Search Results - "Janke, J. J."

RIPK1 Blocks Early Postnatal Lethality Mediated by Caspase-8 and RIPK3 by Dillon, Christopher P., Weinlich, Ricardo, Rodriguez, Diego A., Cripps, James G., Quarato, Giovanni, Gurung, Prajwal, Verbist, Katherine C., Brewer, Taylor L., Llambi, Fabien, Gong, Yi-Nan, Janke, Laura J., Kelliher, Michelle A., Kanneganti, Thirumala-Devi, Green, Douglas R.

“…Receptor-interacting protein kinase (RIPK)-1 is involved in RIPK3-dependent and -independent signaling pathways leading to cell death and/or inflammation…”
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The many faces of mouse histiocytic sarcoma in C57BL/6J mice by Janke, Laura J., Rehg, Jerold E.

“…Histiocytic sarcoma is a tumor of the hematopoietic system considered to be derived from macrophages. Although rare in humans, it occurs frequently in mice…”
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Extracting Uranium from Seawater: Promising AF Series Adsorbents by Das, S, Oyola, Y, Mayes, Richard T, Janke, Chris J, Kuo, L.-J, Gill, G, Wood, J. R, Dai, S

“…A new family of high-surface-area polyethylene fiber adsorbents named the AF series was recently developed at the Oak Ridge National Laboratory (ORNL). The AF…”
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Uptake of Uranium from Seawater by Amidoxime-Based Polymeric Adsorbent: Field Experiments, Modeling, and Updated Economic Assessment by Kim, Jungseung, Tsouris, Costas, Oyola, Yatsandra, Janke, Christopher J, Mayes, Richard T, Dai, Sheng, Gill, Gary, Kuo, Li-Jung, Wood, Jordana, Choe, Key-Young, Schneider, Erich, Lindner, Harry

“…Uranium recovery from seawater has been investigated for several decades for the purpose of securing nuclear fuel for energy production. In this study, field…”
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Oxaliplatin-induced neurotoxicity is dependent on the organic cation transporter OCT2 by Sprowl, Jason A., Ciarimboli, Giuliano, Lancaster, Cynthia S., Giovinazzo, Hugh, Gibson, Alice A., Du, Guoqing, Janke, Laura J., Cavaletti, Guido, Shields, Anthony F., Sparreboom, Alex

“…Oxaliplatin is an integral component of colorectal cancer therapy, but its clinical use is associated with a dose-limiting peripheral neurotoxicity. We found…”
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Extracting Uranium from Seawater: Promising AI Series Adsorbents by Das, S, Oyola, Y, Mayes, R. T, Janke, C. J, Kuo, L.-J, Gill, G, Wood, J. R, Dai, S

“…A new series of adsorbents (AI10 through AI17) were successfully developed at ORNL by radiation induced graft polymerization (RIGP) of acrylonitrile (AN) and…”
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Survival Function of the FADD-CASPASE-8-cFLIPL Complex by Dillon, Christopher P., Oberst, Andrew, Weinlich, Ricardo, Janke, Laura J., Kang, Tae-Bong, Ben-Moshe, Tehila, Mak, Tak W., Wallach, David, Green, Douglas R.

“…Caspase-8, the initiator caspase of the death receptor pathway of apoptosis, its adapter molecule, FADD, required for caspase-8 activation, and cFLIPL, a…”
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Crenolanib is active against models of drug-resistant FLT3-ITD−positive acute myeloid leukemia by Zimmerman, Eric I., Turner, David C., Buaboonnam, Jassada, Hu, Shuiying, Orwick, Shelley, Roberts, Michael S., Janke, Laura J., Ramachandran, Abhijit, Stewart, Clinton F., Inaba, Hiroto, Baker, Sharyn D.

“…FLT3 kinase internal tandem duplication (ITD) mutations are common in acute myeloid leukemia (AML) and are associated with poor clinical outcomes. Although…”
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Oleic Acid Phase Behavior from Molecular Dynamics Simulations by Janke, J. Joel, Bennett, W. F. Drew, Tieleman, D. Peter

“…Fatty acid aggregation is important for a number of diverse applications: from origins of life research to industrial applications to health and disease…”
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Computational Screening for mAb Colloidal Stability with Coarse-Grained, Molecular-Scale Simulations by Janke, J. Joel, Starr, Charles G., Kingsbury, Jonathan S., Furtmann, Norbert, Roberts, Christopher J., Calero-Rubio, Cesar

“…Monoclonal antibodies (mAbs) are an important modality of protein therapeutics with broad applications for numerous diseases. However, colloidal instabilities…”
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Hybrid Nanorod-Polymer Solar Cells by Huynh, Wendy U., Dittmer, Janke J., Alivisatos, A. Paul

“…We demonstrate that semiconductor nanorods can be used to fabricate readily processed and efficient hybrid solar cells together with polymers. By controlling…”
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The Uranium from Seawater Program at the Pacific Northwest National Laboratory: Overview of Marine Testing, Adsorbent Characterization, Adsorbent Durability, Adsorbent Toxicity, and Deployment Studies by Gill, Gary A, Kuo, Li-Jung, Janke, Chris J, Park, Jiyeon, Jeters, Robert T, Bonheyo, George T, Pan, Horng-Bin, Wai, Chien, Khangaonkar, Tarang, Bianucci, Laura, Wood, Jordana R, Warner, Marvin G, Peterson, Sonja, Abrecht, David G, Mayes, Richard T, Tsouris, Costas, Oyola, Yatsandra, Strivens, Jonathan E, Schlafer, Nicholas J, Addleman, R. Shane, Chouyyok, Wilaiwan, Das, Sadananda, Kim, Jungseung, Buesseler, Ken, Breier, Crystal, D’Alessandro, Evan

