Search Results - "Jansen, Erik A.M."

Germline MBD4 deficiency causes a multi-tumor predisposition syndrome by Palles, Claire, West, Hannah D., Chew, Edward, Galavotti, Sara, Flensburg, Christoffer, Grolleman, Judith E., Jansen, Erik A.M., Curley, Helen, Chegwidden, Laura, Arbe-Barnes, Edward H., Lander, Nicola, Truscott, Rebekah, Pagan, Judith, Bajel, Ashish, Sherwood, Kitty, Martin, Lynn, Thomas, Huw, Georgiou, Demetra, Fostira, Florentia, Goldberg, Yael, Adams, David J., van der Biezen, Simone A.M., Christie, Michael, Clendenning, Mark, Thomas, Laura E., Deltas, Constantinos, Dimovski, Aleksandar J., Dymerska, Dagmara, Lubinski, Jan, Mahmood, Khalid, van der Post, Rachel S., Sanders, Mathijs, Weitz, Jürgen, Taylor, Jenny C., Turnbull, Clare, Vreede, Lilian, van Wezel, Tom, Whalley, Celina, Arnedo-Pac, Claudia, Caravagna, Giulio, Cross, William, Chubb, Daniel, Frangou, Anna, Gruber, Andreas J., Kinnersley, Ben, Noyvert, Boris, Church, David, Graham, Trevor, Houlston, Richard, Lopez-Bigas, Nuria, Sottoriva, Andrea, Wedge, David, Jenkins, Mark A., Kuiper, Roland P., Roberts, Andrew W., Cheadle, Jeremy P., Ligtenberg, Marjolijn J.L., Hoogerbrugge, Nicoline, Koelzer, Viktor H., Rivas, Andres Dacal, Winship, Ingrid M., Ponte, Clara Ruiz, Buchanan, Daniel D., Power, Derek G., Green, Andrew, Tomlinson, Ian P.M., Sampson, Julian R., Majewski, Ian J., de Voer, Richarda M.

“…We report an autosomal recessive, multi-organ tumor predisposition syndrome, caused by bi-allelic loss-of-function germline variants in the base excision…”
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Clinical Validity of Tumor-Informed Circulating Tumor DNA Analysis in Patients Undergoing Surgery of Colorectal Metastases by Hofste, Lisa S.M., Geerlings, Maartje J., Kamping, Eveline J., Kouwenhoven, Nadine D.H., von Rhein, Daniel, Jansen, Erik A.M., Garms, Linda M., Nagtegaal, Iris D., van der Post, Rachel S., de Wilt, Johannes H.W., Klarenbeek, Bastiaan R., Ligtenberg, Marjolijn J.L.

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Evaluation of a Hybrid Capture–Based Pan-Cancer Panel for Analysis of Treatment Stratifying Oncogenic Aberrations and Processes by Kroeze, Leonie I., de Voer, Richarda M., Kamping, Eveline J., von Rhein, Daniel, Jansen, Erik A.M., Hermsen, Mandy J.W., Barberis, Massimo C.P., Botling, Johan, Garrido-Martin, Eva M., Haller, Florian, Lacroix, Ludovic, Maes, Brigitte, Merkelbach-Bruse, Sabine, Pestinger, Valerie, Pfarr, Nicole, Stenzinger, Albrecht, van den Heuvel, Michel M., Grünberg, Katrien, Ligtenberg, Marjolijn J.L.

“…Stratification of patients for targeted and immune-based therapies requires extensive genomic profiling that enables sensitive detection of clinically relevant…”
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Monoallelic NTHL1 Loss-of-Function Variants and Risk of Polyposis and Colorectal Cancer by Elsayed, Fadwa A., Grolleman, Judith E., Ragunathan, Abiramy, Boot, Arnoud, Stojovska, Marija Staninova, Mahmood, Khalid, Clendenning, Mark, de Miranda, Noel, Dymerska, Dagmara, Egmond, Demi van, Gallinger, Steven, Georgeson, Peter, Hoogerbrugge, Nicoline, Hopper, John L., Jansen, Erik A.M., Jenkins, Mark A., Joo, Jihoon E., Kuiper, Roland P., Ligtenberg, Marjolijn J.L., Lubinski, Jan, Macrae, Finlay A., Morreau, Hans, Newcomb, Polly, Nielsen, Maartje, Palles, Claire, Park, Daniel J., Pope, Bernard J., Rosty, Christophe, Ruiz Ponte, Clara, Schackert, Hans K., Sijmons, Rolf H., Tomlinson, Ian P., Tops, Carli M.J., Vreede, Lilian, Walker, Romy, Win, Aung K., Buchanan, Daniel D., van Wezel, Tom, de Voer, Richarda M.

