Search Results - "Janjic, Nebojsa"

Embracing proteins: structural themes in aptamer–protein complexes by Gelinas, Amy D, Davies, Douglas R, Janjic, Nebojsa

“…•Traditional aptamers fold into structures with established nucleic acid motifs.•Modified nucleotides expand the repertoire of known nucleic acid structural…”
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Nucleic Acid Ligands With Protein-like Side Chains: Modified Aptamers and Their Use as Diagnostic and Therapeutic Agents by Rohloff, John C, Gelinas, Amy D, Jarvis, Thale C, Ochsner, Urs A, Schneider, Daniel J, Gold, Larry, Janjic, Nebojsa

“…Limited chemical diversity of nucleic acid libraries has long been suspected to be a major constraining factor in the overall success of SELEX (Systematic…”
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Structural basis for IL-1α recognition by a modified DNA aptamer that specifically inhibits IL-1α signaling by Ren, Xiaoming, Gelinas, Amy D., von Carlowitz, Ira, Janjic, Nebojsa, Pyle, Anna Marie

“…IL-1α is an essential cytokine that contributes to inflammatory responses and is implicated in various forms of pathogenesis and cancer. Here we report a…”
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Structural model of the dimeric Parkinson’s protein LRRK2 reveals a compact architecture involving distant interdomain contacts by Guaitoli, Giambattista, Raimondi, Francesco, Gilsbach, Bernd K., Gómez-Llorente, Yacob, Deyaert, Egon, Renzi, Fabiana, Li, Xianting, Schaffner, Adam, Jagtap, Pravin Kumar Ankush, Boldt, Karsten, von Zweydorf, Felix, Gotthardt, Katja, Lorimer, Donald D., Yue, Zhenyu, Burgin, Alex, Janjic, Nebojsa, Sattler, Michael, Versées, Wim, Ueffing, Marius, Ubarretxena-Belandia, Iban, Kortholt, Arjan, Gloeckner, Christian Johannes

“…Leucine-rich repeat kinase 2 (LRRK2) is a large, multidomain protein containing two catalytic domains: a Ras of complex proteins (Roc) G-domain and a kinase…”
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Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study by Penn-Nicholson, Adam, Hraha, Thomas, Thompson, Ethan G, Sterling, David, Mbandi, Stanley Kimbung, Wall, Kirsten M, Fisher, Michelle, Suliman, Sara, Shankar, Smitha, Hanekom, Willem A, Janjic, Nebojsa, Hatherill, Mark, Kaufmann, Stefan H E, Sutherland, Jayne, Walzl, Gerhard, De Groote, Mary Ann, Ochsner, Urs, Zak, Daniel E, Scriba, Thomas J

“…A nonsputum blood test capable of predicting progression of healthy individuals to active tuberculosis (TB) before clinical symptoms manifest would allow…”
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Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets by Davies, Douglas R, Gelinas, Amy D, Zhang, Chi, Rohloff, John C, Carter, Jeffrey D, O’Connell, Daniel, Waugh, Sheela M, Wolk, Steven K, Mayfield, Wesley S, Burgin, Alex B, Edwards, Thomas E, Stewart, Lance J, Gold, Larry, Janjic, Nebojsa, Jarvis, Thale C

“…Selection of aptamers from nucleic acid libraries by in vitro evolution represents a powerful method of identifying high-affinity ligands for a broad range of…”
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Elucidating novel serum biomarkers associated with pulmonary tuberculosis treatment by De Groote, Mary A, Nahid, Payam, Jarlsberg, Leah, Johnson, John L, Weiner, Marc, Muzanyi, Grace, Janjic, Nebojsa, Sterling, David G, Ochsner, Urs A

“…In an unbiased approach to biomarker discovery, we applied a highly multiplexed proteomic technology (SOMAscan, SomaLogic, Inc, Boulder, CO) to understand…”
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Systematic selection of modified aptamer pairs for diagnostic sandwich assays by Ochsner, Urs A, Green, Louis S, Gold, Larry, Janjic, Nebojsa

“…Protein diagnostic applications typically require pairs of analyte-specific reagents for capture and detection. We developed methods for the systematic…”
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Single-Molecule Super-Resolution Microscopy Reveals Heteromeric Complexes of MET and EGFR upon Ligand Activation by Harwardt, Marie-Lena I E, Schröder, Mark S, Li, Yunqing, Malkusch, Sebastian, Freund, Petra, Gupta, Shashi, Janjic, Nebojsa, Strauss, Sebastian, Jungmann, Ralf, Dietz, Marina S, Heilemann, Mike

“…Receptor tyrosine kinases (RTKs) orchestrate cell motility and differentiation. Deregulated RTKs may promote cancer and are prime targets for specific…”
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Highly Multiplexed Proteomic Analysis of Quantiferon Supernatants To Identify Biomarkers of Latent Tuberculosis Infection by De Groote, Mary Ann, Higgins, Michael, Hraha, Thomas, Wall, Kirsten, Wilson, Michael L, Sterling, David G, Janjic, Nebojsa, Reves, Randall, Ochsner, Urs A, Belknap, Robert

