Search Results - "Janovick, J A"

Participation of the endoplasmic reticulum protein chaperone thio-oxidoreductase in gonadotropin-releasing hormone receptor expression at the plasma membrane by Lucca-Junior, W, Janovick, J A, Conn, P M

“…Chaperone members of the protein disulfide isomerase family can catalyze the thiol-disulfide exchange reaction with pairs of cysteines. There are 14 protein…”
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Rescue of hypogonadotropic hypogonadism-causing and manufactured GnRH receptor mutants by a specific protein-folding template: Misrouted proteins as a novel disease etiology and therapeutic target by JANOVICK, Jo Ann, MAYA-NUNEZ, Guadalupe, CONN, P. Michael

“…In the present study, we demonstrate pharmacological rescue (assessed by ligand binding and restoration of receptor coupling to effector) of five naturally…”
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A cholera toxin-sensitive guanyl nucleotide binding protein mediates the movement of pituitary luteinizing hormone into a releasable pool: loss of this event is associated with the onset of homologous desensitization to gonadotropin-releasing hormone by Janovick, J A, Conn, P M

“…Cholera toxin (CTX; 5 micrograms/ml), but not pertussis toxin (100 ng/ml), when preincubated with pituitary cells for 18 h, enhances the percentage of cellular…”
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Mutations at the Consensus Phosphorylation Sites in the Third Intracellular Loop of the Rat Gonadotropin-Releasing Hormone Receptor: Effects on Receptor Ligand Binding and Signal Transduction by Lin, X, Janovick, J A, Conn, P M

“…In this study, site-directed mutagenesis of potential phosphorylation sites (Thr 238 , Ser 253 , and Thr 264 ) for protein kinase C and C-terminal portion (Ala…”
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Specific identification and subcellular localization of three calmodulin-binding proteins in the rat gonadotrope: spectrin, caldesmon, and calcineurin by NATARAJAN, K, NESS, J, WOOGE, C. H, JANOVICK, J. A, CONN, P. M

“…In an effort to characterize the second messenger system for LH release, we have previously identified five calmodulin-binding proteins in rat gonadotropes of…”
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Gonadotropin-releasing hormone-stimulated intracellular Ca2+ fluctuations and luteinizing hormone release can be uncoupled from inositol phosphate production by Hawes, B E, Waters, S B, Janovick, J A, Bleasdale, J E, Conn, P M

“…In order to study the dependence of GnRH-stimulated LH release on inositol phosphate (IP) turnover, this study used an inhibitor of phospholipase C activity,…”
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Addition of catfish gonadotropin-releasing hormone (GnRH) receptor intracellular carboxyl-terminal tail to rat GnRH receptor alters receptor expression and regulation by Lin, X, Janovick, J A, Brothers, S, Blömenrohr, M, Bogerd, J, Conn, P M

“…Mammalian GnRH receptor (GnRHR) is unique among G protein-coupled seven-transmembrane segment receptors due to the absence of an intracellular C-terminal tail…”
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Differential orientation of a GnRH agonist and antagonist in the pituitary GnRH receptor by Janovick, J A, Haviv, F, Fitzpatrick, T D, Conn, P M

“…In the present study we have used a high affinity photoaffinity label (PAL) agonist (pGlu-His-Trp-Ser-125I-iodoTyr-D-Lys(para-N3-Benzoyl)-Leu-Arg-P roNHEt) and…”
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Regulation of G(q/11)alpha by the gonadotropin-releasing hormone receptor by Stanislaus, D, Janovick, J A, Brothers, S, Conn, P M

“…Evidence from use of pertussis and cholera toxins and from NaF suggested the involvement of G proteins in GnRH regulation of gonadotrope function. We have used…”
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Caldesmon: a bifunctional (calmodulin and actin) binding protein which regulates stimulated gonadotropin release by Janovick, J A, Natarajan, K, Longo, F, Conn, P M

“…Calmodulin (CaM) serves as an intracellular Ca2+ receptor in the gonadotrope and appears to mediate GnRH-stimulated gonadotropin release. Recently we have…”
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Stable transfection of GH3 cells with rat gonadotropin-releasing hormone receptor complementary deoxyribonucleic acid results in expression of a receptor coupled to cyclic adenosine 3',5'-monophosphate-dependent prolactin release via a G-protein by Kuphal, D, Janovick, J A, Kaiser, U B, Chin, W W, Conn, P M

“…GH3 cells, which normally release PRL in response to stimulation by TRH, have been stably transfected with rat GnRH receptor complementary DNA (GGH3-1' cells)…”
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Gonadotropin-releasing hormone modulation of protein kinase-C activity in perifused anterior pituitary cell cultures by Andrews, W V, Hansen, J R, Janovick, J A, Conn, P M

“…The ability of GnRH to modulate protein kinase-C (PKC) activity was examined in perifused rat pituitary cell cultures. Under these conditions, LH release and…”
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Molecular cloning and expression of two type one somatostatin receptors in goldfish brain by Lin, X, Janovick, J A, Brothers, S, Conn, P M, Peter, R E

“…Somatostatin (SRIF or SS) exerts diverse inhibitory actions through binding to specific receptors. In this study, two SRIF receptor complementary DNAs (cDNAs)…”
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Mechanisms mediating multiple physiological responses to gonadotropin-releasing hormone by Stanislaus, Dinesh, Pinter, Jonathon H, Janovick, Jo Ann, Conn, P.Michael

“…A central question in endocrinology is how a single ligand interacting with a single receptor can mediate multiple responses. GnRH interaction with receptor…”
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Structure-Activity Relationships of G Protein-Coupled Receptors by Ulloa-Aguirre, Alfredo, Stanislaus, Dinesh, Janovick, Jo Ann, Conn, P.Michael

“…The primary function of cell-surface receptors is to discriminate the specific signaling molecule or ligand from a large array of chemically diverse…”
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Molecular cloning and expression of a type-two somatostatin receptor in goldfish brain and pituitary by Lin, Xinwei, Janovick, Jo Ann, Cardenas, Rodolfo, Conn, P.Michael, Peter, Richard E

“…Somatostatin (SRIF or SS) exerts diverse inhibitory actions through binding to specific receptors. In this study, a SRIF receptor cDNA was cloned and sequenced…”
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A mathematical model quantifying GnRH-induced LH secretion from gonadotropes by Blum, J J, Reed, M C, Janovick, J A, Conn, P M

“…A mathematical model is developed to investigate the rate of release of luteinizing hormone (LH) from pituitary gonadotropes in response to short pulses of…”
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Gonadotropin releasing hormone agonist provokes homologous receptor microaggregation: an early event in seven-transmembrane receptor mediated signaling by Janovick, J A, Conn, P M

“…Gonadotropin releasing hormone (GnRH) mediates interactions between the neural and the endocrine systems. The GnRH receptor is a member of the ubiquitous…”
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Combined modification of intracellular and extracellular loci on human gonadotropin-releasing hormone receptor provides a mechanism for enhanced expression by Maya-Núñez, G, Janovick, J A, Conn, P M

“…The mammalian gonadotropin-releasing hormone (GnRH) receptor (GnRH-R) has been a therapeutic target for human and animal medicine. This receptor is a unique…”
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Molecular and cellular bases of gonadotropin-releasing hormone action in the pituitary and central nervous system by Conn, P M, Janovick, J A, Stanislaus, D, Kuphal, D, Jennes, L

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