Search Results - "Janoschka, Claudia"

Human CCR5high effector memory cells perform CNS parenchymal immune surveillance via GZMK-mediated transendothelial diapedesis by Herich, Sebastian, Schneider-Hohendorf, Tilman, Rohlmann, Astrid, Khaleghi Ghadiri, Maryam, Schulte-Mecklenbeck, Andreas, Zondler, Lisa, Janoschka, Claudia, Ostkamp, Patrick, Richter, Jannis, Breuer, Johanna, Dimitrov, Stoyan, Rammensee, Hans-Georg, Grauer, Oliver M, Klotz, Luisa, Gross, Catharina C, Stummer, Walter, Missler, Markus, Zarbock, Alexander, Vestweber, Dietmar, Wiendl, Heinz, Schwab, Nicholas

“…Although the CNS is immune privileged, continuous search for pathogens and tumours by immune cells within the CNS is indispensable. Thus, distinct immune-cell…”
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High anti-JCPyV serum titers coincide with high CSF cell counts in RRMS patients by Schneider-Hohendorf, Tilman, Schulte-Mecklenbeck, Andreas, Ostkamp, Patrick, Janoschka, Claudia, Pawlitzki, Marc, Luessi, Felix, Zipp, Frauke, Meuth, Sven G, Klotz, Luisa, Wiendl, Heinz, Gross, Catharina C, Schwab, Nicholas

“…Background: Progressive multifocal leukoencephalopathy (PML) can in rare cases occur in natalizumab-treated patients with high serum anti-JCPyV antibodies,…”
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Immune Cell Profiling During Switching from Natalizumab to Fingolimod Reveals Differential Effects on Systemic Immune-Regulatory Networks and on Trafficking of Non-T Cell Populations into the Cerebrospinal Fluid-Results from the ToFingo Successor Study by Lohmann, Lisa, Janoschka, Claudia, Schulte-Mecklenbeck, Andreas, Klinsing, Svenja, Kirstein, Lucienne, Hanning, Uta, Wirth, Timo, Schneider-Hohendorf, Tilman, Schwab, Nicholas, Gross, Catharina C, Eveslage, Maria, Meuth, Sven G, Wiendl, Heinz, Klotz, Luisa

“…Leukocyte sequestration is an established therapeutic concept in multiple sclerosis (MS) as represented by the trafficking drugs natalizumab (NAT) and…”
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RGS2 drives male aggression in mice via the serotonergic system by Mark, Melanie D., Wollenweber, Patric, Gesk, Annika, Kösters, Katja, Batzke, Katharina, Janoschka, Claudia, Maejima, Takashi, Han, Jing, Deneris, Evan S., Herlitze, Stefan

“…Aggressive behavior in our modern, civilized society is often counterproductive and destructive. Identifying specific proteins involved in the disease can…”
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Single-cell profiling reveals preferential reduction of memory B cell subsets in cladribine patients that correlates with treatment response by Teschner, Valerie E., Fleck, Ann-Katrin, Walter, Carolin, Schwarze, Anna-Sophie, Eschborn, Melanie, Wirth, Timo, Steinberg, Olga V., Schulte-Mecklenbeck, Andreas, Lu, I-Na, Herrera-Rivero, Marisol, Janoschka, Claudia, Lünemann, Jan D., Schwab, Nicholas, Meyer zu Hörste, Gerd, Varghese, Julian, Gross, Catharina C., Pul, Refik, Kleinschnitz, Christoph, Mader, Simone, Meinl, Edgar, Stoll, Monika, Wiendl, Heinz, Klotz, Luisa

“…Background: Cladribine is a highly effective immunotherapy that is applied in two short-term courses over 2 years and reduces relapse rate and disease…”
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Back to the roots - from Phenotype to Genotype in Monozygotic Twins discordant for Multiple Sclerosis“ (P1-1.Virtual) by Janoschka, Claudia, Herrera-Rivero, Marisol, Gerdes, Lisa, Koch, Kathrin, Wiendl, Heinz, Hohlfeld, Reinhard, Stoll, Monika, Klotz, Luisa

