Search Results - "Janicot, Michel"

First-in-human phase I study of ISTH0036, an antisense oligonucleotide selectively targeting transforming growth factor beta 2 (TGF-β2), in subjects with open-angle glaucoma undergoing glaucoma filtration surgery by Pfeiffer, Norbert, Voykov, Bogomil, Renieri, Giulia, Bell, Katharina, Richter, Paul, Weigel, Melanie, Thieme, Hagen, Wilhelm, Barbara, Lorenz, Katrin, Feindor, Martin, Wosikowski, Katja, Janicot, Michel, Päckert, Daniela, Römmich, Regina, Mala, Carola, Fettes, Petra, Leo, Eugen

“…To evaluate the safety and tolerability of intravitreal ISTH0036, an antisense oligonucleotide selectively targeting transforming growth factor beta 2…”
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JNJ-26481585, a Novel “Second-Generation” Oral Histone Deacetylase Inhibitor, Shows Broad-Spectrum Preclinical Antitumoral Activity by Arts, Janine, King, Peter, Mariën, Ann, Floren, Wim, Beliën, Ann, Janssen, Lut, Pilatte, Isabelle, Roux, Bruno, Decrane, Laurence, Gilissen, Ron, Hickson, Ian, Vreys, Veronique, Cox, Eugene, Bol, Kees, Talloen, Willem, Goris, Ilse, Andries, Luc, Du Jardin, Marc, Janicot, Michel, Page, Martin, van Emelen, Kristof, Angibaud, Patrick

“…Purpose: Histone deacetylase (HDAC) inhibitors have shown promising clinical activity in the treatment of hematologic malignancies, but their activity in solid…”
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Safety evaluation of long-term temperature controlled whole-body thermal treatment in female Aachen minipig by Carneiro, Marcia Weber, Brancato, Luigi, Wylleman, Britta, van Zwol, Eke, Conings, Liesbet, Vueghs, Peter, Gorbaslieva, Ivana, Van den Bossche, Johan, Rudenko, Oleg, Janicot, Michel, Bogers, John-Paul

“…Objective: Thermal treatment (TT), defined as treatment using supra-physiological body temperatures (39-45 C), somewhat resembles fever in terms of temperature…”
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Biological Role and Therapeutic Targeting of TGF-β3 in Glioblastoma by Seystahl, Katharina, Papachristodoulou, Alexandros, Burghardt, Isabel, Schneider, Hannah, Hasenbach, Kathy, Janicot, Michel, Roth, Patrick, Weller, Michael

“…Abstract Transforming growth factor (TGF)-β contributes to the malignant phenotype of glioblastoma by promoting invasiveness and angiogenesis and creating an…”
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Transcriptome-wide analysis reveals insight into tumor suppressor functions of 1B3, a novel synthetic miR-193a-3p mimic by van den Bosch, Marion T.J., Yahyanejad, Sanaz, Alemdehy, Mir Farshid, Telford, Bryony J., de Gunst, Thijs, den Boer, Harm C., Vos, Rogier M., Stegink, Marieke, van Pinxteren, Laurens A.H., Schaapveld, Roel Q.J., Janicot, Michel

“…Emerging data show that microRNA 193a-3p (miR-193a-3p) has a suppressive role in many cancers and is often downregulated in tumors, as compared to surrounding…”
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The tumor suppressor 5A2, a synthetic miR-7-5p mimic, targets oncogenic and metabolic pathways, as revealed by transcriptome-wide analysis by van den Bosch, Marion T. J., Telford, Bryony J., Yahyanejad, Sanaz, de Gunst, Thijs, den Boer, Harm C., Vos, Rogier M., Duurland, Chantal L., Biemans, Rianne, Dubois, Ludwig J., van Pinxteren, Laurens A. H., Schaapveld, Roel Q. J., Janicot, Michel

