Search Results - "Jansen, Marc D."

Autoantibody pathogenicity in a multifocal motor neuropathy induced pluripotent stem cell-derived model by Harschnitz, Oliver, van den Berg, Leonard H., Johansen, Lill Eva, Jansen, Marc D., Kling, Sandra, Vieira de Sá, Renata, Vlam, Lotte, van Rheenen, Wouter, Karst, Henk, Wierenga, Corette J., Pasterkamp, R. Jeroen, van der Pol, W. Ludo

“…Objective We investigated the pathogenicity of immunoglobulin M (IgM) anti‐GM1 antibodies in serum from patients with multifocal motor neuropathy (MMN) using…”
Get full text

Streptococcus pneumoniae in saliva of Dutch primary school children by Wyllie, Anne L, Chu, Mei Ling J N, Schellens, Mariëlle H B, van Engelsdorp Gastelaars, Jody, Jansen, Marc D, van der Ende, Arie, Bogaert, Debby, Sanders, Elisabeth A M, Trzciński, Krzysztof

“…While nasopharyngeal sampling is the gold standard for the detection of Streptococcus pneumoniae carriage, historically seen, saliva sampling also seems highly…”
Get full text

A Comparative Study of SMN Protein and mRNA in Blood and Fibroblasts in Patients with Spinal Muscular Atrophy and Healthy Controls by Wadman, Renske I, Stam, Marloes, Jansen, Marc D, van der Weegen, Yana, Wijngaarde, Camiel A, Harschnitz, Oliver, Sodaar, Peter, Braun, Kees P J, Dooijes, Dennis, Lemmink, Henny H, van den Berg, Leonard H, van der Pol, W Ludo

“…Clinical trials to test safety and efficacy of drugs for patients with spinal muscular atrophy (SMA) are currently underway. Biomarkers that document…”
Get full text

IVIg inhibits classical pathway activity and anti-GM1 IgM-mediated complement deposition in MMN by Piepers, Sanne, Jansen, Marc D, Cats, Elisabeth A, van Sorge, Nina M, van den Berg, Leonard H, van der Pol, W.-Ludo

“…Abstract The effects of intravenous immunoglobulins (IVIg) on anti-GM1 IgM titer and function, classical complement pathway activity, and antibody–complement…”
Get full text

Anti-C2 Antibody ARGX-117 Inhibits Complement in a Disease Model for Multifocal Motor Neuropathy by Budding, Kevin, Johansen, Lill Eva, Van de Walle, Inge, Dijkxhoorn, Kim, de Zeeuw, Elisabeth, Bloemenkamp, Lauri M., Bos, Jeroen W., Jansen, Marc D., Curial, Chantall A.D., Silence, Karen, de Haard, Hans, Blanchetot, Christophe, Van de Ven, Liesbeth, Leusen, Jeanette H.W., Pasterkamp, R. Jeroen, van den Berg, Leonard H., Hack, C. Erik, Boross, Peter, van der Pol, W. Ludo

“…To determine the role of complement in the disease pathology of multifocal motor neuropathy (MMN), we investigated complement activation, and inhibition, on…”
Get full text

Methicillin-resistant Staphylococcus aureus in pigs with exudative epidermitis by van Duijkeren, Engeline, Jansen, Marc D, Flemming, S Carolien, de Neeling, Han, Wagenaar, Jaap A, Schoormans, Anky H W, van Nes, Arie, Fluit, Ad C

“…Despite a strict control program for methicillin-resistant Staphylococcus aureus (MRSA) in human medicine in the Netherlands, MRSA was cultured from exudative…”
Get full text

SCCmec typing in methicillin-resistant Staphylococcus aureus strains of animal origin by Jansen, Marc D, Box, Adrienne T A, Fluit, Ad C

Get full text

Intragenic and structural variation in the SMN locus and clinical variability in spinal muscular atrophy by Wadman, Renske I, Jansen, Marc D, Stam, Marloes, Wijngaarde, Camiel A, Curial, Chantall A D, Medic, Jelena, Sodaar, Peter, Schouten, Jan, Vijzelaar, Raymon, Lemmink, Henny H, van den Berg, Leonard H, Groen, Ewout J N, van der Pol, W Ludo

“…Abstract Clinical severity and treatment response vary significantly between patients with spinal muscular atrophy. The approval of therapies and the emergence…”
Get full text

Pharmacogenetic interactions in amyotrophic lateral sclerosis: a step closer to a cure? by van Eijk, Ruben P. A., Eijkemans, Marinus J. C., Nikolakopoulos, Stavros, Jansen, Marc D., Westeneng, Henk-Jan, van Eijk, Kristel R., van der Spek, Rick A. A., van Vugt, Joke J. F. A., Piepers, Sanne, Groeneveld, Geert-Jan, Veldink, Jan H., van den Berg, Leonard H., van Es, Michael A.

“…Genetic mutations related to amyotrophic lateral sclerosis (ALS) act through distinct pathophysiological pathways, which may lead to varying treatment…”
Get full text

Prevalence, specificity and functionality of anti-ganglioside antibodies in neuropathy associated with IgM monoclonal gammopathy by Stork, Abraham C.J, Jacobs, Bart C, Tio-Gillen, Anne P, Eurelings, Marijke, Jansen, Marc D, van den Berg, Leonard H, Notermans, Nicolette C, van der Pol, W-Ludo

“…Abstract IgM antibodies against gangliosides and their complexes were studied in sera from 54 patients with polyneuropathy and IgM monoclonal gammopathy…”
Get full text

