Search Results - "Janse, Chris J."

Common PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection by Ma, Shang, Cahalan, Stuart, LaMonte, Gregory, Grubaugh, Nathan D., Zeng, Weizheng, Murthy, Swetha E., Paytas, Emma, Gamini, Ramya, Lukacs, Viktor, Whitwam, Tess, Loud, Meaghan, Lohia, Rakhee, Berry, Laurence, Khan, Shahid M., Janse, Chris J., Bandell, Michael, Schmedt, Christian, Wengelnik, Kai, Su, Andrew I., Honore, Eric, Winzeler, Elizabeth A., Andersen, Kristian G., Patapoutian, Ardem

“…Hereditary xerocytosis is thought to be a rare genetic condition characterized by red blood cell (RBC) dehydration with mild hemolysis. RBC dehydration is…”
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High-efficiency transfection and drug selection of genetically transformed blood stages of the rodent malaria parasite Plasmodium berghei by Janse, Chris J, Ramesar, Jai, Waters, Andrew P

“…This protocol describes a method of genetic transformation for the rodent malaria parasite Plasmodium berghei with a high transfection efficiency of…”
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Neutralization of the Plasmodium-encoded MIF ortholog confers protective immunity against malaria infection by Baeza Garcia, Alvaro, Siu, Edwin, Sun, Tiffany, Exler, Valerie, Brito, Luis, Hekele, Armin, Otten, Gib, Augustijn, Kevin, Janse, Chris J., Ulmer, Jeffrey B., Bernhagen, Jürgen, Fikrig, Erol, Geall, Andrew, Bucala, Richard

“…Plasmodium species produce an ortholog of the cytokine macrophage migration inhibitory factor, PMIF, which modulates the host inflammatory response to malaria…”
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A Plasmodium phospholipase is involved in disruption of the liver stage parasitophorous vacuole membrane by Burda, Paul-Christian, Roelli, Matthias A, Schaffner, Marco, Khan, Shahid M, Janse, Chris J, Heussler, Volker T

“…The coordinated exit of intracellular pathogens from host cells is a process critical to the success and spread of an infection. While phospholipases have been…”
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CD8+ T Cells Induce Fatal Brainstem Pathology during Cerebral Malaria via Luminal Antigen-Specific Engagement of Brain Vasculature by Swanson, 2nd, Phillip A, Hart, Geoffrey T, Russo, Matthew V, Nayak, Debasis, Yazew, Takele, Peña, Mirna, Khan, Shahid M, Janse, Chris J, Pierce, Susan K, McGavern, Dorian B

“…Cerebral malaria (CM) is a severe complication of Plasmodium falciparum infection that results in thousands of deaths each year, mostly in African children…”
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Universal features of post-transcriptional gene regulation are critical for Plasmodium zygote development by Mair, Gunnar R, Lasonder, Edwin, Garver, Lindsey S, Franke-Fayard, Blandine M D, Carret, Céline K, Wiegant, Joop C A G, Dirks, Roeland W, Dimopoulos, George, Janse, Chris J, Waters, Andrew P

“…A universal feature of metazoan sexual development is the generation of oocyte P granules that withhold certain mRNA species from translation to provide coding…”
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Artemisinin exposure at the ring or trophozoite stage impacts Plasmodium falciparum sexual conversion differently by Portugaliza, Harvie P, Miyazaki, Shinya, Geurten, Fiona Ja, Pell, Christopher, Rosanas-Urgell, Anna, Janse, Chris J, Cortés, Alfred

“…Malaria transmission is dependent on the formation of gametocytes in the human blood. The sexual conversion rate, the proportion of asexual parasites that…”
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Transcriptome analysis of Plasmodium berghei during exo-erythrocytic development by Caldelari, Reto, Dogga, Sunil, Schmid, Marc W, Franke-Fayard, Blandine, Janse, Chris J, Soldati-Favre, Dominique, Heussler, Volker

“…The complex life cycle of malaria parasites requires well-orchestrated stage specific gene expression. In the vertebrate host the parasites grow and multiply…”
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Prime and target immunization protects against liver-stage malaria in mice by Gola, Anita, Silman, Daniel, Walters, Adam A, Sridhar, Saranya, Uderhardt, Stefan, Salman, Ahmed M, Halbroth, Benedict R, Bellamy, Duncan, Bowyer, Georgina, Powlson, Jonathan, Baker, Megan, Venkatraman, Navin, Poulton, Ian, Berrie, Eleanor, Roberts, Rachel, Lawrie, Alison M, Angus, Brian, Khan, Shahid M, Janse, Chris J, Ewer, Katie J, Germain, Ronald N, Spencer, Alexandra J, Hill, Adrian V S

“…Despite recent advances in treatment and vector control, malaria is still a leading cause of death, emphasizing the need for an effective vaccine. The malaria…”
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Genome-wide RIP-Chip analysis of translational repressor-bound mRNAs in the Plasmodium gametocyte by Guerreiro, Ana, Deligianni, Elena, Santos, Jorge M, Silva, Patricia A G C, Louis, Christos, Pain, Arnab, Janse, Chris J, Franke-Fayard, Blandine, Carret, Celine K, Siden-Kiamos, Inga, Mair, Gunnar R

