Search Results - "Janka, G. E."

Familial and Acquired Hemophagocytic Lymphohistiocytosis by Janka, G.E

“…Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome in which an uncontrolled and ineffective immune response, triggered in most cases by…”
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Standardized MRD quantification in European ALL trials: Proceedings of the Second International Symposium on MRD assessment in Kiel, Germany, 18-20 September 2008 by Brüggemann, M, Schrauder, A, Raff, T, Pfeifer, H, Dworzak, M, Ottmann, O G, Asnafi, V, Baruchel, A, Bassan, R, Benoit, Y, Biondi, A, Cavé, H, Dombret, H, Fielding, A K, Foà, R, Gökbuget, N, Goldstone, A H, Goulden, N, Henze, G, Hoelzer, D, Janka-Schaub, G E, Macintyre, E A, Pieters, R, Rambaldi, A, Ribera, J-M, Schmiegelow, K, Spinelli, O, Stary, J, von Stackelberg, A, Kneba, M, Schrappe, M, van Dongen, J J M

“…Assessment of minimal residual disease (MRD) has acquired a prominent position in European treatment protocols for patients with acute lymphoblastic leukemia…”
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Co-operative study group for childhood acute lymphoblastic leukemia (COALL) : long-term follow-up of trials 82, 85, 89 and 92 by HARMS, D. O, JANKA-SCHAUB, G. E

“…The German Co-operative Study Group COALL for treatment of acute lymphoblastic leukemia (ALL) in childhood started the first trial in 1980. This report gives…”
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Patient Stratification Based on Prednisolone-Vincristine-Asparaginase Resistance Profiles in Children With Acute Lymphoblastic Leukemia by DEN BOER, M. L, HARMS, D. O, KASPERS, G. J. L, KAMPS, W. A, VAN DER DOES-VAN DEN BERG, A, VAN WERING, E. R, VEERMAN, A. J. P, JANKA-SCHAUB, G. E, PIETERS, R, KAZEMIER, K. M, GÖBEL, U, KÖRHOLZ, D, GRAUBNER, U, HAAS, R. J, JORCH, N, SPAAR, H. J

“…To confirm the prognostic value of a drug resistance profile combining prednisolone, vincristine, and l-asparaginase (PVA) cytotoxicity in an independent group…”
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Hemophagocytic lymphohistiocytosis by Janka, G E

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Silencing of the tumor suppressor gene FHIT is highly characteristic for MLL gene rearranged infant acute lymphoblastic leukemia by STAM, R. W, DEN BOER, M. L, PASSIER, M. M. C. J, JANKA-SCHAUB, G. E, SALLAN, S. E, ARMSTRONG, S. A, PIETERS, R

“…MLL rearranged acute lymphoblastic leukemia (MLL) is an aggressive type of acute lymphoblastic leukemia (ALL), diagnosed predominantly in infants (<1 years of…”
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In vitro drug-resistance profile in infant acute lymphoblastic leukemia in relation to age, MLL rearrangements and immunophenotype by RAMAKERS-VAN WOERDEN, N. L, BEVERLOO, H. B, HAAS, O. A, JANKA-SCHAUB, G. E, PIETERS, R, VEERMAN, A. J. P, CAMITTA, B. M, LOONEN, A. H, VAN WERING, E. R, SLATER, R. M, HARBOTT, J, DEN BOER, M. L, LUDWIG, W. D

“…Acute lymphoblastic leukemia (ALL) in infants under 1 year is strongly associated with translocations involving 11q23 (MLL gene), CD10-negative B-lineage…”
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TEL/AML1 gene fusion is related to in vitro drug sensitivity for L-asparaginase in childhood acute lymphoblastic leukemia by WOERDEN, N. L. R.-V, PIETERS, R, HÄHLEN, K, SCHMIEGELOW, K, JANKA-SCHAUB, G. E, VEERMAN, A. J. P, LOONEN, A. H, HUBEEK, I, VAN DRUNEN, E, BEVERLOO, H. B, SLATER, R. M, HARBOTT, J, SEYFARTH, J, VAN WERING, E. R

“…The t(12;21) translocation resulting in TEL/AML1 gene fusion is present in approximately 25% of patients with precursor B-lineage pediatric acute lymphoblastic…”
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Incidence of additional genetic changes in the TEL and AML1 genes in DCOG and COALL-treated t(12;21)-positive pediatric ALL, and their relation with drug sensitivity and clinical outcome by STAMS, W. A. G, BEVERLOO, H. B, PIETERS, R, DEN BOER, M. L, DE MENEZES, R. X, STIGTER, R. L, VAN DRUNEN, E, RAMAKERS-VAN-WOERDEN, N. L, LOONEN, A. H, VAN WERING, E. R, JANKA-SCHAUB, G. E

