Search Results - "Jansen, Ineke D.C"

Osteoblasts of calvaria induce higher numbers of osteoclasts than osteoblasts from long bone by Wan, Qilong, Schoenmaker, Ton, Jansen, Ineke D.C, Bian, Zhuan, de Vries, Teun J, Everts, Vincent

“…Abstract Several studies have demonstrated the existence of functional differences between osteoclasts harbored in different bones. The mechanisms involved in…”
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Jaw bone marrow-derived osteoclast precursors internalize more bisphosphonate than long-bone marrow precursors by Vermeer, Jenny A.F, Jansen, Ineke D.C, Marthi, Matangi, Coxon, Fraser P, McKenna, Charles E, Sun, Shuting, de Vries, Teun J, Everts, Vincent

“…Abstract Bisphosphonates (BPs) are widely used in the treatment of several bone diseases, such as osteoporosis and cancers that have metastasized to bone, by…”
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Osteogenic differentiation of periodontal ligament fibroblasts inhibits osteoclast formation by Prins, Caya M., Ceylan, Merve, Hogervorst, Jolanda M.A., Jansen, Ineke D.C., Schimmel, Irene M., Schoenmaker, Ton, de Vries, Teun J.

“…One of the deficits of knowledge on bone remodelling, is to what extent cells that are driven towards osteogenic differentiation can contribute to osteoclast…”
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Increased Bone Resorption during Lactation in Pycnodysostosis by Jansen, Ineke D C, Papapoulos, Socrates E, Bravenboer, Nathalie, de Vries, Teun J, Appelman-Dijkstra, Natasha M

“…Pycnodysostosis, a rare autosomal recessive skeletal dysplasia, is caused by a deficiency of cathepsin K. Patients have impaired bone resorption in the…”
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LAMP-2 Is Involved in Surface Expression of RANKL of Osteoblasts In Vitro by Jansen, Ineke D C, Tigchelaar-Gutter, Wikky, Hogervorst, Jolanda M A, de Vries, Teun J, Saftig, Paul, Everts, Vincent

“…Lysosome associated membrane proteins (LAMPs) are involved in several processes, among which is fusion of lysosomes with phagosomes. For the formation of…”
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Green Robusta Coffee Bean Extract (GRCBE) inhibits bone loss in wistar rat models of Lps P. gingivalis and NiTi wire-induced experimental periodontitis by Rachmawati, Dessy, Ermawati, Tantin, Rahmatillah, Nanda Innayatur, Meylina, Nurwandani, Safitri, Novia Yolanda, Sutjiati, Rina, Jansen, Ineke D.C.

“…•There is synergy between metal exposure and endotoxins characterized by the production of pro-inflammatory cytokines in vivo.•GRCBE has a potential capacity…”
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Gingival fibroblasts produce paracrine signals that affect osteoclastogenesis in vitro by Novello, Solen, Schoenmaker, Ton, de Vries, Teun J., Doulabi, Behrouz Zandieh, Bakker, Astrid D., Laine, Marja L., Jansen, Ineke D.C.

“…In periodontitis, gingival fibroblasts (GF) appear to produce a multitude of paracrine factors. However, the influence of GF-derived soluble factors on…”
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Increase in the Number of Bone Marrow Osteoclast Precursors at Different Skeletal Sites, Particularly in Long Bone and Jaw Marrow in Mice Lacking IL-1RA by Ascone, Giuliana, Cao, Yixuan, Jansen, Ineke D C, Di Ceglie, Irene, van den Bosch, Martijn H J, Blom, Arjen B, van Lent, Peter L E M, Everts, Vincent, de Vries, Teun J

“…Recently, it was shown that interleukin-1β (IL-1β) has diverse stimulatory effects on different murine long bone marrow osteoclast precursors (OCPs) in vitro…”
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Real-time quantification of osteoclastic resorptive activity by electric cell-substrate impedance sensing by Jansen, Ineke D.C., van Velzen, Thijs, de Vries, Teun J., Szulcek, Robert, van Loon, Jack J. W. A.

“…In several diseases, bone resorption by osteoclasts is dysregulated. Thus far, no simple technique for real-time measurement of resorption is available. Here,…”
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Ae2a,b-Deficient mice exhibit osteopetrosis of long bones but not of calvaria by Jansen, Ineke D.C, Mardones, Pablo, Lecanda, Fernando, de Vries, Teun J, Recalde, Sergio, Hoeben, Kees A, Schoenmaker, Ton, Ravesloot, Jan-Hindrik, van Borren, Marcel M.G.J, van Eijden, Theo M, Bronckers, Antonius L.J.J, Kellokumpu, Sakari, Medina, Juan F, Everts, Vincent, Oude Elferink, Ronald P.J

“…Extracellular acidification by osteoclasts is essential to bone resorption. During proton pumping, intracellular pH (pHi) is thought to be kept at a…”
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Mechanisms of bone resorption by Everts, Vincent, Jansen, Ineke D.C., de Vries, Teun J.

