Search Results - "Janis, Gregory C"

The Fentanyl Epidemic and Evolution of Fentanyl Analogs in the United States and the European Union by Jannetto, Paul J, Helander, Anders, Garg, Uttam, Janis, Gregory C, Goldberger, Bruce, Ketha, Hemamalini

“…Since 2013, an unprecedented surge in fentanyl overdose deaths has been caused by heroin laced with illicitly produced fentanyl and/or fentanyl analogs (FAs)…”
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Identification of Unique Metabolites of the Designer Opioid Furanyl Fentanyl by Goggin, Melissa M, Nguyen, An, Janis, Gregory C

“…The illicit drug market has seen an increase in designer opioids, including fentanyl and methadone analogs, and other structurally unrelated opioid agonists…”
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Analysis of Synthetic Cannabinoid Metabolites by Liquid Chromatography-Tandem Mass Spectrometry by Janis, Gregory C

“…The analysis of synthetic cannabinoid compounds in a urine sample is currently one of the more complex tasks facing toxicologists. The list of prevalent…”
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A randomized trial comparing physostigmine vs lorazepam for treatment of antimuscarinic (anticholinergic) toxidrome by Wang, George Sam, Baker, Keith, Ng, Patrick, Janis, Gregory C., Leonard, Jan, Mistry, Rakesh D., Heard, Kennon

“…Toxicity from antimuscarinic agents precipitates a constellation of signs and symptoms; two of the most significant are agitation and delirium. Benzodiazepines…”
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Using measured cannabidiol and tetrahydrocannabinol metabolites in urine to differentiate marijuana use from consumption of commercial cannabidiol products by Goggin, Melissa M., Janis, Gregory C.

“…Detecting marijuana use is a component of most urine drug screens targeting a single Δ 9 -tetrahydrocannabinol metabolite. Recently, the non-intoxicating…”
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A case of U-47700 overdose with laboratory confirmation and metabolite identification by Jones, Matthew J., Hernandez, Bradley S., Janis, Gregory C., Stellpflug, Samuel J.

“…Context: The opioid epidemic has included use of traditional drugs and recently newer synthetics. It is critically important to recognize and identify these…”
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Salt-Assisted Liquid-Liquid Extraction of Meconium for Analysis of Cocaine and Amphetamines by Liquid Chromatography-Tandem Mass Spectrometry by Goggin, Melissa M, Janis, Gregory C

“…Meconium, the first stool of a newborn, can be analyzed to identify prenatal exposure to drugs of abuse. Meconium accumulates in a fetus during the second and…”
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2-(4-Iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine (25I-NBOMe): Clinical Case with Unique Confirmatory Testing by Stellpflug, Samuel J., Kealey, Samantha E., Hegarty, Cullen B., Janis, Gregory C.

“…Introduction 2C designer drugs have been in use since the 1970s, but new drugs continue to develop from substitutions to the base phenethylamine structure…”
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Analysis of Mitragynine and Metabolites in Human Urine for Detecting the Use of the Psychoactive Plant Kratom by Le, David, Goggin, Melissa M., Janis, Gregory C.

“…The leaves of the South Asian plant kratom are described as having stimulating effects at low doses, and opiate-like analgesic and euphoric effects at high…”
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Catching Fakes: New Markers of Urine Sample Validity and Invalidity by Goggin, Melissa M, Tann, Cheng-Min, Miller, Anna, Nguyen, An, Janis, Gregory C

“…Urine drug testing is common for workplace drug testing, prescription management, emergency medicine and the criminal justice system. Unsurprisingly, with the…”
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Anodyne by Design; Measuring the Prevalence of Esoteric Designer Opioids in Pain Management Patients by Goggin, Melissa M, Gozum, Stephanie D, Miller, Anna, Janis, Gregory C

“…Abstract The recent increase in illicit opioids sold on the black market, cut into heroin and masqueraded as prescription pills prompts a significant public…”
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Profiting from Probability; Combining Low and High Probability Isotopes as a Tool Extending the Dynamic Range of an Assay Measuring Amphetamine and Methamphetamine in Urine by Miller, Anna M, Goggin, Melissa M, Nguyen, An, Gozum, Stephanie D, Janis, Gregory C