“…Abstract only…”
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Broader Epstein-Barr virus-specific T cell receptor repertoire in patients with multiple sclerosis by Schneider-Hohendorf, Tilman, Gerdes, Lisa Ann, Pignolet, Béatrice, Gittelman, Rachel, Ostkamp, Patrick, Rubelt, Florian, Raposo, Catarina, Tackenberg, Björn, Riepenhausen, Marianne, Janoschka, Claudia, Wünsch, Christian, Bucciarelli, Florence, Flierl-Hecht, Andrea, Beltrán, Eduardo, Kümpfel, Tania, Anslinger, Katja, Gross, Catharina C, Chapman, Heidi, Kaplan, Ian, Brassat, David, Wekerle, Hartmut, Kerschensteiner, Martin, Klotz, Luisa, Lünemann, Jan D, Hohlfeld, Reinhard, Liblau, Roland, Wiendl, Heinz, Schwab, Nicholas

“…Epstein-Barr virus (EBV) infection precedes multiple sclerosis (MS) pathology and cross-reactive antibodies might link EBV infection to CNS autoimmunity. As an…”
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Dietary conjugated linoleic acid links reduced intestinal inflammation to amelioration of CNS autoimmunity by Fleck, Ann-Katrin, Hucke, Stephanie, Teipel, Flavio, Eschborn, Melanie, Janoschka, Claudia, Liebmann, Marie, Wami, Haleluya, Korn, Lisanne, Pickert, Geethanjali, Hartwig, Marvin, Wirth, Timo, Herold, Martin, Koch, Kathrin, Falk-Paulsen, Maren, Dobrindt, Ulrich, Kovac, Stjepana, Gross, Catharina C, Rosenstiel, Philip, Trautmann, Marcel, Wiendl, Heinz, Schuppan, Detlef, Kuhlmann, Tanja, Klotz, Luisa

“…A close interaction between gut immune responses and distant organ-specific autoimmunity including the CNS in multiple sclerosis has been established in recent…”
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Immune signatures of prodromal multiple sclerosis in monozygotic twins by Gerdes, Lisa Ann, Janoschka, Claudia, Eveslage, Maria, Mannig, Bianca, Wirth, Timo, Schulte-Mecklenbeck, Andreas, Lauks, Sarah, Glau, Laura, Gross, Catharina C., Tolosa, Eva, Flierl-Hecht, Andrea, Ertl-Wagner, Birgit, Barkhof, Frederik, Meuth, Sven G., Kümpfel, Tania, Wiendl, Heinz, Hohlfeld, Reinhard, Klotz, Luisa

“…The tremendous heterogeneity of the human population presents a major obstacle in understanding how autoimmune diseases like multiple sclerosis (MS) contribute…”
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Dimethyl fumarate treatment restrains the antioxidative capacity of T cells to control autoimmunity by Liebmann, Marie, Korn, Lisanne, Janoschka, Claudia, Albrecht, Stefanie, Lauks, Sarah, Herrmann, Alexander M, Schulte-Mecklenbeck, Andreas, Schwab, Nicholas, Schneider-Hohendorf, Tilman, Eveslage, Maria, Wildemann, Brigitte, Luessi, Felix, Schmidt, Stephan, Diebold, Martin, Bittner, Stefan, Gross, Catharina C, Kovac, Stjepana, Zipp, Frauke, Derfuss, Tobias, Kuhlmann, Tanja, König, Simone, Meuth, Sven G, Wiendl, Heinz, Klotz, Luisa

“…Dimethyl fumarate, an approved treatment for relapsing-remitting multiple sclerosis, exerts pleiotropic effects on immune cells as well as CNS resident cells…”
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Dietary wheat amylase trypsin inhibitors exacerbate CNS inflammation in experimental multiple sclerosis by Zevallos, Victor F, Yogev, Nir, Hauptmann, Judith, Nikolaev, Alexei, Pickert, Geethanjali, Heib, Valeska, Fittler, Nicola, Steven, Sebastian, Luessi, Felix, Neerukonda, Manjusha, Janoschka, Claudia, Tobinski, Ann-Marie, Klotz, Luisa, Waisman, Ari, Schuppan, Detlef

“…Wheat has become a main staple globally. We studied the effect of defined pro-inflammatory dietary proteins, wheat amylase trypsin inhibitors (ATI), activating…”
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Enhanced pathogenicity of Th17 cells due to natalizumab treatment: Implications for MS disease rebound by Janoschka, Claudia, Lindner, Maren, Koppers, Nils, Starost, Laura, Liebmann, Marie, Eschborn, Melanie, Schneider-Hohendorf, Tilman, Windener, Farina, Schafflick, David, Fleck, Ann-Katrin, Koch, Kathrin, Deffner, Marie, Schwarze, Anna-Sophie, Schulte-Mecklenbeck, Andreas, Metz, Imke, Meuth, Sven G, Gross, Catharina C, Meyer Zu Hörste, Gerd, Schwab, Nicholas, Kuhlmann, Tanja, Wiendl, Heinz, Stoll, Monika, Klotz, Luisa

