Search Results - "Jansen, Daniel J"

Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds by Horton, John R, Liu, Xu, Gale, Molly, Wu, Lizhen, Shanks, John R, Zhang, Xing, Webber, Philip J, Bell, Joshua S K, Kales, Stephen C, Mott, Bryan T, Rai, Ganesha, Jansen, Daniel J, Henderson, Mark J, Urban, Daniel J, Hall, Matthew D, Simeonov, Anton, Maloney, David J, Johns, Margaret A, Fu, Haian, Jadhav, Ajit, Vertino, Paula M, Yan, Qin, Cheng, Xiaodong

“…The KDM5/JARID1 family of Fe(II)- and α-ketoglutarate-dependent demethylases removes methyl groups from methylated lysine 4 of histone H3. Accumulating…”
Get more information

Structure-Based Engineering of Irreversible Inhibitors against Histone Lysine Demethylase KDM5A by Horton, John R, Woodcock, Clayton B, Chen, Qin, Liu, Xu, Zhang, Xing, Shanks, John, Rai, Ganesha, Mott, Bryan T, Jansen, Daniel J, Kales, Stephen C, Henderson, Mark J, Cyr, Matthew, Pohida, Katherine, Hu, Xin, Shah, Pranav, Xu, Xin, Jadhav, Ajit, Maloney, David J, Hall, Matthew D, Simeonov, Anton, Fu, Haian, Vertino, Paula M, Cheng, Xiaodong

“…The active sites of hundreds of human α-ketoglutarate (αKG) and Fe­(II)-dependent dioxygenases are exceedingly well preserved, which challenges the design of…”
Get full text

KDM5 histone demethylases repress immune response via suppression of STING by Wu, Lizhen, Cao, Jian, Cai, Wesley L, Lang, Sabine M, Horton, John R, Jansen, Daniel J, Liu, Zongzhi Z, Chen, Jocelyn F, Zhang, Meiling, Mott, Bryan T, Pohida, Katherine, Rai, Ganesha, Kales, Stephen C, Henderson, Mark J, Hu, Xin, Jadhav, Ajit, Maloney, David J, Simeonov, Anton, Zhu, Shu, Iwasaki, Akiko, Hall, Matthew D, Cheng, Xiaodong, Shadel, Gerald S, Yan, Qin

“…Cyclic GMP-AMP (cGAMP) synthase (cGAS) stimulator of interferon genes (STING) senses pathogen-derived or abnormal self-DNA in the cytosol and triggers an…”
Get full text

Synthesis and Sulfur Electrophilicity of the Nuphar Thiaspirane Pharmacophore by Tada, Norihiro, Jansen, Daniel J, Mower, Matthew P, Blewett, Megan M, Umotoy, Jeffrey C, Cravatt, Benjamin F, Wolan, Dennis W, Shenvi, Ryan A

“…We describe a general method to synthesize the iminium tetrahydrothiophene embedded in the dimeric Nuphar alkaloids. In contrast to prior studies, the sulfur…”
Get full text

Synthesis of (−)-Neothiobinupharidine by Jansen, Daniel J, Shenvi, Ryan A

“…An eight step, asymmetric synthesis of a dimeric thiaspirane nuphar alkaloid from 3-methyl-2-cyclo-pentenone is reported. The brevity of the route relies on a…”
Get full text

KDM5B Promotes Drug Resistance by Regulating Melanoma-Propagating Cell Subpopulations by Liu, Xiaoni, Zhang, Shang-Min, McGeary, Meaghan K, Krykbaeva, Irina, Lai, Ling, Jansen, Daniel J, Kales, Stephen C, Simeonov, Anton, Hall, Matthew D, Kelly, Daniel P, Bosenberg, Marcus W, Yan, Qin

“…Tumor heterogeneity is a major challenge for cancer treatment, especially due to the presence of various subpopulations with stem cell or progenitor cell…”
Get full text

Synthesis of medicinally relevant terpenes: reducing the cost and time of drug discovery by Jansen, Daniel J, Shenvi, Ryan A

“…Terpenoids constitute a significant fraction of molecules produced by living organisms that have found use in medicine and other industries. Problems…”
Get more information

Intramolecular azide-alkyne [3 + 2] cycloaddition: versatile route to new heterocyclic structural scaffolds by Li, Rongti, Jansen, Daniel J, Datta, Apurba

“…Investigating the relatively unexplored intramolecular version of the azide-alkyne [3 + 2] cycloaddition, the present studies demonstrate the utility of the…”
Get more information

A Stereoselective Hydroamination Transform To Access Polysubstituted Indolizidines by Pronin, Sergey V, Tabor, M. Greg, Jansen, Daniel J, Shenvi, Ryan A

“…Stereoselective, intramolecular, formal hydroamination of dienamines via directed hydroboration is reported. Four stereocenters are set in the process. Natural…”
Get full text

Insights into the Action of Inhibitor Enantiomers against Histone Lysine Demethylase 5A by Horton, John R, Liu, Xu, Wu, Lizhen, Zhang, Kai, Shanks, John, Zhang, Xing, Rai, Ganesha, Mott, Bryan T, Jansen, Daniel J, Kales, Stephen C, Henderson, Mark J, Pohida, Katherine, Fang, Yuhong, Hu, Xin, Jadhav, Ajit, Maloney, David J, Hall, Matthew D, Simeonov, Anton, Fu, Haian, Vertino, Paula M, Yan, Qin, Cheng, Xiaodong

“…Isomers of chiral drugs can exhibit marked differences in biological activities. We studied the binding and inhibitory activities of 12 compounds against…”
Get full text

Small Molecule Inhibitors of Activation-Induced Deaminase Decrease Class Switch Recombination in B Cells by Alvarez-Gonzalez, Juan, Yasgar, Adam, Maul, Robert W, Rieffer, Amanda E, Crawford, Daniel J, Salamango, Daniel J, Dorjsuren, Dorjbal, Zakharov, Alexey V, Jansen, Daniel J, Rai, Ganesha, Marugan, Juan, Simeonov, Anton, Harris, Reuben S, Kohli, Rahul M, Gearhart, Patricia J

“…Activation-induced deaminase (AID) not only mutates DNA within the immunoglobulin loci to generate antibody diversity, but it also promotes development of B…”
Get full text

Validation of an instrument for mathematics enhancement teaching efficacy of Pacific Northwest agricultural educators by Jansen, Daniel J

“…Teacher efficacy continues to be an important area of study in educational research. This study tested an instrument designed to assess the perceived efficacy…”
Get full text

Validation of an instrument for mathematics enhancement teaching efficacy of Pacific Northwest agricultural educators by Jansen, Daniel J

“…Teacher efficacy continues to be an important area of study in educational research. This study tested an instrument designed to assess the perceived efficacy…”
Get full text

Synthesis of saligenin analogues of phenylpropanolamines by Dekker, Jakob J., Greeff, daniël F., Jansen, Arnold A., Mostert, Hendrik F. & Venter, Daniel P.

Get full text