Search Results - "Janowska, K"

Mechanistic insight into the relationship between N-terminal acetylation of α-synuclein and fibril formation rates by NMR and fluorescence by Kang, Lijuan, Janowska, Maria K, Moriarty, Gina M, Baum, Jean

“…Aggregation of α-synuclein (αSyn), the primary protein component in Lewy body inclusions of patients with Parkinson's disease, arises when the normally soluble…”
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HDXBoxeR: an R package for statistical analysis and visualization of multiple Hydrogen–Deuterium Exchange Mass-Spectrometry datasets of different protein states by Janowska, Maria K, Reiter, Katherine, Magala, Pearl, Guttman, Miklos, Klevit, Rachel E

“…Abstract Summary Hydrogen–Deuterium Exchange Mass Spectrometry (HDX-MS) is a powerful protein characterization technique that provides insights into protein…”
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Mechanisms of Small Heat Shock Proteins by Janowska, Maria K, Baughman, Hannah E R, Woods, Christopher N, Klevit, Rachel E

“…Small heat shock proteins (sHSPs) are ATP-independent chaperones that delay formation of harmful protein aggregates. sHSPs' role in protein homeostasis has…”
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Who with whom: functional coordination of E2 enzymes by RING E3 ligases during poly‐ubiquitylation by Lips, Christian, Ritterhoff, Tobias, Weber, Annika, Janowska, Maria K, Mustroph, Mandy, Sommer, Thomas, Klevit, Rachel E

“…Protein modification with poly‐ubiquitin chains is a crucial process involved in a myriad of cellular pathways. Chain synthesis requires two steps: substrate…”
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Computational Analysis of Binding of the GBD Domain of WASP to Different Binding Partners by K. Janowska, Maria, Zubac, Ruben, Zagrovic, Bojan

“…The GTP-ase binding domain (GBD) of the signaling protein Wiskott-Aldrich Syndrome Protein (WASP) is intrinsically disordered and mutations in it have been…”
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Unveiling transient protein-protein interactions that modulate inhibition of alpha-synuclein aggregation by beta-synuclein, a pre-synaptic protein that co-localizes with alpha-synuclein by Janowska, Maria K., Wu, Kuen-Phon, Baum, Jean

“…Pathology in Parkinson’s disease is linked to self-association of α-Synuclein (αS) into pathogenic oligomeric species and highly ordered amyloid fibrils…”
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The loss of inhibitory C‐terminal conformations in disease associated P123H β‐synuclein by Janowska, Maria K., Baum, Jean

“…β‐synuclein (βS) is a homologue of α‐synuclein (αS), the major protein component of Lewy bodies in patients with Parkinson's disease. In contrast to αS, βS…”
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High-Performance Workflow for Identifying Site-Specific Crosslinks Originating from a Genetically Incorporated, Photoreactive Amino Acid by Ulmer, Lindsey D., Canzani, Daniele, Woods, Christopher N., Stone, Natalie L., Janowska, Maria K., Klevit, Rachel E., Bush, Matthew F.

“…In conventional crosslinking mass spectrometry, proteins are crosslinked using a highly selective, bifunctional chemical reagent, which limits crosslinks to…”
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A pH-dependent switch promotes β-synuclein fibril formation via glutamate residues by Moriarty, Gina M., Olson, Michael P., Atieh, Tamr B., Janowska, Maria K., Khare, Sagar D., Baum, Jean

“…α-Synuclein (αS) is the primary protein associated with Parkinson's disease, and it undergoes aggregation from its intrinsically disordered monomeric form to a…”
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Intermolecular Paramagnetic Relaxation Enhancement (PRE) Studies of Transient Complexes in Intrinsically Disordered Proteins by Janowska, Maria K, Baum, Jean

“…NMR interchain paramagnetic relaxation enhancement (PRE) techniques are a very powerful approach for detecting transient interchain interactions between…”
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Exploring the accessible conformations of N-terminal acetylated α-synuclein by Moriarty, Gina M., Janowska, Maria K., Kang, Lijuan, Baum, Jean

“…Alpha synuclein (αsyn) fibrils are found in the Lewy Bodies of patients with Parkinson’s disease (PD). The aggregation of the αsyn monomer to soluble oligomers…”
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Cullin-independent recognition of HHARI substrates by a dynamic RBR catalytic domain by Reiter, Katherine H., Zelter, Alex, Janowska, Maria K., Riffle, Michael, Shulman, Nicholas, MacLean, Brendan X., Tamura, Kaipo, Chambers, Matthew C., MacCoss, Michael J., Davis, Trisha N., Guttman, Miklos, Brzovic, Peter S., Klevit, Rachel E.

“…RING-between-RING (RBR) E3 ligases mediate ubiquitin transfer through an obligate E3-ubiquitin thioester intermediate prior to substrate ubiquitination…”
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The application of fungal endoxylanase in bread-making by Romanowska, I, Polak, J, Janowska, K, Bielecki, S

“…The endoxylanase from Aspergillus niger IBT-90 with the specific activity of 21.3 U/mg protein was used for improvement of wheat-rye and whole-meal bread. The…”
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Isolation and characterization of IgG3 glycan-targeting antibodies with exceptional cross-reactivity for diverse viral families by Vukovich, Matthew J, Shiakolas, Andrea R, Lindenberger, Jared, Richardson, Robert A, Bass, Lindsay E, Barr, Maggie, Liu, Yanshun, Go, Eden P, Park, Chan Soo, May, Aaron J, Sammour, Salam, Kambarami, Chipo, Huang, Xiao, Janowska, Katarzyna, Edwards, Robert J, Mansouri, Katayoun, Spence, Taylor N, Abu-Shmais, Alexandra A, Manamela, Nelia P, Richardson, Simone I, Leonard, Sabina E W, Gripenstraw, Kathryn R, Setliff, Ian, Saunders, Kevin O, Bonami, Rachel H, Ross, Ted M, Desaire, Heather, Moore, Penny L, Parks, Robert, Haynes, Barton F, Sheward, Daniel J, Acharya, Priyamvada, Sautto, Giuseppe A, Georgiev, Ivelin S

“…Broadly reactive antibodies that target sequence-diverse antigens are of interest for vaccine design and monoclonal antibody therapeutic development because…”
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Biologic heterogeneity of angiomatous meningiomas by Janowska, K, Kordek, R, Biernat, W, Liberski, P P, Krul, W, Debiec-Rychter, M

“…Three angiomatous meningiomas, classified histologically as benign, were analyzed cytogenetically and examined for the expression of EGF/PDGF and their…”
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The loss of inhibitory C-terminal conformations in disease associated P123H [beta]-synuclein by Janowska, Maria K, Baum, Jean

“…[beta]-synuclein ([beta]S) is a homologue of [alpha]-synuclein ([alpha]S), the major protein component of Lewy bodies in patients with Parkinson's disease. In…”
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Growth of apple-tree seedlings (Malus domesticd) Borkh cv. Antonówka obtained from non-stratified embryos by Czerski, J, Janowska, K

“…The growth of seedlings (Malus domestica Borkh cv. Antonówka) obtained from embryos isolated from non-stratified and stratified (90 days at 4-5°C) seeds was…”
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Aggregation inhibition of Parkinson's related alpha-synuclein through interactions with its homolog beta-synuclein by Janowska, Maria K

“…Alpha-synuclein (αS) and beta-synuclein (βS) are small pre-synaptic, neuronal proteins, which have high sequence similarity, co-localize and very likely play a…”
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A case of amaurotic juvenile idiocy with a non-calcifying meningio-cerebral angiomatosis by Osetowska, E, Janowska, K

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