Ganglioside-specific IgG and IgA recruit leukocyte effector functions in Guillain–Barré syndrome by van Sorge, Nina M, Yuki, Nobuhiro, Koga, Michiaki, Susuki, Keiichiro, Jansen, Marc D, van Kooten, Cees, Wokke, John H.J, van de Winkel, Jan G.J, van der Pol, W-Ludo, van den Berg, Leonard H

“…Abstract The capacity of ganglioside-specific autoantibodies to recruit leukocyte effector functions was studied. Serum samples from 87 patients with…”
Get full text

Analysis of FUS, PFN2, TDP-43, and PLS3 as potential disease severity modifiers in spinal muscular atrophy by Wadman, Renske I., Jansen, Marc D., Curial, Chantall A.D., Groen, Ewout J.N., Stam, Marloes, Wijngaarde, Camiel A., Medic, Jelena, Sodaar, Peter, van Eijk, Kristel R., Huibers, Manon M.H., van Kuik, Joyce, Lemmink, Henny H., van Rheenen, Wouter, Veldink, Jan Herman, van den Berg, Leonard H., van der Pol, W. Ludo

“…To investigate mutations in genes that are potential modifiers of spinal muscular atrophy (SMA) severity. We performed a hypothesis-based search into the…”
Get full text

Quantification of SMN protein in leucocytes from spinal muscular atrophy patients: effects of treatment with valproic acid by Piepers, Sanne, Cobben, Jan-Maarten, Sodaar, Peter, Jansen, Marc D, Wadman, Renske I, Meester-Delver, Ann, Poll-The, Bwee Tien, Lemmink, Henny H, Wokke, John H J, van der Pol, W-Ludo, van den Berg, Leonard H

“…BackgroundSpinal muscular atrophy (SMA) is caused by the homozygous deletion of the survival motor neuron (SMN)1 gene. The nearly identical SMN2 gene produces…”
Get full text

Complement activity is associated with disease severity in multifocal motor neuropathy by Vlam, Lotte, Cats, Elisabeth A, Harschnitz, Oliver, Jansen, Marc D, Piepers, Sanne, Veldink, Jan Herman, Franssen, Hessel, Stork, Abraham C.J, Heezius, Erik, Rooijakkers, Suzan H.M, Herpers, Bjorn L, van Strijp, Jos A, van den Berg, Leonard H, van der Pol, W Ludo

“…OBJECTIVE:To investigate whether high innate activity of the classical and lectin pathways of complement is associated with multifocal motor neuropathy (MMN)…”
Get full text

Severity of Guillain–Barré syndrome is associated with Fcγ Receptor III polymorphisms by van Sorge, Nina M., van der Pol, W.-Ludo, Jansen, Marc D., Geleijns, Karin P.W., Kalmijn, Sandra, Hughes, Richard A.C., Rees, Jeremy H., Pritchard, Jane, Vedeler, Christian A., Myhr, Kjell-Morten, Shaw, Chris, van Schaik, Ivo N., Wokke, John H.J., van Doorn, Pieter A., Jacobs, Bart C., van de Winkel, Jan G.J., van den Berg, Leonard H.

“…Macrophages and ganglioside-specific IgG are involved in the pathogenesis of Guillain–Barré syndrome (GBS). Leukocyte IgG receptors (FcγR) confer potent…”
Get full text

Leukocyte and complement activation by GM1-specific antibodies is associated with acute motor axonal neuropathy in rabbits by van Sorge, Nina M, Yuki, Nobuhiro, Jansen, Marc D, Nishimoto, Yukihiro, Susuki, Keiichiro, Wokke, John H.J, van de Winkel, Jan G.J, van den Berg, Leonard H, van der Pol, W-Ludo

“…Abstract Acute motor axonal neuropathy (AMAN) in humans is associated with the presence of GM1-specific antibodies. Immunization of rabbits with GM1-containing…”
Get full text

Fcγ receptor gene polymorphisms in Japanese patients with systemic lupus erythematosus: Contribution of FCGR2B to genetic susceptibility by Kyogoku, Chieko, Dijstelbloem, Hilde M., Tsuchiya, Naoyuki, Hatta, Yoko, Kato, Hitoshi, Yamaguchi, Akihiro, Fukazawa, Toru, Jansen, Marc D., Hashimoto, Hiroshi, van de Winkel, Jan G. J., Kallenberg, Cees G. M., Tokunaga, Katsushi

“…Objective Human low‐affinity Fcγ receptors (FcγR) constitute a clustered gene family located on chromosome 1q23, that consists of FcγRIIA, IIB, IIC, IIIA, and…”
Get full text

SCC mec Typing in Methicillin-Resistant Staphylococcus aureus Strains of Animal Origin by Jansen, Marc D., Box, Adrienne T.A., Fluit, Ad C.

Get full text

Evidence for non-random distribution of Fcγ receptor genotype combinations by van der Pol, W.-Ludo, Jansen, Marc D., Sluiter, Wim J., van de Sluis, Bart, Leppers-van de Straat, Fredriek G. J., Kobayashi, Tetsuo, Westendorp, Rudi G. J., Huizinga, Tom W. J., van de Winkel, Jan G. J.

“…Human IgG receptors (Fc gamma R) display considerable heterogeneity, and are crucial immune response modulating molecules.Fc gamma RIIA,Fc gamma RIIIA, andFc…”
Get full text

Evidence for non-random distribution of Fcgamma receptor genotype combinations by van der Pol, W-Ludo, Jansen, Marc D, Sluiter, Wim J, van de Sluis, Bart, Leppers-van de Straat, Fredriek G J, Kobayashi, Tetsuo, Westendorp, Rudi G J, Huizinga, Tom W J, van de Winkel, Jan G J

“…Human IgG receptors (FcgammaR) display considerable heterogeneity, and are crucial immune response modulating molecules. FcgammaRIIA, FcgammaRIIIA, and…”
Get full text