“…Following fertilization, the early proteomes of metazoans are defined by the translation of stored but repressed transcripts; further embryonic development…”
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Malaria parasite evades mosquito immunity by glutaminyl cyclase-mediated posttranslational protein modification by Kolli, Surendra Kumar, Molina-Cruz, Alvaro, Araki, Tamasa, Geurten, Fiona J A, Ramesar, Jai, Chevalley-Maurel, Severine, Kroeze, Hans J, Bezemer, Sascha, de Korne, Clarize, Withers, Roxanne, Raytselis, Nadia, El Hebieshy, Angela F, Kim, Robbert Q, Child, Matthew A, Kakuta, Soichiro, Hisaeda, Hajime, Kobayashi, Hirotaka, Annoura, Takeshi, Hensbergen, Paul J, Franke-Fayard, Blandine M, Barillas-Mury, Carolina, Scheeren, Ferenc A, Janse, Chris J

“…Glutaminyl cyclase (QC) modifies N-terminal glutamine or glutamic acid residues of target proteins into cyclic pyroglutamic acid (pGlu). Here, we report the…”
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Control of Disease Tolerance to Malaria by Nitric Oxide and Carbon Monoxide by Jeney, Viktória, Ramos, Susana, Bergman, Marie-Louise, Bechmann, Ingo, Tischer, Jasmin, Ferreira, Ana, Oliveira-Marques, Virginia, Janse, Chris J., Rebelo, Sofia, Cardoso, Silvia, Soares, Miguel P.

“…Nitric oxide (NO) and carbon monoxide (CO) are gasotransmitters that suppress the development of severe forms of malaria associated with Plasmodium infection…”
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Sequestration and tissue accumulation of human malaria parasites: can we learn anything from rodent models of malaria? by Franke-Fayard, Blandine, Fonager, Jannik, Braks, Anneke, Khan, Shahid M, Janse, Chris J

“…The sequestration of Plasmodium falciparum-infected red blood cells (irbcs) in the microvasculature of organs is associated with severe disease;…”
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Exploring in vitro expression and immune potency in mice using mRNA encoding the Plasmodium falciparum malaria antigen, CelTOS by Waghela, Ishita N, Mallory, Katherine L, Taylor, Justin A, Schneider, Cosette G, Savransky, Tatyana, Janse, Chris J, Lin, Paulo J C, Tam, Ying K, Weissman, Drew, Angov, Evelina

“…The secreted malarial protein, Cell-Traversal protein for Ookinetes and Sporozoites (CelTOS), is highly conserved among species, and plays a role in the…”
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Three members of the 6-cys protein family of Plasmodium play a role in gamete fertility by van Dijk, Melissa R, van Schaijk, Ben C L, Khan, Shahid M, van Dooren, Maaike W, Ramesar, Jai, Kaczanowski, Szymon, van Gemert, Geert-Jan, Kroeze, Hans, Stunnenberg, Hendrik G, Eling, Wijnand M, Sauerwein, Robert W, Waters, Andrew P, Janse, Chris J

“…The process of fertilization is critically dependent on the mutual recognition of gametes and in Plasmodium, the male gamete surface protein P48/45 is vital to…”
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Screening of viral-vectored P. falciparum pre-erythrocytic candidate vaccine antigens using chimeric rodent parasites by Kolli, Surendra Kumar, Salman, Ahmed M, Ramesar, Jai, Chevalley-Maurel, Severine, Kroeze, Hans, Geurten, Fiona G A, Miyazaki, Shinya, Mukhopadhyay, Ekta, Marin-Mogollon, Catherin, Franke-Fayard, Blandine, Hill, Adrian V S, Janse, Chris J

“…To screen for additional vaccine candidate antigens of Plasmodium pre-erythrocytic stages, fourteen P. falciparum proteins were selected based on expression in…”
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The machinery underlying malaria parasite virulence is conserved between rodent and human malaria parasites by De Niz, Mariana, Ullrich, Ann-Katrin, Heiber, Arlett, Blancke Soares, Alexandra, Pick, Christian, Lyck, Ruth, Keller, Derya, Kaiser, Gesine, Prado, Monica, Flemming, Sven, del Portillo, Hernando, Janse, Chris J., Heussler, Volker, Spielmann, Tobias

“…Sequestration of red blood cells infected with the human malaria parasite Plasmodium falciparum in organs such as the brain is considered important for…”
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Experimental vaccination by single dose sporozoite injection of blood-stage attenuated malaria parasites by Sattler, Julia M, Keiber, Lukas, Abdelrahim, Aiman, Zheng, Xinyu, Jäcklin, Martin, Zechel, Luisa, Moreau, Catherine A, Steinbrück, Smilla, Fischer, Manuel, Janse, Chris J, Hoffmann, Angelika, Hentzschel, Franziska, Frischknecht, Friedrich

“…Malaria vaccination approaches using live Plasmodium parasites are currently explored, with either attenuated mosquito-derived sporozoites or attenuated…”
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Identification of a transcription factor in the mosquito-invasive stage of malaria parasites by Yuda, Masao, Iwanaga, Shiroh, Shigenobu, Shuji, Mair, Gunnar R, Janse, Chris J, Waters, Andrew P, Kato, Tomomi, Kaneko, Izumi

“…Gene expression in Plasmodium parasites undergoes significant changes in each developmental stage, but the transcription factors (TFs) regulating these changes…”
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A universal vaccine candidate against Plasmodium vivax malaria confers protective immunity against the three PvCSP alleles by Gimenez, Alba Marina, Salman, Ahmed M., Marques, Rodolfo F., López-Camacho, César, Harrison, Kate, Kim, Young Chan, Janse, Chris J., Soares, Irene S., Reyes-Sandoval, Arturo

“…Malaria is a highly prevalent parasitic disease in regions with tropical and subtropical climates worldwide. Among the species of Plasmodium causing human…”
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