“…The tests for diagnosing latent tuberculosis infection (LTBI) are limited by a poor predictive value for identifying people at the highest risk for progressing…”
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Plasma proteome of growing tumors by Gupta, Shashi, Westacott, Matthew J., Ayers, Deborah G., Weiss, Sophie J., Whitley, Penn, Mueller, Christopher, Weaver, Daniel C., Schneider, Daniel J., Karimpour-Fard, Anis, Hunter, Lawrence E., Drolet, Daniel W., Janjic, Nebojsa

“…Early detection of cancer is vital for the best chance of successful treatment, but half of all cancers are diagnosed at an advanced stage. A simple and…”
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Protein signature of lung cancer tissues by Mehan, Michael R, Ayers, Deborah, Thirstrup, Derek, Xiong, Wei, Ostroff, Rachel M, Brody, Edward N, Walker, Jeffrey J, Gold, Larry, Jarvis, Thale C, Janjic, Nebojsa, Baird, Geoffrey S, Wilcox, Sheri K

“…Lung cancer remains the most common cause of cancer-related mortality. We applied a highly multiplexed proteomic technology (SOMAscan) to compare protein…”
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Broadly neutralizing aptamers to SARS-CoV-2: A diverse panel of modified DNA antiviral agents by Gelinas, Amy D., Tan, Tiong Kit, Liu, Sai, Jaramillo, Javier G., Chadwick, James, Harding, Adam C., Zhang, Chi, Ream, Brian E., Chase, Chelsea N., Otis, Matthew R., Lee, Thomas, Schneider, Daniel J., James, William S., Janjic, Nebojsa

“…Since its discovery, COVID-19 has rapidly spread across the globe and has had a massive toll on human health, with infection mortality rates as high as 10%,…”
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Aptamer-based proteomic signature of intensive phase treatment response in pulmonary tuberculosis by Nahid, Payam, Bliven-Sizemore, Erin, Jarlsberg, Leah G, De Groote, Mary A, Johnson, John L, Muzanyi, Grace, Engle, Melissa, Weiner, Marc, Janjic, Nebojsa, Sterling, David G, Ochsner, Urs A

“…Summary Background New drug regimens of greater efficacy and shorter duration are needed for tuberculosis (TB) treatment. The identification of accurate,…”
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The Role of COVID-19-Associated Fear, Stress and Level of Social Support in Development of Suicidality in Patients Diagnosed with Affective and Stress-Induced Psychiatric Disorders during the COVID-19 Pandemic-A Comparative Analysis by Kuljancic, Dusan, Cvjetkovic Bosnjak, Mina, Siladji, Djendji, Hinic, Darko, Veskovic, Dunja, Janjic, Nebojsa, Ratkovic, Dragana, Zivanovic, Olga, Vasic, Vesna, Sakic, Branislav

“…Only a few studies seem to address suicidality as an effect of the COVID-19 pandemic in persons previously affected by psychiatric disorders. The relationship…”
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Correction: Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study by Penn-Nicholson, Adam, Hraha, Thomas, Thompson, Ethan G, Sterling, David, Mbandi, Stanley Kimbung, Wall, Kirsten M, Fisher, Michelle, Suliman, Sara, Shankar, Smitha, Hanekom, Willem A, Janjic, Nebojsa, Hatherill, Mark, Kaufmann, Stefan H E, Sutherland, Jayne, Walzl, Gerhard, De Groote, Mary Ann, Ochsner, Urs, Zak, Daniel E, Scriba, Thomas J

“…[This corrects the article DOI: 10.1371/journal.pmed.1002781.]…”
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Structure of PolC reveals unique DNA binding and fidelity determinants by Evans, Ronald J, Davies, Douglas R, Bullard, James M, Christensen, Jeffrey, Green, Louis S, Guiles, Joseph W, Pata, Janice D, Ribble, Wendy K, Janjic, Nebojsa, Jarvis, Thale C

“…PolC is the polymerase responsible for genome duplication in many Gram-positive bacteria and represents an attractive target for antibacterial development. We…”
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National and Regional Assessment of Antimicrobial Resistance among Community-Acquired Respiratory Tract Pathogens Identified in a 2005-2006 U.S. Faropenem Surveillance Study by CRITCHLEY, Ian A, BROWN, Steven D, TRACZEWSKI, Maria M, TILLOTSON, Glenn S, JANJIC, Nebojsa

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Discovery and Analysis of 4H-Pyridopyrimidines, a Class of Selective Bacterial Protein Synthesis Inhibitors by RIBBLE, Wendy, HILL, Walter E, OCHSNER, Urs A, JARVIS, Thale C, GUILES, Joseph W, JANJIC, Nebojsa, BULLARD, James M

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Inhibition of Methionyl-tRNA Synthetase by REP8839 and Effects of Resistance Mutations on Enzyme Activity by GREEN, Louis S, BULLARD, James M, RIBBLE, Wendy, DEAN, Frank, AYERS, David F, OCHSNER, Urs A, JANJIC, Nebojsa, JARVIS, Thale C

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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