“…As cancer is a multifactorial disease, the multimodal action of microRNAs makes them an attractive tool for novel therapeutic approaches. The tumor suppressive…”
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Disruption of Murine Mus81 Increases Genomic Instability and DNA Damage Sensitivity but Does Not Promote Tumorigenesis by Dendouga, Najoua, Gao, Hui, Moechars, Dieder, Janicot, Michel, Vialard, Jorge, McGowan, Clare H.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Critical role of the ubiquitin ligase activity of UHRF1, a nuclear RING finger protein, in tumor cell growth by Jenkins, Yonchu, Markovtsov, Vadim, Lang, Wayne, Sharma, Poonam, Pearsall, Denise, Warner, Justin, Franci, Christian, Huang, Betty, Huang, Jianing, Yam, George C, Vistan, Joseph P, Pali, Erlina, Vialard, Jorge, Janicot, Michel, Lorens, James B, Payan, Donald G, Hitoshi, Yasumichi

“…Early cellular events associated with tumorigenesis often include loss of cell cycle checkpoints or alteration in growth signaling pathways. Identification of…”
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P422: TARGETING THE WT1MUT‐MIR‐193A TRANSCRIPTIONAL AXIS WITH INT‐1B3, A NOVEL LIPID NANOPARTICLE‐FORMULATED MIR‐193A‐3P MIMIC IN ACUTE MYELOID LEUKEMIA by Yang, Xining, Krowiorz, Kathrin, Buelow, Daelynn, Bhayadia, Raj, Kohlschmidt, Jessica, Nicolet, Deedra, Maetzig, Tobias, Pabst, Caroline, Hui, Jeremy, Shad, Arshia, Gao, Sharon, Stephenson, Maria, Wei Wu, Si, Bosch, Marion, Escano, Leo, Lock, Frances, Panahi, Afsaneh, Macphee, Liam, Maksakova, Irina, Amoah, Amanda, Döhner, Konstanze, Fogelstrand, Linda, Eisfeld, Ann‐Kathrin, Yahyanejad, Sanaz, Janicot, Michel, Klusmann, Jan‐Henning, Baker, Sharyn, Oakes, Christopher, Rouhi, Arefeh, Kuchenbauer, Florian

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Targeted delivery of RNA-cleaving DNA enzyme (DNAzyme) to tumor tissue by transferrin-modified, cyclodextrin-based particles by Pun, Suzie H., Tack, Frederik, Bellocq, Nathalie C., Cheng, Jianjun, Grubbs, Brendan H., Jensen, Gregory S., Davis, Mark E., Brewster, Marcus, Janicot, Michel, Janssens, Boudewijn, Floren, Wim, Bakker, Annette

“…Short nucleic acid sequences specific to oncogene targets such as bcl-2, bcr-abl, and c-myc have been shown to exhibit specific anti-cancer activity in vitro…”
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Inhibition of histone deacetylases by chlamydocin induces apoptosis and proteasome-mediated degradation of survivin by De Schepper, Stefanie, Bruwiere, Hélène, Verhulst, Tinne, Steller, Ulf, Andries, Luc, Wouters, Walter, Janicot, Michel, Arts, Janine, Van Heusden, Jim

“…The naturally occurring cyclic tetrapeptide chlamydocin is a very potent inhibitor of cell proliferation. Here we show that chlamydocin is a highly potent…”
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Therapeutic Targeting of TGFβ Ligands in Glioblastoma Using Novel Antisense Oligonucleotides Reduces the Growth of Experimental Gliomas by Papachristodoulou, Alexandros, Silginer, Manuela, Weller, Michael, Schneider, Hannah, Hasenbach, Kathy, Janicot, Michel, Roth, Patrick

“…Transforming growth factor (TGF)-β is expressed at high levels by glioma cells and contributes to the malignant phenotype of glioblastoma. However, its…”
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Real-time gene expression analysis in human xenografts for evaluation of histone deacetylase inhibitors by Beliën, Ann, De Schepper, Stefanie, Floren, Wim, Janssens, Boud, Mariën, Ann, King, Peter, Van Dun, Jacky, Andries, Luc, Voeten, Jan, Bijnens, Luc, Janicot, Michel, Arts, Janine

“…Real-time analysis of gene expression in experimental tumor models represents a major tool to document disease biology and evaluate disease treatment. However,…”
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Design and Selection of Antisense Oligonucleotides Targeting Transforming Growth Factor Beta (TGF-β) Isoform mRNAs for the Treatment of Solid Tumors by Jaschinski, Frank, Korhonen, Hanna, Janicot, Michel

