Search Results - "Jansen, Machiel"

Invasive fungal infection and impaired neutrophil killing in human CARD9 deficiency by Drewniak, Agata, Gazendam, Roel P., Tool, Anton T.J., van Houdt, Michel, Jansen, Machiel H., van Hamme, John L., van Leeuwen, Ester M.M., Roos, Dirk, Scalais, Emmanuel, de Beaufort, Carine, Janssen, Hans, van den Berg, Timo K., Kuijpers, Taco W.

“…Caspase recruitment domain–containing protein 9 (CARD9) is an adaptor molecule in the cytosol of myeloid cells, required for induction of T-helper cells…”
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A combined immunodeficiency with severe infections, inflammation, and allergy caused by ARPC1B deficiency by Volpi, Stefano, Cicalese, Maria Pia, Tuijnenburg, Paul, Tool, Anton T.J., Cuadrado, Eloy, Abu-Halaweh, Marwan, Ahanchian, Hamid, Alzyoud, Raed, Akdemir, Zeynep Coban, Barzaghi, Federica, Blank, Alexander, Boisson, Bertrand, Bottino, Cristina, Brigida, Immacolata, Caorsi, Roberta, Casanova, Jean-Laurent, Chiesa, Sabrina, Chinn, Ivan Kingyue, Dückers, Gregor, Enders, Anselm, Erichsen, Hans Christian, Forbes, Lisa R., Gambin, Tomasz, Gattorno, Marco, Karimiani, Ehsan Ghayoor, Giliani, Silvia, Gold, Michael S., Jacobsen, Eva-Maria, Jansen, Machiel H., King, Jovanka R., Laxer, Ronald M., Lupski, James R., Mace, Emily, Marcenaro, Stefania, Maroofian, Reza, Meijer, Alexander B., Niehues, Tim, Notarangelo, Luigi D., Orange, Jordan, Pannicke, Ulrich, Pearson, Chris, Picco, Paolo, Quinn, Patrick J., Schulz, Ansgar, Seeborg, Filiz, Stray-Pedersen, Asbjørg, Tawamie, Hasan, van Leeuwen, Ester M.M., Aiuti, Alessandro, Yeung, Rae, Schwarz, Klaus, Kuijpers, Taco W.

“…To the Editor: Recently, a novel syndrome of combined immunodeficiency, allergy, and “auto”inflammation caused by mutations in the ARPC1B gene has been…”
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Hematopoietic stem cell transplantation in a patient with proteasome-associated autoinflammatory syndrome (PRAAS) by Verhoeven, Dorit, Schonenberg-Meinema, Dieneke, Ebstein, Frédéric, Papendorf, Jonas J., Baars, Paul A., van Leeuwen, Ester M.M., Jansen, Machiel H., Lankester, Arjan C., van der Burg, Mirjam, Florquin, Sandrine, Maas, Saskia M., van Koningsbruggen, Silvana, Krüger, Elke, van den Berg, J. Merlijn, Kuijpers, Taco W.

“…Proteasome-associated autoinflammatory syndromes (PRAASs) form a family of recently described rare autosomal recessive disorders of disturbed proteasome…”
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Human NLRP3 inflammasome activation is Nox1-4 independent by van Bruggen, Robin, Köker, M. Yavuz, Jansen, Machiel, van Houdt, Michel, Roos, Dirk, Kuijpers, Taco W., van den Berg, Timo K.

“…The NLRP3 inflammasome can be activated by pathogen-associated molecular patterns or endogenous danger-associated molecular patterns. The activation of the…”
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Activated neutrophils exert myeloid-derived suppressor cell activity damaging T cells beyond repair by Aarts, Cathelijn E.M., Hiemstra, Ida H., Béguin, Eelke P., Hoogendijk, Arjan J., Bouchmal, Souhailla, van Houdt, Michel, Tool, Anton T.J., Mul, Erik, Jansen, Machiel H., Janssen, Hans, van Alphen, Floris P.J., de Boer, Jan-Paul, Zuur, Charlotte L., Meijer, Alexander B., van den Berg, Timo K., Kuijpers, Taco W.

