Search Results - "Janneh, O"

Doxorubicin induced myocardial injury is exacerbated following ischaemic stress via opening of the mitochondrial permeability transition pore by Gharanei, M., Hussain, A., Janneh, O., Maddock, H.L.

“…Chemotherapeutic agents such as doxorubicin are known to cause or exacerbate cardiovascular cell death when an underlying heart condition is present. However,…”
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Cultured CD4T cells and primary human lymphocytes express hOATPs: intracellular accumulation of saquinavir and lopinavir by Janneh, O, Hartkoorn, R C, Jones, E, Owen, A, Ward, S A, Davey, R, Back, D J, Khoo, S H

“…Background and purpose: Drug efflux tranporters (P‐glycoprotein (P‐gp), multidrug resistance‐associated protein (MRP)) limit the cellular uptake of human…”
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P664The anti-cancer drug Artemisinin protects against myocardial ischaemia-reperfusion injury via the recruitment of PI3K-AKT-p70S6k cell survival pathway by Babba, M, Janneh, O, Maddock, HL, Hussain, A

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Inhibition of P-glycoprotein and multidrug resistance-associated proteins modulates the intracellular concentration of lopinavir in cultured CD4 T cells and primary human lymphocytes by Janneh, Omar, Jones, Elizabeth, Chandler, Becky, Owen, Andrew, Khoo, Saye H.

“…Background HIV protease inhibitors (HPIs) are an important component of highly active antiretroviral therapy. However, the activity of drug efflux…”
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The effect of benomyl on neurite outgrowth in mouse NB2A and human SH-SY5Y neuroblastoma cells in vitro by McLean, W G, Holme, A D, Janneh, O, Southgate, A, Howard, C V, Reed, M G

“…The commercial fungicide methyl 1-[(butylamino) carbonyl]-1H-benzimidazol-2-ylcarbamate (benomyl) is teratogenic in rats. Its mode of action is believed to be…”
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Intracellular accumulation of efavirenz and nevirapine is independent of P-glycoprotein activity in cultured CD4 T cells and primary human lymphocytes by Janneh, Omar, Chandler, Becky, Hartkoorn, Ruben, Kwan, Wai San, Jenkinson, Claire, Evans, Sorcha, Back, David J., Owen, Andrew, Khoo, Saye H.

“…Background Interaction of antiretrovirals with drug transporters such as P-glycoprotein (P-gp), multidrug resistance-associated protein (MRP), breast cancer…”
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Modulation of the intracellular accumulation of saquinavir in peripheral blood mononuclear cells by inhibitors of MRP1, MRP2, P-gp and BCRP by JANNEH, Omar, OWEN, Andrew, CHANDLER, Becky, HARTKOORN, Ruben C, HART, C. Anthony, BRAY, Patrick G, WARD, Stephen A, BACK, David J, KHOO, Saye H

“…The efflux transporters P-glycoprotein (P-gp), multidrug resistance-associated proteins (MRP) and breast cancer resistance protein (BCRP) limit the…”
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P-glycoprotein, multidrug resistance-associated proteins and human organic anion transporting polypeptide influence the intracellular accumulation of atazanavir by JANNEH, Omar, ANWAR, Tariq, JUNGBAUER, Christof, KOPP, Stefan, KHOO, Saye H, BACK, David J, CHIBA, Peter

“…Drug efflux (for example, P-glycoprotein [P-gp], multidrug resistance-associated proteins [MRPs] and breast cancer resistance protein [BCRP]) and influx (for…”
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Evolution of a Unique Plasmodium falciparum Chloroquine-Resistance Phenotype in Association with pfcrt Polymorphism in Papua New Guinea and South America by Mehlotra, Rajeev K., Fujioka, Hisashi, Roepe, Paul D., Janneh, Omar, Lyann M. B. Ursos, Jacobs-Lorena, Vanessa, McNamara, David T., Bockarie, Moses J., Kazura, James W., Kyle, Dennis E., Fidock, David A., Zimmerman, Peter A.

“…The mechanistic basis for chloroquine resistance (CQR) in Plasmodium falciparum recently has been linked to the polymorphic gene pfcrt. Alleles associated with…”
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Cellular Uptake of Chloroquine Is Dependent on Binding to Ferriprotoporphyrin IX and Is Independent of NHE Activity in Plasmodium falciparum by Bray, Patrick G., Janneh, Omar, Raynes, Kaylene J., Mungthin, Mathirut, Ginsburg, Hagai, Ward, Stephen A.

“…Here we provide definitive evidence that chloroquine (CQ) uptake in Plasmodium falciparum is determined by binding to ferriprotoporphyrin IX (FPIX). Specific…”
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Concentration-dependent effects and intracellular accumulation of HIV protease inhibitors in cultured CD4 T cells and primary human lymphocytes by Janneh, Omar, Bray, Patrick G., Jones, Elizabeth, Wyen, Christoph, Chiba, Peter, Back, David J., Khoo, Saye H.

“…Background The intracellular and plasma concentrations of HIV protease inhibitors (HPIs) vary widely in vivo. It is unclear whether there is a…”
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Altered adipokine response in murine 3T3-F442A adipocytes treated with protease inhibitors and nucleoside reverse transcriptase inhibitors by JONES, Simon P, JANNEH, Omar, BACK, David J, PIRMOHAMED, Munir

“…Abnormal levels of tumour necrosis factor (TNF)-alpha, interleukin (IL)-6 and adiponectin have been observed in HIV patients with lipodystrophy. However,…”
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In vitro synergy and enhanced murine brain penetration of saquinavir coadministered with mefloquine by Owen, Andrew, Janneh, Omar, Hartkoorn, Ruben C, Chandler, Becky, Bray, Patrick G, Martin, Phillip, Ward, Stephen A, Hart, C Anthony, Khoo, Saye H, Back, David J

“…Highly active antiretroviral therapy has substantially improved prognosis in human immunodeficiency virus (HIV). However, the integration of proviral DNA,…”
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Intracellular disposition and metabolic effects of zidovudine, stavudine and four protease inhibitors in cultured adipocytes by JANNEH, Omar, HOGGARD, Patrick G, TJIA, John F, JONES, Simon P, KHOO, Saye H, MAHER, Bridget, BACK, David J, PIRMOHAMED, Munir

“…The pathogenesis of lipodystrophy caused by the HIV protease inhibitors (PIs) and nucleoside reverse transcriptase inhibitors (NRTIs) is unclear. We have…”
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Chloroquine uptake and activity is determined by binding to ferriprotoporphyrin IX in Plasmodium falciparum by Bray, P G, Janneh, O, Ward, S A

“…The selective antimalarial activity of chloroquine and related compounds stems from the extensive saturable uptake of these drugs into malaria parasites…”
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