Search Results - "Janin, Yves"

Preparation and Chemistry of 3/5-Halogenopyrazoles by Janin, Yves L

“…A study investigated the chemistry and preparation of 3/5-halogenopyrazoles and discusses the lack of interest in academia with heteroclyclic chemistry…”
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Antituberculosis drugs: Ten years of research by Janin, Yves L.

“…Death of Frédéric Chopin; 1810–1849 (after a painting of Félix Barrias; Bibliothèque Nationale de France;…”
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Non-quinolone Inhibitors of Bacterial Type IIA Topoisomerases: A Feat of Bioisosterism by Mayer, Claudine, Janin, Yves L

“…Mayer and Janin examine non-quinolone inhibitors of bacterial type IIA topoisomerases with regard to bioisosterism…”
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Deciphering Enzyme Mechanisms with Engineered Ancestors and Substrate Analogues by Gao, Tadeja, Damborsky, Jiri, Janin, Yves L., Marek, Martin

“…Environmentally friendly industrial and biotech processes greatly benefit from enzyme‐based technologies. Their use is often possible only when the…”
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Bioluminescence Profiling of NanoKAZ/NanoLuc Luciferase Using a Chemical Library of Coelenterazine Analogues by Coutant, Eloi P., Gagnot, Glwadys, Hervin, Vincent, Baatallah, Racha, Goyard, Sophie, Jacob, Yves, Rose, Thierry, Janin, Yves L.

“…We describe here an extensive structure‐bioluminescence relationship study of a chemical library of analogues of coelenterazine, using nanoKAZ/NanoLuc, a…”
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On Dihydroorotate Dehydrogenases and Their Inhibitors and Uses by Munier-Lehmann, Hélène, Vidalain, Pierre-Olivier, Tangy, Frédéric, Janin, Yves L

“…Proper nucleosides availability is crucial for the proliferation of living entities (eukaryotic cells, parasites, bacteria, and virus). Accordingly, the uses…”
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ATPase inhibitors of heat-shock protein 90, second season by Janin, Yves L.

“…In the past four years, the ATP-dependent heat-shock protein 90 has remained the focus of much interest. Phase I and phase II anticancer clinical trials with…”
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On Reuben G. Jones synthesis of 2-hydroxypyrazines by Legrand, Pierre, Janin, Yves L

“…In 1949, Reuben G. Jones disclosed an original synthesis of 2-hydroxypyrazines involving a double condensation between 1,2-dicarbonyls and α-aminoamides upon…”
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On drug discovery against infectious diseases and academic medicinal chemistry contributions by Janin, Yves L

“…This perspective is an attempt to document the problems that medicinal chemists are facing in drug discovery. It is also trying to identify relevant/possible,…”
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Synthetic Routes to Coelenterazine and Other Imidazo[1,2-a]pyrazin-3-one Luciferins: Essential Tools for Bioluminescence-Based Investigations by Coutant, Eloi P., Janin, Yves L.

“…In the last few decades, bioluminescent systems based on the expression of a luciferase and the addition of a luciferin to monitor the emission of light have…”
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Gram-scale synthesis of luciferins derived from coelenterazine and original insights into their bioluminescence properties by Coutant, Eloi P, Goyard, Sophie, Hervin, Vincent, Gagnot, Glwadys, Baatallah, Racha, Jacob, Yves, Rose, Thierry, Janin, Yves L

“…An original gram-scale synthesis of O-acetylated forms of coelenterazine, furimazine or hydroxy-bearing analogues of luciferins is described. The comparison…”
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Maximizing binary interactome mapping with a minimal number of assays by Choi, Soon Gang, Olivet, Julien, Cassonnet, Patricia, Vidalain, Pierre-Olivier, Luck, Katja, Lambourne, Luke, Spirohn, Kerstin, Lemmens, Irma, Dos Santos, Mélanie, Demeret, Caroline, Jones, Louis, Rangarajan, Sudharshan, Bian, Wenting, Coutant, Eloi P., Janin, Yves L., van der Werf, Sylvie, Trepte, Philipp, Wanker, Erich E., De Las Rivas, Javier, Tavernier, Jan, Twizere, Jean-Claude, Hao, Tong, Hill, David E., Vidal, Marc, Calderwood, Michael A., Jacob, Yves

“…Complementary assays are required to comprehensively map complex biological entities such as genomes, proteomes and interactome networks. However, how various…”
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Core‐Modified Coelenterazine Luciferin Analogues: Synthesis and Chemiluminescence Properties by Gagnot, Glwadys, Hervin, Vincent, Coutant, Eloi P., Goyard, Sophie, Jacob, Yves, Rose, Thierry, Hibti, Fatima Ezzahra, Quatela, Alessia, Janin, Yves L.