“…Myeloid-derived suppressor cells (MDSCs) have the capacity to suppress T-cell–mediated immune responses and impact the clinical outcome of cancer, infections,…”
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ADAR1 Facilitates HIV-1 Replication in Primary CD4+ T Cells by Cuadrado, Eloy, Booiman, Thijs, van Hamme, John L, Jansen, Machiel H, van Dort, Karel A, Vanderver, Adeline, Rice, Gillian I, Crow, Yanick J, Kootstra, Neeltje A, Kuijpers, Taco W

“…Unlike resting CD4+ T cells, activated CD4+T cells are highly susceptible to infection of human immunodeficiency virus 1 (HIV-1). HIV-1 infects T cells and…”
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High‐throughput compound screen reveals mTOR inhibitors as potential therapeutics to reduce (auto)antibody production by human plasma cells by Tuijnenburg, Paul, aan de Kerk, Daan J., Jansen, Machiel H., Morris, Ben, Lieftink, Cor, Beijersbergen, Roderick L., Leeuwen, Ester M.M., Kuijpers, Taco W.

“…Antibody production by the B cell compartment is a crucial part of the adaptive immune response. Dysregulated antibody production in the form of autoantibodies…”
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Varicella vaccination in pediatric oncology patients without interruption of chemotherapy by van de Wetering, Marianne D, Vossen, -->Mireille T.M, Jansen, Machiel. H, Caron, Hubert N, Kuijpers, Taco W

“…Highlights • Varicella infection during chemotherapy in pediatric oncology patients still causes morbidity. • We report that varicella vaccination during…”
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Phenotypic variation in Aicardi-Goutières syndrome explained by cell-specific IFN-stimulated gene response and cytokine release by Cuadrado, Eloy, Michailidou, Iliana, van Bodegraven, Emma J, Jansen, Machiel H, Sluijs, Jacqueline A, Geerts, Dirk, Couraud, Pierre-Olivier, De Filippis, Lidia, Vescovi, Angelo L, Kuijpers, Taco W, Hol, Elly M

“…Aicardi-Goutières syndrome (AGS) is a monogenic inflammatory encephalopathy caused by mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR1, or MDA5…”
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Failure to detect functional neutrophil B helper cells in the human spleen by Nagelkerke, Sietse Quirijn, aan de Kerk, Daan Jacob, Jansen, Machiel Hugo, van den Berg, Timo Kars, Kuijpers, Taco Willem

“…A novel role for human neutrophilic granulocytes was recently described, showing that these cells, upon entering the spleen, can be reprogrammed into a…”
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Fetal exposure to HIV-1 alters chemokine receptor expression by CD4+T cells and increases susceptibility to HIV-1 by Bunders, Madeleine J., van Hamme, John L., Jansen, Machiel H., Boer, Kees, Kootstra, Neeltje A., Kuijpers, Taco W.

“…Absolute numbers of lymphocytes are decreased in uninfected infants born to HIV-1-infected women (HIV-1-exposed). Although the exact mechanism is unknown,…”
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Idiopathic CD4+ T lymphopenia without autoimmunity or granulomatous disease in the slipstream of RAG mutations by Kuijpers, Taco W., Ijspeert, Hanna, van Leeuwen, Ester M.M., Jansen, Machiel H., Hazenberg, Mette D., Weijer, Kees C., van Lier, Rene A.W., van der Burg, Mirjam

“…A girl presented during childhood with a single course of extensive chickenpox and moderate albeit recurrent pneumonia in the presence of idiopathic CD4+ T…”
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Chronic exposure of astrocytes to interferon-α reveals molecular changes related to Aicardi―Goutières syndrome by CUADRADO, Eloy, JANSEN, Machiel H, ANINK, Jasper, DE FILIPPIS, Lidia, VESCOVI, Angelo L, WATTS, Colin, ARONICA, Eleonora, HOL, Elly M, KUIJPERS, Taco W

“…Aicardi-Goutières syndrome is a genetically determined infantile encephalopathy, manifesting as progressive microcephaly, psychomotor retardation, and in ∼25%…”
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Aicardi-Goutières syndrome harbours abundant systemic and brain-reactive autoantibodies by Cuadrado, Eloy, Vanderver, Adeline, Brown, Kristy J, Sandza, Annie, Takanohashi, Asako, Jansen, Machiel H, Anink, Jasper, Herron, Brian, Orcesi, Simona, Olivieri, Ivana, Rice, Gillian I, Aronica, Eleonora, Lebon, Pierre, Crow, Yanick J, Hol, Elly M, Kuijpers, Taco W

“…Aicardi-Goutières syndrome (AGS) is an autoimmune disorder that shares similarities with systemic lupus erythematous. AGS inflammatory responses specially…”
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Pathogenic NFKB2 variant in the ankyrin repeat domain (R635X) causes a variable antibody deficiency by Tuijnenburg, Paul, Lango Allen, Hana, de Bree, Godelieve J., Savic, Sinisa, Jansen, Machiel H., Stockdale, Claire, Simeoni, Ilenia, ten Berge, Ineke J.M., van Leeuwen, Ester M.M., Thaventhiran, James E., Kuijpers, Taco W.

