Search Results - "Janse, C J"

The dynamics of interactions between Plasmodium and the mosquito: a study of the infectivity of Plasmodium berghei and Plasmodium gallinaceum, and their transmission by Anopheles stephensi, Anopheles gambiae and Aedes aegypti by Alavi, Y., Arai, M., Mendoza, J., Tufet-Bayona, M., Sinha, R., Fowler, K., Billker, O., Franke-Fayard, B., Janse, C.J., Waters, A., Sinden, R.E.

“…Knowledge of parasite–mosquito interactions is essential to develop strategies that will reduce malaria transmission through the mosquito vector. In this study…”
Get full text

Simple and sensitive antimalarial drug screening in vitro and in vivo using transgenic luciferase expressing Plasmodium berghei parasites by Franke-Fayard, B., Djokovic, D., Dooren, M.W., Ramesar, J., Waters, A.P., Falade, M.O., Kranendonk, M., Martinelli, A., Cravo, P., Janse, C.J.

“…We report two improved assays for in vitro and in vivo screening of chemicals with potential anti-malarial activity against the blood stages of the rodent…”
Get full text

Stable transfection of malaria parasite blood stages by Dijk, M.R. van (University of Leiden, Leiden, Netherlands.), Waters, A.P, Janse, C.J

“…Genetic manipulation of malaria parasites would revolutionize the study of this group of pathogens and have implications for vaccine and drug development. This…”
Get full text

Comparative genomics in Plasmodium: a tool for the identification of genes and functional analysis by Thompson, J., Janse, C.J., Waters, A.P.

“…Comparative genomics allows inferences to be drawn about the coding potential of related genomes, and the evolutionary forces that have influenced genome…”
Get full text

THE DEVELOPMENT OF GENETIC TOOLS FOR DISSECTING THE BIOLOGY OF MALARIA PARASITES by de Koning-Ward, Tania F, Janse, Chris J, Waters, Andrew P

“…Plasmodium parasites are haploid unicellular organisms that cause malaria. In the last decade, transfection systems have been developed for both human and…”
Get full text

Transfection of Malaria Parasites by Waters, A.P., Thomas, A.W., van Dijk, M.R., Janse, C.J.

“…The stable genetic transformation of three phylogenetically diverse species ofPlasmodium,the parasitic etiological agent of malaria, is now possible. The…”
Get full text

Complement-Like Protein TEP1 Is a Determinant of Vectorial Capacity in the Malaria Vector Anopheles gambiae by Blandin, Stephanie, Shiao, Shin-Hong, Moita, Luis F, Janse, Chris J, Waters, Andrew P, Kafatos, Fotis C, Levashina, Elena A

“…Anopheles mosquitoes are major vectors of human malaria in Africa. Large variation exists in the ability of mosquitoes to serve as vectors and to transmit…”
Get full text

Proteome Analysis of Separated Male and Female Gametocytes Reveals Novel Sex-Specific Plasmodium Biology by Khan, Shahid M., Franke-Fayard, Blandine, Mair, Gunnar R., Lasonder, Edwin, Janse, Chris J., Mann, Matthias, Waters, Andrew P.

“…Gametocytes, the precursor cells of malaria-parasite gametes, circulate in the blood and are responsible for transmission from host to mosquito vector. The…”
Get full text

A Plasmodium berghei reference line that constitutively expresses GFP at a high level throughout the complete life cycle by Franke-Fayard, Blandine, Trueman, Holly, Ramesar, Jai, Mendoza, Jacqui, van der Keur, Maarten, van der Linden, Reinier, Sinden, Robert E., Waters, Andrew P., Janse, Chris J.

“…Green fluorescent protein (GFP) is a well-established reporter protein for the examination of biological processes. This report describes a recombinant…”
Get full text

Comparison of in vivo and in vitro antimalarial activity of artemisinin, dihydroartemisinin and sodium artesunate in the Plasmodium berghei-rodent model by Janse, C J, Waters, A P, Kos, J, Lugt, C B

“…The in vitro and in vivo antimalarial activity of artemisinin, artesunate and dihydroartemisinin has been compared using the Plasmodium berghei-rodent model…”
Get more information

Real‐time, in vivo analysis of malaria ookinete locomotion and mosquito midgut invasion by Vlachou, Dina, Zimmermann, Timo, Cantera, Rafael, Janse, Chris J., Waters, Andrew P., Kafatos, Fotis C.