“…The Pacific Northwest National Laboratory (PNNL) is evaluating the performance of adsorption materials to extract uranium from natural seawater. Testing…”
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Protective Roles for Caspase-8 and cFLIP in Adult Homeostasis by Weinlich, Ricardo, Oberst, Andrew, Dillon, Christopher P., Janke, Laura J., Milasta, Sandra, Lukens, John R., Rodriguez, Diego A., Gurung, Prajwal, Savage, Chandra, Kanneganti, Thirumala D., Green, Douglas R.

“…Caspase-8 or cellular FLICE-like inhibitor protein (cFLIP) deficiency leads to embryonic lethality in mice due to defects in endothelial tissues. Caspase-8−/−…”
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Mitigation of acute kidney injury by cell-cycle inhibitors that suppress both CDK4/6 and OCT2 functions by Pabla, Navjotsingh, Gibson, Alice A., Buege, Mike, Ong, Su Sien, Li, Lie, Hu, Shuiying, Du, Guoqing, Sprowl, Jason A., Vasilyeva, Aksana, Janke, Laura J., Schlatter, Eberhard, Chen, Taosheng, Ciarimboli, Giuliano, Sparreboom, Alex

“…Acute kidney injury (AKI) is a potentially fatal syndrome characterized by a rapid decline in kidney function caused by ischemic or toxic injury to renal…”
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Classification, Scoring, and Quantification of Cell Death in Tissue Sections by Janke, Laura J., Ward, Jerrold M., Vogel, Peter

“…The analysis and description of the appearance of cell death in tissue sections can add valuable information to research studies. The scoring/grading and…”
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Modeling and targeting of erythroleukemia by hematopoietic genome editing by Iacobucci, Ilaria, Qu, Chunxu, Varotto, Elena, Janke, Laura J., Yang, Xu, Seth, Aman, Shelat, Anang, Friske, Jake D., Fukano, Reiji, Yu, Jiyang, Freeman, Burgess B., Kennedy, James A., Sperling, Adam S., Zheng, Rena, Wang, Yingzhe, Jogiraju, Harini, Dickerson, Kirsten M., Payne-Turner, Debbie, Morris, Sarah M., Hollis, Emily S., Ghosn, Nina, Haggard, Georgia E., Lindsley, R. Coleman, Ebert, Benjamin L., Mullighan, Charles G.

“…Acute erythroid leukemia (AEL) is characterized by a distinct morphology, mutational spectrum, lack of preclinical models, and poor prognosis. Here, using…”
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Mutant Samd9l expression impairs hematopoiesis and induces bone marrow failure in mice by Abdelhamed, Sherif, Thomas, 3rd, Melvin E, Westover, Tamara, Umeda, Masayuki, Xiong, Emily, Rolle, Chandra, Walsh, Michael P, Wu, Huiyun, Schwartz, Jason R, Valentine, Virginia, Valentine, Marcus, Pounds, Stanley, Ma, Jing, Janke, Laura J, Klco, Jeffery M

“…SAMD9 and SAMD9L germline mutations have recently emerged as a new class of predispositions to pediatric myeloid neoplasms. Patients commonly have impaired…”
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Characterization of Heparin’s Conformational Ensemble by Molecular Dynamics Simulations and Nuclear Magnetic Resonance Spectroscopy by Janke, J. Joel, Yu, Yanlei, Pomin, Vitor H, Zhao, Jing, Wang, Chunyu, Linhardt, Robert J, García, Angel E

“…Heparin is a highly charged, polysulfated polysaccharide and serves as an anticoagulant. Heparin binds to multiple proteins throughout the body, suggesting a…”
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Preclinical evaluation of NUDT15-guided thiopurine therapy and its effects on toxicity and antileukemic efficacy by Nishii, Rina, Moriyama, Takaya, Janke, Laura J., Yang, Wenjian, Suiter, Chase C., Lin, Ting-Nien, Li, Lie, Kihira, Kentaro, Toyoda, Hidemi, Hofmann, Ute, Schwab, Matthias, Takagi, Masatoshi, Morio, Tomohiro, Manabe, Atsushi, Kham, Shirley, Jiang, Nan, Rabin, Karen R., Kato, Motohiro, Koh, Katsuyoshi, Yeoh, Allen Eng-Juh, Hori, Hiroki, Yang, Jun J.

“…Thiopurines (eg, 6-mercaptopurine [MP]) are highly efficacious antileukemic agents, but they are also associated with dose-limiting toxicities. Recent studies…”
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The interaction between RIPK1 and FADD controls perinatal lethality and inflammation by Rodriguez, Diego A., Tummers, Bart, Shaw, Jeremy J.P., Quarato, Giovanni, Weinlich, Ricardo, Cripps, James, Fitzgerald, Patrick, Janke, Laura J., Pelletier, Stephane, Crawford, Jeremy Chase, Green, Douglas R.

“…Perturbation of the apoptosis and necroptosis pathways critically influences embryogenesis. Receptor-associated protein kinase-1 (RIPK1) interacts with…”
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