“…Transforming growth factor beta isoforms (TGF-β1, -β2, and -β3) are cytokines associated with a wide range of biological processes in oncology including tumor…”
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p53-Independent Regulation of p21Waf1/Cip1 Expression and Senescence by Chk2 by Aliouat-Denis, Cécile-Marie, Dendouga, Najoua, Van den Wyngaert, Ilse, Goehlmann, Hinrich, Steller, Ulf, van de Weyer, Inez, Van Slycken, Nele, Andries, Luc, Kass, Stefan, Luyten, Walter, Janicot, Michel, Vialard, Jorge E

“…The Chk2 kinase is a tumor suppressor and key component of the DNA damage checkpoint response that encompasses cell cycle arrest, apoptosis, and DNA repair. It…”
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R176502, a new bafilolide metabolite with potent antiproliferative activity from a novel Micromonospora species by Laakso, Jodi A, Mocek, Ursula M, Van Dun, Jacky, Wouters, Walter, Janicot, Michel

“…During the course of a screening program intended to identify new antiproliferative agents, a new bafilolide metabolite was discovered. R176502 (1) was…”
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TGF-β2 silencing to target biliary-derived liver diseases by Dropmann, Anne, Dooley, Steven, Dewidar, Bedair, Hammad, Seddik, Dediulia, Tatjana, Werle, Julia, Hartwig, Vanessa, Ghafoory, Shahrouz, Woelfl, Stefan, Korhonen, Hanna, Janicot, Michel, Wosikowski, Katja, Itzel, Timo, Teufel, Andreas, Schuppan, Detlef, Stojanovic, Ana, Cerwenka, Adelheid, Nittka, Stefanie, Piiper, Albrecht, Gaiser, Timo, Beraza, Naiara, Milkiewicz, Malgorzata, Milkiewicz, Piotr, Brain, John G, Jones, David E J, Weiss, Thomas S, Zanger, Ulrich M, Ebert, Matthias, Meindl-Beinker, Nadja M

“…TGF-β2 (TGF-β, transforming growth factor beta), the less-investigated sibling of TGF-β1, is deregulated in rodent and human liver diseases. Former data from…”
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Hyperthermia enhances the effects of chemotherapeutic agents on pancreatic cancer cell proliferation and survival by John-Paul Bogers, Johannes, Monteiro Carvalho Mori Da Cunha, Marina Gabriela, van Zwol, Eke, Wylleman, Britta, Brancato, Luigi, Van den Bossche, Johan, Rudenko, Oleg, Janicot, Michel

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Phase I/Ib study with INT-1B3, a novel LNP-formulated micro-RNA (miR-193a-3p mimic) therapeutic for patients with advanced solid cancer by Kotecki, Nuria, Opdam, Frans, Robbrecht, Debbie, Strijbos, Michiel, Kroon, Karlijn, Janicot, Michel, Yahyanejad, Sanaz, Telford, Bryony, van den Bosch, Marion, Alemdehy, Farshid, de Gunst, Thijs, den Boer, Harm, Vos, Rogier M., van Pinxteren, Laurens, Schaapveld, Roel

“…Abstract only TPS2666 Background: MicroRNAs (miR) are naturally-occurring small non-coding RNA molecules involved in the regulation of gene expression and…”
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Targeting the WT1mut-Mir-193a Transcriptional Axis with INT-1B3, a Novel Lipid Nanoparticle-Formulated Mir-193a-3p Mimic in Acute Myeloid Leukemia by Yang, Xining, Krowiorz, Kathrin, Bhayadia, Raj, Kohlschmidt, Jessica, Nicolet, Deedra, Maetzig, Tobias, Pabst, Caroline, Hui, Jeremy, Shad, Arshia, Gao, Sharon, Stephenson, Maria, Wu, Si Wei, Bosch, Marion van den, Buelow, Daelynn, Baker, Sharyn, Escano, Leo, Lock, Frances E, Panahi, Afsaneh, MacPhee, Liam, Maksakova, Irina, Amoah, Amanda, Döhner, Konstanze, Fogelstrand, Linda, Eisfeld, Ann-Kathrin, Yahyanejad, Sanaz, Janicot, Michel, Oakes, Christopher C., Klusmann, Jan-Henning, Rouhi, Arefeh, Kuchenbauer, Florian

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