“…A wide range of concentrations are frequently observed when measuring drugs of abuse in urine toxicology samples; this is especially true for amphetamine and…”
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Reduced urinary opioid levels from pain management patients associated with marijuana use by Goggin, Melissa M, Shahriar, Breane J, Stead, Andy, Janis, Gregory C

“…Marijuana use has been postulated to modulate opioid use, dependence and withdrawal. Broad target drug testing results provide a unique perspective to identify…”
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“Retention Projection” Enables Reliable Use of Shared Gas Chromatographic Retention Data Across Laboratories, Instruments, and Methods by Barnes, Brian B, Wilson, Michael B, Carr, Peter W, Vitha, Mark F, Broeckling, Corey D, Heuberger, Adam L, Prenni, Jessica, Janis, Gregory C, Corcoran, Henry, Snow, Nicholas H, Chopra, Shilpi, Dhandapani, Ramkumar, Tawfall, Amanda, Sumner, Lloyd W, Boswell, Paul G

“…Gas chromatography/mass spectrometry (GC/MS) is a primary tool used to identify compounds in complex samples. Both mass spectra and GC retention times are…”
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Analysis of selected anticonvulsants by high performance liquid chromatography-tandem mass spectrometry by Collins, Jennifer A, Janis, Gregory C

“…A method for the analysis of the basic antiepileptic compounds felbamate, lamotrigine, carbamazepine, carbamazepine-10,11-epoxide, gabapentin, pregabalin,…”
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Neurosteroids Mediate Pharmacological Effects of Ethanol: A New Mechanism of Ethanol Action? by Morrow, A. Leslie, Janis, Gregory C., VanDoren, Margaret J., Matthews, Douglas B., Samson, Herman H., Janak, Patricia H., Grant, Kathleen A.

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Analysis of total and transferrin-bound iron in human serum for pharmacokinetic studies of iron-sucrose formulations by Goggin, Melissa M, Gozum, Stephanie D, Burrows, David M, Nguyen, An, Corcoran, Henry F, Dotzauer, Heather, Tann, Cheng-Min, Lundberg, Richard A, Janis, Gregory C

“…Patients with iron-deficiency anemia benefit from intravenous iron therapies. Development of these pharmaceutical agents requires pharmacokinetic studies…”
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Neuroactive Steroid 3α-Hydroxy-5α-Pregnan-20-One Modulates Electrophysiological and Behavioral Actions of Ethanol by VanDoren, Margaret J., Matthews, Douglas B., Janis, Gregory C., Grobin, A. Chistina, Devaud, Leslie L., Morrow, A. Leslie

“…Neuroactive steroids are synthesized de novo in brain, yet their physiological significance remains elusive. We provide biochemical, electrophysiological, and…”
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“Retention Projection” Enables Reliable Use of Shared Gas Chromatographic Retention Data Across Labs, Instruments, and Methods by Barnes, Brian B., Wilson, Michael B., Carr, Peter W., Vitha, Mark F., Broeckling, Corey D., Heuberger, Adam L., Prenni, Jessica, Janis, Gregory C., Corcoran, Henry, Snow, Nicholas H., Chopra, Shilpi, Dhandapani, Ramkumar, Tawfall, Amanda, Sumner, Lloyd W., Boswell, Paul G.

“…Gas chromatography-mass spectrometry (GC-MS) is a primary tool used to identify compounds in complex samples. Both mass spectra and GC retention times are…”
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Effects of Chronic Ethanol Consumption and Withdrawal on the Neuroactive Steroid 3α-Hydroxy-5α-pregnan-20-one in Male and Female Rats by Janis, Gregory C., Devaud, Leslie L., Mitsuyama, Hiroki, Morrow, A. Leslie

“…Prolonged alcohol (ethanol) consumption leads to the development of alcohol tolerance and cross‐tolerance to some benzodiazepines and barbiturates. In…”
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