“…In this work on the design and studies of luciferins related to the blue‐hued coelenterazine, the synthesis of heterocyclic analogues susceptible to produce a…”
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5-Iodo-3-Ethoxypyrazoles: An Entry Point to New Chemical Entities by Guillou, Sandrine, Janin, Yves L.

“…Our program, which has focused on the preparation of new pyrazole derivatives, has led us to report here an original and simplified preparation of ethyl…”
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Measuring the subcellular compartmentalization of viral infections by protein complementation assay by Fernandez, Juliette, Hassen-Khodja, Cédric, Georget, Virginie, Rose, Thierry, Jacob, Yves, Janin, Yves L., Nisole, Sébastien, Vidalain, Pierre-Olivier, Arhel, Nathalie J.

“…The recent emergence and reemergence of viruses in the human population has highlighted the need to develop broader panels of therapeutic molecules…”
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A highly sensitive bioluminescent method for measuring allergen‐specific IgE in microliter samples by Goyard, Sophie, Balbino, Bianca, Chinthrajah, Rebecca S., Lyu, Shu‐Chen, Janin, Yves L., Bruhns, Pierre, Poncet, Pascal, Galli, Stephen J., Nadeau, Kari C., Reber, Laurent L., Rose, Thierry

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Illuminating the mechanism and allosteric behavior of NanoLuc luciferase by Nemergut, Michal, Pluskal, Daniel, Horackova, Jana, Sustrova, Tereza, Tulis, Jan, Barta, Tomas, Baatallah, Racha, Gagnot, Glwadys, Novakova, Veronika, Majerova, Marika, Sedlackova, Karolina, Marques, Sérgio M., Toul, Martin, Damborsky, Jiri, Prokop, Zbynek, Bednar, David, Janin, Yves L., Marek, Martin

“…NanoLuc, a superior β-barrel fold luciferase, was engineered 10 years ago but the nature of its catalysis remains puzzling. Here experimental and computational…”
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Original 2‑(3-Alkoxy‑1H‑pyrazol-1-yl)pyrimidine Derivatives as Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH) by Munier-Lehmann, Hélène, Lucas-Hourani, Marianne, Guillou, Sandrine, Helynck, Olivier, Zanghi, Gigliola, Noel, Anne, Tangy, Frédéric, Vidalain, Pierre-Olivier, Janin, Yves L

“…From a research program aimed at the design of new chemical entities followed by extensive screening on various models of infectious diseases, an original…”
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High seroprevalence but short‐lived immune response to SARS‐CoV‐2 infection in Paris by Anna, François, Goyard, Sophie, Lalanne, Ana Ines, Nevo, Fabien, Gransagne, Marion, Souque, Philippe, Louis, Delphine, Gillon, Véronique, Turbiez, Isabelle, Bidard, François‐Clément, Gobillion, Aline, Savignoni, Alexia, Guillot‐Delost, Maude, Dejardin, François, Dufour, Evelyne, Petres, Stéphane, Richard‐Le Goff, Odile, Choucha, Zaineb, Helynck, Olivier, Janin, Yves L., Escriou, Nicolas, Charneau, Pierre, Perez, Franck, Rose, Thierry, Lantz, Olivier

“…Although the COVID‐19 pandemic peaked in March/April 2020 in France, the prevalence of infection is barely known. Using high‐throughput methods, we assessed…”
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Biophysical analysis of Gaussia luciferase bioluminescence mechanisms using a non-oxidizable coelenterazine by Takatsu, Kyoko, Kobayashi, Naohiro, Wu, Nan, Janin, Yves L., Yamazaki, Toshio, Kuroda, Yutaka

“…•Gaussia luciferase emits a bright blue light when oxidizing coelenterazine (CTZ).•A non-oxidizable coelenterazine (Aza-CTZ) wnabled investigation of Gluc's…”
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