“…Clinical heterogeneity within t(12;21) or TEL/AML1-positive ALL (25% of childhood common/preB ALL) indicates that additional genetic changes might contribute…”
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Multidrug resistance genes in infant acute lymphoblastic leukemia: Ara-C is not a substrate for the breast cancer resistance protein by STAM, R. W, VAN DEN HEUVEL-EIBRINK, M. M, DEN BOER, M. L, EBUS, M. E. G, JANKA-SCHAUB, G. E, ALLEN, J. D, PIETERS, R

“…Infants with acute lymphoblastic leukemia (ALL) are more resistant to chemotherapeutic drugs than older children with ALL, except for Ara-C. Drug resistance…”
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Relation between genetic variants of the ataxia telangiectasia-mutated ( ) gene, drug resistance, clinical outcome and predisposition to childhood T-lineage acute lymphoblastic leukaemia by MEIER, M, DEN BOER, M. L, HALL, A. G, IRVING, J. A. E, PASSIER, M, MINTO, L, VAN WERING, E. R, JANKA-SCHAUB, G. E, PIETERS, R

“…The T-lineage phenotype in children with acute lymphoblastic leukaemia (ALL) is associated with in vitro drug resistance and a higher relapse-risk compared to…”
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Differential expression of p73 isoforms in relation to drug resistance in childhood T-lineage acute lymphoblastic leukaemia by MEIER, M, DEN BOER, M. L, MEIJERINK, J. P. P, BROEKHUIS, M. J. C, PASSIER, M. M. C. J, VAN WERING, E. R, JANKA-SCHAUB, G. E, PIETERS, R

“…The T-lineage phenotype of childhood acute lymphoblastic leukaemia (ALL) is associated with an increased relapse-risk and in vitro resistance to drugs as…”
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Liver iron stores in patients with secondary haemosiderosis under iron chelation therapy with deferoxamine or deferiprone by Nielsen, P, Fischer, R, Engelhardt, R, Tondüry, P, Gabbe, E E, Janka, G E

“…Total body iron stores including liver and spleen iron were assessed by non-invasive SQUID biomagnetometry. The liver iron concentration was measured in groups…”
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Cell proliferation is related to in vitro drug resistance in childhood acute leukaemia by KAAIJK, P, KASPERS, G. J. L, VEERMAN, A. J. P, VAN WERING, E. R, BROEKEMA, G. J, LOONEN, A. H, HÄHLEN, K, SCHMIEGELOW, K, JANKA-SCHAUB, G. E, HENZE, G, CREUTZIG, U

“…Bone marrow and peripheral blood samples from 362 patients with acute lymphoblastic leukaemia (ALL) proliferating cell and 90 patients with acute myeloid…”
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Relationship between the intracellular daunorubicin concentration, expression of major vault protein/lung resistance protein and resistance to anthracyclines in childhood acute lymphoblastic leukemia by BOER, M. L. D, PIETERS, R, KAZEMIER, K. M, JANKA-SCHAUB, G. E, HENZE, G, VEERMAN, A. J. P

“…In vitro resistance to anthracyclines is related to a poor prognosis in childhood acute lymphoblastic leukemia (ALL), but the underlying mechanisms are poorly…”
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Visceral leishmaniasis triggering (mimicking) macrophage activation syndrome in a patient with adult onset Still disease by Barešić, M., Janka, G. E., Gjadrov-Kuveždić, K., Zekan, Š., Anić, B.

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Myeloid antigen co‐expression in childhood acute lymphoblastic leukaemia: relationship with in vitro drug resistance by Den Boer, M. L., Kapaun, P., Pieters, R., Kazemier, K. M., Janka‐Schaub, G. E., Veerman, A. J. P.

“…Contradictory data have been reported about the prognostic value of myeloid antigen co‐expression (My+) in childhood acute lymphoblastic leukaemia (ALL). In…”
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Familial hemophagocytic lymphohistiocytosis by Janka, G E

“…Familial hemophagocytic lymphohistiocytosis (FHL) is probably a genetically transmitted disease affecting infants and very young children. Cardinal symptoms…”
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The modulating effect of PSC 833, cyclosporin a, verapamil and genistein on in vitro cytotoxicity and intracellular content of daunorubicin in childhood acute lymphoblastic leukemia by DEN BOER, M. L, PIETERS, R, KAZEMIER, K. M, JANKA-SCHAUB, G. E, HENZE, G, VEERMAN, A. J. P

“…Resistance to anthracyclines is related to a poor prognosis in childhood acute lymphoblastic leukemia (ALL). Resistance to this class of drugs may (partly) be…”
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Different expression of glutathione S‐transferase α, μ and π in childhood acute lymphoblastic and myeloid leukaemia by Den Boer, M. L., Pieters, R., Kazemier, K. M., Janka‐Schaub, G. E., Henze, G., Creutzig, U., Kaspers, G. J. L., Kearns, P. R., Hall, A. G., Pearson, A. D. J., Veerman, A. J. P.

“…Expression of three major classes of glutathione S‐transferases (GSTs), i.e. α, μ and π class, P‐glycoprotein (P‐gp) and multidrug resistance‐associated…”
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