“…Resorption of mineralized tissues like bone is accomplished by a unique cell type: the osteoclast. This multinucleated cell has the capacity to dissolve the…”
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Effects of L‐PRF and A‐PRF+ on periodontal fibroblasts in in vitro wound healing experiments by Pitzurra, Luciano, Jansen, Ineke D. C., Vries, Teun J., Hoogenkamp, Michel A., Loos, Bruno G.

“…Objective To determine whether leukocyte‐platelet‐rich fibrin (L‐PRF) and advanced platelet‐rich fibrin (A‐PRF+) differ in their in vitro capacity to induce…”
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TNF‐α has both stimulatory and inhibitory effects on mouse monocyte‐derived osteoclastogenesis by Cao, Yixuan, Jansen, Ineke D.C., Sprangers, Sara, de Vries, Teun J., Everts, Vincent

“…Phenotypically different osteoclasts may be generated from different subsets of precursors. To what extent the formation of these osteoclasts is influenced or…”
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The Alkyne Moiety as a Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K by Mons, Elma, Jansen, Ineke D. C, Loboda, Jure, van Doodewaerd, Bjorn R, Hermans, Jill, Verdoes, Martijn, van Boeckel, Constant A. A, van Veelen, Peter A, Turk, Boris, Turk, Dusan, Ovaa, Huib

“…Irreversible covalent inhibitors can have a beneficial pharmacokinetic/pharmacodynamics profile but are still often avoided due to the risk of indiscriminate…”
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What Are the Peripheral Blood Determinants for Increased Osteoclast Formation in the Various Inflammatory Diseases Associated With Bone Loss? by de Vries, Teun J, El Bakkali, Ismail, Kamradt, Thomas, Schett, Georg, Jansen, Ineke D C, D'Amelio, Patrizia

“…Local priming of osteoclast precursors (OCp) has long been considered the main and obvious pathway that takes place in the human body, where local bone lining…”
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IL‐1β differently stimulates proliferation and multinucleation of distinct mouse bone marrow osteoclast precursor subsets by Cao, Yixuan, Jansen, Ineke D. C., Sprangers, Sara, Stap, Jan, Leenen, Pieter J.M., Everts, Vincent, Vries, Teun J.

“…IL‐1β has diverse stimulatory effects on different bone marrow osteoclast precursors. Osteoclasts are bone‐resorbing cells and targets for treating bone…”
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IgA Immune Complexes Induce Osteoclast-Mediated Bone Resorption by Breedveld, Annelot C., van Gool, Melissa M. J., van Delft, Myrthe A. M., van der Laken, Conny J., de Vries, Teun J., Jansen, Ineke D. C., van Egmond, Marjolein

“…ObjectiveAutoantibodies are detected in most patients with rheumatoid arthritis (RA) and can be of the IgM, IgG or IgA subclass. Correlations between IgA…”
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Osteoclast Fusion and Fission by Jansen, Ineke D. C., Vermeer, Jenny A. F., Bloemen, Veerle, Stap, Jan, Everts, Vincent

“…Osteoclasts are specialized multinucleated cells with the unique capacity to resorb bone. Despite insight into the various steps of the interaction of…”
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Chronic Exposure of Gingival Fibroblasts to TLR2 or TLR4 Agonist Inhibits Osteoclastogenesis but Does Not Affect Osteogenesis by Karlis, Gerasimos D, Schöningh, Emily, Jansen, Ineke D C, Schoenmaker, Ton, Hogervorst, Jolanda M A, van Veen, Henk A, Moonen, Carolyn G J, Łagosz-Ćwik, Katarzyna B, Forouzanfar, Tim, de Vries, Teun J

“…Chronic exposure to periodontopathogenic bacteria such as and the products of these bacteria that interact with the cells of the tooth surrounding tissues can…”
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Conditional mouse models support the role of SLC39A14 (ZIP14) in Hyperostosis Cranialis Interna and in bone homeostasis by Hendrickx, Gretl, Borra, Vere M, Steenackers, Ellen, Yorgan, Timur A, Hermans, Christophe, Boudin, Eveline, Waterval, Jérôme J, Jansen, Ineke D C, Aydemir, Tolunay Beker, Kamerling, Niels, Behets, Geert J, Plumeyer, Christine, D'Haese, Patrick C, Busse, Björn, Everts, Vincent, Lammens, Martin, Mortier, Geert, Cousins, Robert J, Schinke, Thorsten, Stokroos, Robert J, Manni, Johannes J, Van Hul, Wim

“…Hyperostosis Cranialis Interna (HCI) is a rare bone disorder characterized by progressive intracranial bone overgrowth at the skull. Here we identified by…”
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