Search Results - "Jansen, Nicolaas J"
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Refractory septic shock in children: a European Society of Paediatric and Neonatal Intensive Care definition
Published in Intensive care medicine (01-12-2016)“…Purpose Although overall paediatric septic shock mortality is decreasing, refractory septic shock (RSS) is still associated with high mortality. A definition…”
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The digestive tract as the origin of systemic inflammation
Published in Critical care (London, England) (18-10-2016)“…Failure of gut homeostasis is an important factor in the pathogenesis and progression of systemic inflammation, which can culminate in multiple organ failure…”
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Paediatric sepsis: old wine in new bottles?
Published in Intensive care medicine (01-11-2017)“…The recent year marked a milestone in the field of sepsis in adults, with the revised Sepsis-3 definitions [1] and the updated Surviving Sepsis Campaign [2]…”
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Neuromonitoring, neuroimaging, and neurodevelopmental follow-up practices in neonatal congenital heart disease: a European survey
Published in Pediatric research (01-01-2023)“…Background Brain injury and neurodevelopmental impairment remain a concern in children with complex congenital heart disease (CHD). A practice guideline on…”
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Neurological Injury After Neonatal Cardiac Surgery: A Randomized, Controlled Trial of 2 Perfusion Techniques
Published in Circulation (New York, N.Y.) (14-01-2014)“…BACKGROUND—Complex neonatal cardiac surgery is associated with cerebral injury. In particular, aortic arch repair, requiring either deep hypothermic…”
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Genetic variability among complete human respiratory syncytial virus subgroup A genomes: bridging molecular evolutionary dynamics and epidemiology
Published in PloS one (07-12-2012)“…Human respiratory syncytial virus (RSV) is an important cause of severe lower respiratory tract infections in infants and the elderly. In the vast majority of…”
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Intermittent intravenous paracetamol versus continuous morphine in infants undergoing cardiothoracic surgery: a multi-center randomized controlled trial
Published in Critical care (London, England) (30-04-2024)“…To determine whether intermittent intravenous (IV) paracetamol as primary analgesic would significantly reduce morphine consumption in children aged 0-3 years…”
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A Systemic Neutrophil Response Precedes Robust CD8+ T-Cell Activation during Natural Respiratory Syncytial Virus Infection in Infants
Published in Journal of Virology (01-03-2010)“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Increased Detection of Respiratory Syncytial Virus, Influenza Viruses, Parainfluenza Viruses, and Adenoviruses with Real-Time PCR in Samples from Patients with Respiratory Symptoms
Published in Journal of Clinical Microbiology (01-07-2007)“…Article Usage Stats Services JCM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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CeRebrUm and CardIac Protection with ALlopurinol in Neonates with Critical Congenital Heart Disease Requiring Cardiac Surgery with Cardiopulmonary Bypass (CRUCIAL): study protocol of a phase III, randomized, quadruple-blinded, placebo-controlled, Dutch multicenter trial
Published in Current controlled trials in cardiovascular medicine (23-02-2022)“…Neonates with critical congenital heart disease (CCHD) undergoing cardiac surgery with cardiopulmonary bypass (CPB) are at risk of brain injury that may result…”
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Perioperative and bedside cerebral monitoring identifies cerebral injury after surgical correction of congenital aortic arch obstruction
Published in Intensive care medicine (01-11-2015)Get full text
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Validation of an adapted Pediatric Sepsis Score in children admitted to PICU with invasive infection and sepsis: a retrospective analysis of a Dutch national cohort
Published in Journal of intensive care (07-06-2022)“…We validated an adapted form of the Pediatric Sepsis Score (aPSS), a disease-specific severity score available within 60 min of PICU admission, in children…”
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Deaths and end‐of‐life decisions differed between neonatal and paediatric intensive care units at the same children's hospital
Published in Acta Paediatrica (01-02-2018)“…Aim We compared neonatal deaths and end‐of‐life decisions in a neonatal intensive care unit (NICU) and paediatric intensive care unit (PICU) in a Dutch…”
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STAT3 regulates monocyte TNF-alpha production in systemic inflammation caused by cardiac surgery with cardiopulmonary bypass
Published in PloS one (10-04-2012)“…Cardiopulmonary bypass (CPB) surgery initiates a controlled systemic inflammatory response characterized by a cytokine storm, monocytosis and transient…”
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Mortality prediction models for pediatric intensive care: comparison of overall and subgroup specific performance
Published in Intensive care medicine (01-05-2013)“…Aim To validate paediatric index of mortality (PIM) and pediatric risk of mortality (PRISM) models within the overall population as well as in specific…”
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Dexamethasone attenuates VEGF expression and inflammation but not barrier dysfunction in a murine model of ventilator-induced lung injury
Published in PloS one (25-02-2013)“…Ventilator-induced lung injury (VILI) is characterized by vascular leakage and inflammatory responses eventually leading to pulmonary dysfunction. Vascular…”
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Translational gap in pediatric septic shock management: an ESPNIC perspective
Published in Annals of intensive care (28-06-2019)“…Background The Surviving Sepsis Campaign and the American College of Critical Care Medicine guidelines have provided recommendations for the management of…”
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Bedside prediction rule for infections after pediatric cardiac surgery
Published in Intensive care medicine (01-03-2012)“…Purpose Infections after pediatric cardiac surgery are a common complication, occurring in up to 30% of cases. The purpose of this study was to develop a…”
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Transcranial Doppler ultrasonography to confirm brain death : a meta-analysis
Published in Intensive care medicine (01-12-2006)“…Barbiturate therapy or hypothermia precludes proper diagnosis of brain death either clinically or by EEG. Specific intracranial flow patterns indicating…”
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Cerebral ischemia initiates an immediate innate immune response in neonates during cardiac surgery
Published in Journal of neuroinflammation (07-02-2013)“…A robust inflammatory response occurs in the hours and days following cerebral ischemia. However, little is known about the immediate innate immune response in…”
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