor for irreversible and progressive neurodegenerative disorders, such as Alzheimerʼs disease. The number of people (prevalence)…”
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Parvalbumin-containing interneurons of the human cerebral cortex express nicotinic acetylcholine receptor proteins
Published in Journal of chemical neuroanatomy (01-05-2001)“…Cholinergic fibers from the basal forebrain are known to contact cholinoceptive cortical pyramidal neurons. Recent electrophysiological studies have revealed…”
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Pathological features of cerebral cortical capillaries are doubled in Alzheimer's disease and Parkinson's disease
Published in Acta neuropathologica (01-10-2000)“…Cerebral capillaries represent a major interface between the general circulation and the central nervous system and are responsible for sufficient and…”
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Argyrophilic grain disease and Alzheimer's disease are distinguished by their different distribution of tau protein isoforms
Published in Acta neuropathologica (01-10-2002)“…Prominent neuronal and glial tau filamentous inclusions are hallmarks of neurodegenerative tauopathies, among them Alzheimer's disease (AD), progressive…”
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Familial cortical tremor with epilepsy and cerebellar pathological findings
Published in Movement disorders (01-02-2004)“…The clinical and neuropathological findings in a patient with familial cortical tremor with epilepsy (FCTE) are described. Clinically, the patient showed…”
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Parkinson's disease : affection of brain stem nuclei controlling premotor and motor neurons of the somatomotor system
Published in Acta neuropathologica (01-05-2000)“…Pathological changes which consistently develop in the lower brain stem of patients suffering from Parkinson's disease are described against the background of…”
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Similar Ultrastructural Breakdown of Cerebrocortical Capillaries in Alzheimer's Disease, Parkinson's Disease, and Experimental Hypertension: What is the Functional Link?
Published in Annals of the New York Academy of Sciences (01-04-2000)“…: The brain, as an intensely active organ, is highly dependent on a sufficient nutrient and oxygen availability in order to reach its optimal working capacity…”
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Decreased concentration of Annexin V in Parkinsonian cerebrospinal fluid: Speculation on the underlying cause
Published in Movement disorders (01-11-1999)“…Circumstantial evidence suggests that increased apoptosis is responsible for the loss of dopaminergic nigrostriatal neurons in Parkinson's disease (PD). It is…”
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Apolipoprotein E genotyping in patients with neurodegenerative diseases
Published in Clinical biochemistry (01-07-1997)“…Objectives: There is a growing demand to perform apolipoprotein E (Apo-E) genotyping on neuropathologic archive material. Due to the extremely long fixation…”
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