“…After natalizumab (NAT) cessation, some multiple sclerosis (MS) patients experience a severe disease rebound. The rebound pathophysiology is still unclear;…”
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Dimethyl fumarate treatment alters T cell metabolism in multiple sclerosis (1142) by Liebmann, Marie, Janoschka, Claudia, Herrmann, Alexander, Korn, Lisanne, Schulte-Mecklenbeck, Andreas, Schwab, Nicholas, Kovac, Stjepana, Gross, Catharina C., König, Simone, Meuth, Sven, Wiendl, Heinz, Klotz, Luisa

“…Abstract only…”
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Correction: Broader Epstein–Barr virus–specific T cell receptor repertoire in patients with multiple sclerosis by Schneider-Hohendorf, Tilman, Gerdes, Lisa Ann, Pignolet, Béatrice, Gittelman, Rachel, Ostkamp, Patrick, Rubelt, Florian, Raposo, Catarina, Tackenberg, Björn, Riepenhausen, Marianne, Janoschka, Claudia, Wünsch, Christian, Bucciarelli, Florence, Flierl-Hecht, Andrea, Beltrán, Eduardo, Kümpfel, Tania, Anslinger, Katja, Gross, Catharina C., Chapman, Heidi, Kaplan, Ian, Brassat, David, Wekerle, Hartmut, Kerschensteiner, Martin, Klotz, Luisa, Lünemann, Jan D., Hohlfeld, Reinhard, Liblau, Roland, Wiendl, Heinz, Schwab, Nicholas

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Long-term natalizumab treatment enhances the pathogenic signature of Th17 cells – potential implications for treatment cessation? (P2.408) by Janoschka, Claudia, Lohmann, Lisa, Schulte-Mecklenbeck, Andreas, Schneider-Hohendorf, Tilman, Schwab, Nicholas, Groß, Catharina, Wiendl, Heinz, Klotz, Luisa

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B7-H1 shapes T-cell–mediated brain endothelial cell dysfunction and regional encephalitogenicity in spontaneous CNS autoimmunity by Klotz, Luisa, Kuzmanov, Ivan, Hucke, Stephanie, Gross, Catharina C., Posevitz, Vilmos, Dreykluft, Angela, Schulte-Mecklenbeck, Andreas, Janoschka, Claudia, Lindner, Maren, Herold, Martin, Schwab, Nicholas, Ludwig-Portugall, Isis, Kurts, Christian, Meuth, Sven G., Kuhlmann, Tanja, Wiendl, Heinz

“…Molecular mechanisms that determine lesion localization or phenotype variation in multiple sclerosis are mostly unidentified. Although transmigration of…”
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Immune Cell Profiling during Switching from Natalizumab to Fingolimod Reveals Differential Effects on Systemic Immune-Regulatory Networks and on Trafficking of non-T Cell Populations into the CSF – Results from the ToFingo Successor Study (S52.002) by Lohmann, Lisa, Janoschka, Claudia, Schulte-Mecklenbeck, Andreas, Klinsing, Svenja, Wirth, Timo, Schneider-Hohendorf, Tilman, Schwab, Nicholas, Gross, Catharina C., Eveslage, Maria, Meuth, Sven G., Wiendl, Heinz, Klotz, Luisa

“…Abstract only…”
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Dimethyl Fumarate Treatment alters T Cell Metabolism in Multiple Sclerosis (P1.414) by Liebmann, Marie, Janoschka, Claudia, Herrmann, Alexander, Schulte-Mecklenbeck, Andreas, Schwab, Nicolas, Gross, Catharina C., Meuth, Sven G., Wiendl, Heinz, Klotz, Luisa

“…Abstract only…”
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RGS2 drives male aggression in mice via the serotonergic system by Mark, Melanie D, Wollenweber, Patric, Gesk, Annika, Kösters, Katja, Batzke, Katharina, Janoschka, Claudia, Maejima, Takashi, Han, Jing, Deneris, Evan S, Herlitze, Stefan

“…Aggressive behavior in our modern, civilized society is often counterproductive and destructive. Identifying specific proteins involved in the disease can…”
Get full text