“…Summary Invasion of the Anopheles mosquito midgut by the Plasmodium ookinete is a critical step in the malaria transmission cycle. We have generated a…”
Get full text

A Central Role for P48/45 in Malaria Parasite Male Gamete Fertility by van Dijk, Melissa R., Janse, Chris J., Thompson, Joanne, Waters, Andrew P., Braks, Joanna A.M., Dodemont, Huub J., Stunnenberg, Henk G., van Gemert, Geert-Jan, Sauerwein, Robert W., Eling, Wijnand

“…Fertilization and zygote development are obligate features of the malaria parasite life cycle and occur during parasite transmission to mosquitoes. The surface…”
Get full text

Occurrence of Fusarium‐produced naphthazarins in citrus trees and sensitivity of rootstocks to isomarticin in relation to citrus blight by Janse van Rensburg, J. C., Labuschagne, N., Nemec, S.

“…Fusarium solani, the causal fungus of root and crown rot of citrus, produces naphthazarin toxins that were shown to be toxic to citrus plants. It was found…”
Get full text

Malaria Vaccines: Back to the Future? by Waters, A. P., Mota, M. M., van Dijk, M. R., Janse, C. J.

“…Malaria is the scourge of many developing countries, particularly those in sub-Saharan Africa, claiming several million lives each year. Here, Waters et al…”
Get full text

Transgenic expression of a mosquito-stage malarial protein, Pbs21, in blood stages of transformed Plasmodium berghei and induction of an immune response upon infection by MARGOS, G, VAN DIJK, M. R, RAMESAR, J, JANSE, C. J, WATERS, A. P, SINDEN, R. E

“…Pbs21 is a surface protein of the ookinete of Plasmodium berghei, which can induce a potent transmission-blocking immune response. Pbs21 is normally expressed…”
Get full text

P25 and P28 proteins of the malaria ookinete surface have multiple and partially redundant functions by Tomas, Ana M., Margos, Gabriele, Dimopoulos, George, van Lin, Leo H.M., de Koning-Ward, Tania F., Sinha, Ria, Lupetti, Pietro, Beetsma, Annette L., Rodriguez, Maria C., Karras, Marianna, Hager, Ariadne, Mendoza, Jacqui, Butcher, Geoffrey A., Kafatos, Fotis, Janse, Chris J., Waters, Andrew P., Sinden, Robert E.

“…The ookinete surface proteins (P25 and P28) are proven antimalarial transmission‐blocking vaccine targets, yet their biological functions are unknown. By using…”
Get full text

Chromosome translocation in Plasmodium berghei by Janse, C.J., Ramesar, J., Mons, B.

“…We decribe a chromosome translocation in a karyotype mutant of the rodent malarial parasite Plasmodium berghei. In this mutant (named EP) a small chromosome…”
Get full text

Circumsporozoite protein is required for development of malaria sporozoites in mosquitoes by Ménard, R, Sultan, A A, Cortes, C, Altszuler, R, van Dijk, M R, Janse, C J, Waters, A P, Nussenzweig, R S, Nussenzweig, V

“…Malaria parasites undergo a sporogonic cycle in the mosquito vector. Sporozoites, the form of the parasite injected into the host during a bloodmeal, develop…”
Get full text

The A-domain and the thrombospondin-related motif of Plasmodium falciparum TRAP are implicated in the invasion process of mosquito salivary glands by Wengelnik, Kai, Spaccapelo, Roberta, Naitza, Silvia, Robson, Kathryn J.H., Janse, Chris J., Bistoni, Francesco, Waters, Andrew P., Crisanti, Andrea

“…Sporozoites from all Plasmodium species analysed so far express the thrombospondin‐related adhesive protein (TRAP), which contains two distinct adhesive…”
Get full text

Parasitology. Malaria vaccines: back to the future? by Waters, A P, Mota, M M, van Dijk, M R, Janse, C J

Get full text