Search Results - "Jani, K"
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Microwave absorbing properties of a thermally reduced graphene oxide/nitrile butadiene rubber composite
Published in Carbon (New York) (01-05-2012)“…Reduced graphene oxide (RGO) with a layered and porous structure was synthesized by thermal exfoliation of graphite oxide. Synthesized RGO is very light weight…”
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A rheostat sets B-cell receptor repertoire selection to distinguish self from non-self
Published in Current opinion in immunology (01-12-2020)“…•BcRs bind self or non-self antigens with spectra of high to low to no avidities.•A BcR-antigen-IgM-FcμR-rheostat sets PI3K-PTEN balanced B cell…”
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Studies on thermal, morphological, electrical conductivity and LPG sensing behavior polyaniline/In2O3 nano composites thin films
Published in Ferroelectrics (10-09-2023)“…Poyaniline/In 2 O 3 were synthesized by using the in situ polymerization method for different concentrations of nano In 2 O 3 powder. The formation of…”
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Data-driven comorbidity analysis of 100 common disorders reveals patient subgroups with differing mortality risks and laboratory correlates
Published in Scientific reports (02-11-2022)“…The populational heterogeneity of a disease, in part due to comorbidity, poses several complexities. Individual comorbidity profiles, on the other hand,…”
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Functional Roles of the IgM Fc Receptor in the Immune System
Published in Frontiers in immunology (03-05-2019)“…It is now evident from studies of mice unable to secrete IgM that both non-immune "natural" and antigen-induced "immune" IgM are important for protection…”
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Whole-genome sequencing identifies variants in ANK1, LRRN1, HAS1, and other genes and regulatory regions for stroke in type 1 diabetes
Published in Scientific reports (11-06-2024)“…Individuals with type 1 diabetes (T1D) carry a markedly increased risk of stroke, with distinct clinical and neuroimaging characteristics as compared to those…”
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Differential metabolomic signatures of declining renal function in Types 1 and 2 diabetes
Published in Nephrology, dialysis, transplantation (01-10-2021)“…Abstract Background Chronic kidney disease (CKD) shows different clinical features in Types1 (T1D) and 2 diabetes (T2D). Metabolomics have recently provided…”
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Physiological and Pathophysiological Roles of IgM Fc Receptor (FcµR) Isoforms
Published in International journal of molecular sciences (01-03-2023)“…IgM is the first antibody to emerge during phylogeny, ontogeny, and immune responses and serves as a first line of defense. Effector proteins interacting with…”
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The miR-221/222 cluster regulates hematopoietic stem cell quiescence and multipotency by suppressing both Fos/AP-1/IEG pathway activation and stress-like differentiation to granulocytes
Published in PLoS biology (20-11-2023)“…Throughout life, hematopoietic stem cells (HSCs), residing in bone marrow (BM), continuously regenerate erythroid/megakaryocytic, myeloid, and lymphoid cell…”
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MASP-1 induces a unique cytokine pattern in endothelial cells: a novel link between complement system and neutrophil granulocytes
Published in PloS one (29-01-2014)“…Microbial infection urges prompt intervention by the immune system. The complement cascade and neutrophil granulocytes are the predominant contributors to this…”
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Metabolomic Profile Predicts Development of Microalbuminuria in Individuals with Type 1 Diabetes
Published in Scientific reports (14-09-2018)“…Elevated urinary albumin excretion (microalbuminuria) is an early marker of diabetic nephropathy, but there is an unmet need for better biomarkers that capture…”
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Whole-exome and whole-genome sequencing of 1064 individuals with type 1 diabetes reveals novel genes for diabetic kidney disease
Published in Diabetologia (01-11-2024)“…Aims/hypothesis Diabetic kidney disease (DKD) is a severe diabetic complication that affects one third of individuals with type 1 diabetes. Although several…”
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Confirmation of GLRA3 as a susceptibility locus for albuminuria in Finnish patients with type 1 diabetes
Published in Scientific reports (17-08-2018)“…Urinary albumin excretion is an early sign of diabetic kidney disease, affecting every third individual with diabetes. Despite substantial estimated…”
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Challenges in monoclonal antibody-based therapies
Published in Annals of medicine (Helsinki) (2009)“…Therapeutic monoclonal antibodies (mAbs) are the fastest growing class of new therapeutic molecules. They hold great promises for the treatment of a variety of…”
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Endothelial cell activation during edematous attacks of hereditary angioedema types I and II
Published in Journal of allergy and clinical immunology (01-06-2014)“…Background Hereditary angioedema (HAE) caused by C1-inhibitor (C1-INH) deficiency (HAE–C1-INH) is a potentially life-threatening rare disease caused by the…”
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Enhanced Mott cell formation linked with IgM Fc receptor (FcμR) deficiency
Published in European journal of immunology (01-07-2023)“…In previous studies, Mott cells, an unusual form of plasma cells containing Ig‐inclusion bodies, were frequently observed in peripheral lymphoid tissues in our…”
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Functions of IgM fc receptor (FcµR) related to autoimmunity
Published in Autoimmunity (Chur, Switzerland) (01-12-2024)“…Unlike Fc receptors for switched immunoglobulin (Ig) isotypes, Fc receptor for IgM (FcµR) is selectively expressed by lymphocytes. The ablation of the FcµR…”
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FcRn Overexpression Expands Diversity of the Humoral Immune Response in bFcRn Transgenic Mice
Published in Frontiers in immunology (21-08-2020)“…The neonatal Fc receptor (FcRn) plays key roles in IgG and albumin homeostasis, maternal IgG transport, and antigen presentation of IgG-opsonized antigens…”
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A Rapid Switch Bridge Selection Method for Fully Integrated DCDC Buck Converters
Published in IEEE transactions on power electronics (01-08-2015)“…This letter presents a method for optimum selection of synchronous buck converter switch bridge topology and devices in the CMOS technology of choice. The…”
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