Search Results - "Jani, Nital"

Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma by Gonzalez-Meljem, Jose Mario, Haston, Scott, Carreno, Gabriela, Apps, John R., Pozzi, Sara, Stache, Christina, Kaushal, Grace, Virasami, Alex, Panousopoulos, Leonidas, Mousavy-Gharavy, Seyedeh Neda, Guerrero, Ana, Rashid, Mamunur, Jani, Nital, Goding, Colin R., Jacques, Thomas S., Adams, David J., Gil, Jesus, Andoniadou, Cynthia L., Martinez-Barbera, Juan Pedro

“…Senescent cells may promote tumour progression through the activation of a senescence-associated secretory phenotype (SASP), whether these cells are capable of…”
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Molecular profiling and preclinical targeted therapeutic testing in adamantinomatous craniopharyngioma by Apps, John, Dr, Carreno, Gabriela, BSc, Boult, Jessica, PhD, Gutteridge, Alice, MSc, Danielson, Laura, PhD, Jani, Nital, MSc, Tossell, Kyoko, PhD, Forshew, Tim, PhD, Hargrave, Darren, MD, Chesler, Louis, PhD, Robinson, Simon, PhD, Jacques, Thomas, PhD, Williams, Hywel, PhD, Martinez-Barbera, Juan Pedro, PhD

“…Abstract Background Adamantinomatous craniopharyngiomas (ACP) are histologically benign but clinically aggressive tumours that lead to hypothalamic injury,…”
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Tumour compartment transcriptomics demonstrates the activation of inflammatory and odontogenic programmes in human adamantinomatous craniopharyngioma and identifies the MAPK/ERK pathway as a novel therapeutic target by Apps, John R., Carreno, Gabriela, Gonzalez-Meljem, Jose Mario, Haston, Scott, Guiho, Romain, Cooper, Julie E., Manshaei, Saba, Jani, Nital, Hölsken, Annett, Pettorini, Benedetta, Beynon, Robert J., Simpson, Deborah M., Fraser, Helen C., Hong, Ying, Hallang, Shirleen, Stone, Thomas J., Virasami, Alex, Donson, Andrew M., Jones, David, Aquilina, Kristian, Spoudeas, Helen, Joshi, Abhijit R., Grundy, Richard, Storer, Lisa C. D., Korbonits, Márta, Hilton, David A., Tossell, Kyoko, Thavaraj, Selvam, Ungless, Mark A., Gil, Jesus, Buslei, Rolf, Hankinson, Todd, Hargrave, Darren, Goding, Colin, Andoniadou, Cynthia L., Brogan, Paul, Jacques, Thomas S., Williams, Hywel J., Martinez-Barbera, Juan Pedro

“…Adamantinomatous craniopharyngiomas (ACPs) are clinically challenging tumours, the majority of which have activating mutations in CTNNB1 . They are…”
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CR-16EXPRESSION ANALYSIS OF ADAMANTINOMATOUS CRANIOPHARYNGIOMA REVEALS NETWORKS OF CO-EXPRESSED GENE NETWORKS ASSOCIATED WITH DIFFERENT CELLULAR COMPARTMENTS by Apps, John, Williams, Hywel, Jani, Nital, Stone, Thomas, Virasami, Alex, Jacques, Thomas, Martinez-Barbera, Juan-Pedro

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Abstract 1804: Expression analysis of adamantinomatous craniopharyngioma suggests two subtypes associated with CTNNB1 mutational frequency and highlights potential therapeutic targets by Apps, John R., Jani, Nital, Carreno, Gabriela, Gonzalez-Meljem, Jose M., Tossell, Kyoko, Stone, Thomas J., Ungless, Mark A., Williams, Hywel J., Jacques, Thomas S., Martinez-Barbera, Juan-Pedro

“…Abstract We conducted RNA-sequencing analysis of Adamantinomatous Craniopharnygioma (ACP), including Laser capture micro-dissection (LCM) of individual…”
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