Search Results - "Jansen, Hanne"
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Human Thymic CD10 + PD-1 + Intraepithelial Lymphocyte Precursors Acquire Interleukin-15 Responsiveness at the CD1a - CD95 + CD28 - CCR7 - Developmental Stage
Published in International journal of molecular sciences (20-11-2020)“…Human thymic CD8αα CD10 PD-1 αβ T cells selected through early agonist selection have been proposed as the putative thymic precursors of the human CD8αα…”
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The Wiskott-Aldrich syndrome protein is required for positive selection during T-cell lineage differentiation
Published in Frontiers in immunology (07-06-2023)“…The Wiskott-Aldrich syndrome (WAS) is an X-linked primary immune deficiency caused by a mutation in the WAS gene. This leads to altered or absent WAS protein…”
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In vitro OP9-DL1 co-culture and subsequent maturation in the presence of IL-21 generates tumor antigen-specific T cells with a favorable less-differentiated phenotype and enhanced functionality
Published in Oncoimmunology (01-01-2021)“…T cell receptor (TCR)-redirected T cells target intracellular antigens such as Wilms' tumor 1 (WT1), a tumor-associated antigen overexpressed in several…”
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I'm a translator and I'm proud: how literary translators view authors and authorship
Published in Perspectives, studies in translatology (03-09-2019)“…This article investigates the relationship of literary translators with 'their' authors and with the source text. The issue has been dealt with from different…”
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Bibliografia/Bibliography
Published in Globe (18-12-2023)“…Bibliografia/Bibliography…”
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Single-cell profiling identifies a novel human polyclonal unconventional T cell lineage
Published in The Journal of experimental medicine (05-06-2023)“…In the human thymus, a CD10+ PD-1+ TCRαβ+ differentiation pathway diverges from the conventional single positive T cell lineages at the early double-positive…”
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ThymoSpheres culture: A model to study human polyclonal unconventional T cells
Published in European journal of immunology (09-09-2024)“…In vitro cultures remain crucial for studying the fundamental mechanisms of human T-cell development. Here, we introduce a novel in vitro cultivation system…”
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Small-scale manufacturing of neoantigen-encoding messenger RNA for early-phase clinical trials
Published in Cytotherapy (Oxford, England) (01-02-2022)“…Messenger RNA (mRNA) has become a promising tool in therapeutic cancer vaccine strategies. Owing to its flexible design and rapid production, mRNA is an…”
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Knocking Out CD70 Rescues CD70-Specific NanoCAR T Cells from Antigen-Induced Exhaustion
Published in Cancer immunology research (03-09-2024)“…CD70 is an attractive target for chimeric antigen receptor (CAR) T-cell therapy for the treatment of both solid and liquid malignancies. However, the…”
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Introduction: voice, ethics and translation
Published in Perspectives, studies in translatology (03-09-2019)“…Although previous research on ethics demonstrates growing awareness that many agents or subjectivities besides translators and interpreters are involved in…”
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An integrated translational analysis summary: Prediction of HERG, isolated wedge preparation, anaesthetized guinea pig and dog towards phase I clinical data for drugs with different QT/TdP risk categories
Published in Journal of pharmacological and toxicological methods (01-09-2019)Get full text
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Neoantigen-targeted dendritic cell vaccination in lung cancer patients induces long-lived T cells exhibiting the full differentiation spectrum
Published in Cell reports. Medicine (21-05-2024)“…Non-small cell lung cancer (NSCLC) is known for high relapse rates despite resection in early stages. Here, we present the results of a phase I clinical trial…”
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