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Clinical Validity of Tumor-Informed Circulating Tumor DNA Analysis in Patients Undergoing Surgery of Colorectal Metastases by Hofste, Lisa S.M., Geerlings, Maartje J., Kamping, Eveline J., Kouwenhoven, Nadine D.H., von Rhein, Daniel, Jansen, Erik A.M., Garms, Linda M., Nagtegaal, Iris D., van der Post, Rachel S., de Wilt, Johannes H.W., Klarenbeek, Bastiaan R., Ligtenberg, Marjolijn J.L.

“…Accurate biomarkers to monitor tumor load and response in metastatic colorectal cancer patients undergoing surgery could optimize treatment regimens. This…”
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Mutational signature analysis in non-small cell lung cancer patients with a high tumor mutational burden by van den Heuvel, Guus R M, Kroeze, Leonie I, Ligtenberg, Marjolijn J L, Grünberg, Katrien, Jansen, Erik A M, von Rhein, Daniel, de Voer, Richarda M, van den Heuvel, Michel M

“…Lung cancer is the leading cause of cancer death worldwide. With the growing number of targeted therapies and the introduction of immuno-oncology (IO),…”
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Comprehensive routine diagnostic screening to identify predictive mutations, gene amplifications, and microsatellite instability in FFPE tumor material by Steeghs, Elisabeth M P, Kroeze, Leonie I, Tops, Bastiaan B J, van Kempen, Leon C, Ter Elst, Arja, Kastner-van Raaij, Annemiek W M, Hendriks-Cornelissen, Sandra J B, Hermsen, Mandy J W, Jansen, Erik A M, Nederlof, Petra M, Schuuring, Ed, Ligtenberg, Marjolijn J L, Eijkelenboom, Astrid

“…Sensitive and reliable molecular diagnostics is needed to guide therapeutic decisions for cancer patients. Although less material becomes available for…”
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Identification of Fusion Genes and Targets for Genetically Matched Therapies in a Large Cohort of Salivary Gland Cancer Patients by Lassche, Gerben, van Helvert, Sjoerd, Eijkelenboom, Astrid, Tjan, Martijn J. H., Jansen, Erik A. M., van Cleef, Patricia H. J., Verhaegh, Gerald W., Kamping, Eveline J., Grünberg, Katrien, van Engen-van Grunsven, Adriana C. H., Ligtenberg, Marjolijn J. L., van Herpen, Carla M. L.

“…Introduction: Salivary gland cancer (SGC) is a rare cancer for which systemic treatment options are limited. Therefore, it is important to characterize its…”
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Comprehensive clinicopathological and genomic profiling of gallbladder cancer reveals actionable targets in half of patients by de Bitter, Tessa J. J., de Reuver, Philip R., de Savornin Lohman, Elise A. J., Kroeze, Leonie I., Vink-Börger, Marianne E., van Vliet, Shannon, Simmer, Femke, von Rhein, Daniel, Jansen, Erik A. M., Verheij, Joanne, van Herpen, Carla M. L., Nagtegaal, Iris D., Ligtenberg, Marjolijn J. L., van der Post, Rachel S.

“…Gallbladder cancer (GBC) is a rare, highly aggressive malignancy with a 5-year survival rate of 5–10% in advanced cases, highlighting the need for more…”
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Unraveling Neuroendocrine Gallbladder Cancer: Comprehensive Clinicopathologic and Molecular Characterization by de Bitter, Tessa J J, Kroeze, Leonie I, de Reuver, Philip R, van Vliet, Shannon, Vink-Börger, Elisa, von Rhein, Daniel, Jansen, Erik A M, Nagtegaal, Iris D, Ligtenberg, Marjolijn J L, van der Post, Rachel S

“…Neuroendocrine carcinomas and mixed neuroendocrine non-neuroendocrine neoplasms of the gallbladder (NE GBC) are rare and highly aggressive entities. The cell…”
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