“…Genetic studies are identifying an increasing number of monogenic causes of Common Variable Immunodeficiency (CVID). Pathogenic variants in the C-terminus of…”
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Neutrophils acquire antigen-presenting cell features after phagocytosis of IgG-opsonized erythrocytes by Meinderts, Sanne M., Baker, Gabriella, van Wijk, Stan, Beuger, Boukje M., Geissler, Judy, Jansen, Machiel H., Saris, Anno, ten Brinke, Anja, Kuijpers, Taco W., van den Berg, Timo K., van Bruggen, Robin

“…Neutrophils are particularly well known for their antimicrobial function. Although historically they are regarded as strictly a phagocyte of the innate immune…”
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Treatment of an HLH-mimic disease based on HAVCR2 variants with absent TIM-3 expression by Tromp, Samantha A.M., Gillissen, Marijn A., Bernelot Moens, Sophie J., van Leeuwen, Ester M.M., Jansen, Machiel H., Koens, Lianne, Rutten, Caroline E., Kuijpers, Taco W.

“…[Display omitted]…”
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Transient anti-cytokine autoantibodies superimpose the hyperinflammatory response in Kawasaki disease and multisystem inflammatory syndrome in children: a comparative cohort study on correlates of disease by Netea, Stejara A., Biesbroek, Giske, van Stijn, Diana, Ijspeert, Hanna, van der Made, Caspar I., Jansen, Machiel H., Geissler, Judy, van den Berg, J.M. (Merlijn), van der Kuip, Martijn, Gruppen, Mariken P., Schonenberg-Meinema, Dieneke, Kapitein, Berber, van Furth, A.M. (Marceline) Tutu, Nagelkerke, Sietse Q., Pajkrt, Dasja, Plötz, Frans B., den Boer, M.E.J. (Lisette), Landman, Gijs W., van Houten, Marlies A., Goetschalckx, Ines, Hendriks, T., Felderhof, M.K., Weggelaar, N.M., Filippini, L., Rozendaal, L., Groeneweg, M., Nuboer, R., Bruijn, M., Dolman, K.M., Noordzij, J.G., de Winter, J.P., Vlieger, A.M., Plötz, F.B., Delemarre, L.C., Toonen, Erik J.M., van de Veerdonk, Frank L., Kuipers, Irene M., Dik, Willem A., Kuijpers, Taco W.

“…Children with SARS-CoV-2 related Multisystem Inflammatory Syndrome in Children (MIS-C) often present with clinical features that resemble Kawasaki disease…”
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Immunodeficiency, autoimmunity, and increased risk of B cell malignancy in humans with TRAF3 mutations by Rae, William, Sowerby, John M, Verhoeven, Dorit, Youssef, Mariam, Kotagiri, Prasanti, Savinykh, Natalia, Coomber, Eve L, Boneparth, Alexis, Chan, Angela, Gong, Chun, Jansen, Machiel H, du Long, Romy, Santilli, Giorgia, Simeoni, Ilenia, Stephens, Jonathan, Wu, Kejia, Zinicola, Marta, Allen, Hana Lango, Baxendale, Helen, Kumararatne, Dinakantha, Gkrania-Klotsas, Effrossyni, Scheffler Mendoza, Selma C, Yamazaki-Nakashimada, Marco Antonio, Ruiz, Laura Berrón, Rojas-Maruri, Cesar Mauricio, Lugo Reyes, Saul O, Lyons, Paul A, Williams, Anthony P, Hodson, Daniel J, Bishop, Gail A, Thrasher, Adrian J, Thomas, David C, Murphy, Michael P, Vyse, Timothy J, Milner, Joshua D, Kuijpers, Taco W, Smith, Kenneth G C

“…Tumor necrosis factor receptor-associated factor 3 (TRAF3) is a central regulator of immunity. TRAF3 is often somatically mutated in B cell malignancies, but…”
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A reversion of an IL2RG mutation in combined immunodeficiency providing competitive advantage to the majority of CD8+ T cells by Kuijpers, Taco W, van Leeuwen, Ester M M, Barendregt, Barbara H, Klarenbeek, Paul, aan de Kerk, Daan J, Baars, Paul A, Jansen, Machiel H, de Vries, Niek, van Lier, René A W, van der Burg, Mirjam

“…Mutations in the common gamma chain (γc, CD132, encoded by the IL2RG gene) can lead to B(+)T(-)NK(-) X-linked severe combined immunodeficiency, as a…”
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