Search Results - "Jankun, J"

Human lipoxygenase: developments in its structure, function, relevance to diseases and challenges in drug development by Skrzypczak-Jankun, E, Jankun, J, Al-Senaidy, A

“…Human lipoxygenases (LOXs) are the enzymes participating in the metabolism of the polyunsaturated fatty acids and catalyzing their oxidation to a variety of…”
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Val17Ile single nucleotide polymorphisms similarly as Ala15Thr could be related to the lower secretory dynamics of PAI-1 secretion: theoretical evidence by Jankun, J, Skrzypczak-Jankun, E

“…Plasminogen activator inhibitor (PAI-1) is a fast acting inhibitor of tissue and urokinase plasminogen activators (tPA and uPA). In that way PAI-1 regulates…”
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Curcumin inhibits lipoxygenase by binding to its central cavity: theoretical and X-ray evidence by Skrzypczak-Jankun, E, McCabe, N P, Selman, S H, Jankun, J

“…Many lipoxygenase inhibitors including curcumin are currently being studied for their anti-carcinogenic properties. Curcumin is a naturally occurring…”
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Why drinking green tea could prevent cancer by Jankun, J, Selman, S H, Swiercz, R, Skrzypczak-Jankun, E

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GOModeler--a tool for hypothesis-testing of functional genomics datasets by Manda, Prashanti, Freeman, McKinley G, Bridges, Susan M, Jankun-Kelly, T J, Nanduri, Bindu, McCarthy, Fiona M, Burgess, Shane C

“…Functional genomics technologies that measure genome expression at a global scale are accelerating biological knowledge discovery. Generating these high…”
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Binding site of amiloride to urokinase plasminogen activator depends on species by Jankun, J, Skrzypczak-Jankun, E

“…A novel drug candidate is checked on its potency on animal models before it can advance to human phase of the research. Usually negative results on animal…”
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Effect of crystal freezing and small-molecule binding on internal cavity size in a large protein: X-ray and docking studies of lipoxygenase at ambient and low temperature at 2.0 Å resolution by Skrzypczak-Jankun, E., Borbulevych, O. Y., Zavodszky, M. I., Baranski, M. R., Padmanabhan, K., Petricek, V., Jankun, J.

“…Flash‐freezing is a technique that is commonly used nowadays to collect diffraction data for X‐ray structural analysis. It can affect both the crystal and…”
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Recombinant PAI-1 inhibits angiogenesis and reduces size of LNCaP prostate cancer xenografts in SCID mice by Swiercz, R, Keck, R W, Skrzypczak-Jankun, E, Selman, S H, Jankun, J

“…To understand the fundamental determinants of urokinase plasminogen activator (uPA) driven angiogenesis in cancer we studied how inhibition of uPA activity…”
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Angiostatic activity of synthetic inhibitors of urokinase type plasminogen activator by Swiercz, R, Skrzypczak-Jankun, E, Merrell, M M, Selman, S H, Jankun, J

“…We hypothesize that tumor angiogenesis can be limited by the reduction of enzymatic activity of the urokinase type plasminogen activator. The proposed…”
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Expression of the plasminogen activation system in kidney cancer correlates with its aggressive phenotype by SWIERCZ, R, WOLFE, J. D, ZAHER, A, JANKUN, J

“…Malignant tumors contrast with benign ones in their ability to invade adjacent tissue and to metastasize. The urokinase plasminogen activator is a proteolytic…”
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Toward Visualization for Games: Theory, Design Space, and Patterns by Bowman, B., Elmqvist, N., Jankun-Kelly, T. J.

“…Electronic games are starting to incorporate in-game telemetry that collects data about player, team, and community performance on a massive scale, and as data…”
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Aspirin blocks binding of photosensitizer SnET2 into human serum albumin: implications for photodynamic therapy by Skrzypczak-Jankun, E, Borbulevych, O Y, Melillo, A, Keck, R, Soriano-Garcia, M, Aniola, J, Niedre, M, Lilge, L, Selman, S H, Jankun, J

“…Tin etiopurpurin dichloride (SnET2) is one of the photosensitizers under investigation to be used in photodynamic therapy of prostate cancer. The drug is…”
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Exploratory visual analysis of conserved domains on multiple sequence alignments by Jankun-Kelly, T J, Lindeman, Andrew D, Bridges, Susan M

“…Multiple alignment of protein sequences can provide insight into sequence conservation across many species and thus allow identification of those sections of…”
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An interactive parallel coordinates technique applied to a tropical cyclone climate analysis by Steed, Chad A., Fitzpatrick, Patrick J., Jankun-Kelly, T.J., Yancey, Amber N., Swan II, J. Edward

“…A highly interactive visual analysis system is presented that is based on an enhanced variant of parallel coordinates — a multivariate information…”
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2,3,7,8-tetrachlorodibenzo-p-dioxin Causes Increases in Expression of c-erb-A and Levels of Protein-tyrosine Kinases in Selected Tissues of Responsive Mouse Strains by Bombick, David W., Jankun, Jerzy, Tullis, Kathryn, Matsumura, Fumio

“…2,3,7,8,-Tetrachlorodibenzo-p-dioxin (TCDD) administered in vivo causes drastic reduction in the weight of the mouse thymus at low doses (e.g., 30 μ g/kg…”
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An Evaluation of Glyph Perception for Real Symmetric Traceless Tensor Properties by Jankun-Kelly, T.J., Lanka, Y.S., Swan II, J.E.

“…A perceptual study of four tensor glyphs for symmetric, real, traceless tensors was performed. Each glyph encodes three properties of the system: Orientation,…”
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Fluid interaction for information visualization by Elmqvist, Niklas, Moere, Andrew Vande, Jetter, Hans-Christian, Cernea, Daniel, Reiterer, Harald, Jankun-Kelly, TJ

“…Despite typically receiving little emphasis in visualization research, interaction in visualization is the catalyst for the user's dialogue with the data, and,…”
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Visualization exploration and encapsulation via a spreadsheet-like interface by Jankun-Kelly, T.J., Kwan-Liu Ma

“…Exploring complex, very large data sets requires interfaces to present and navigate through the visualization of the data. Two types of audience benefit from…”
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A Model and Framework for Visualization Exploration by Jankun-Kelly, T.J., Kwan-Liu Ma, Gertz, M.

“…Visualization exploration is the process of extracting insight from data via interaction with visual depictions of that data. Visualization exploration is more…”
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A 2D Flow Visualization User Study Using Explicit Flow Synthesis and Implicit Task Design by Zhanping Liu, Shangshu Cai, Swan, J. Edward, Moorhead, Robert J., Martin, J. P., Jankun-Kelly, T. J.

“…This paper presents a 2D flow visualization user study that we conducted using new methodologies to increase the objectiveness. We evaluated grid-based…”
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