Search Results - "Jangra, Rohit K."

Regulation of Hepatitis C Virus Translation and Infectious Virus Production by the MicroRNA miR-122 by Jangra, Rohit K, Yi, Minkyung, Lemon, Stanley M

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A naturally occurring antiviral ribonucleotide encoded by the human genome by Gizzi, Anthony S., Grove, Tyler L., Arnold, Jamie J., Jose, Joyce, Jangra, Rohit K., Garforth, Scott J., Du, Quan, Cahill, Sean M., Dulyaninova, Natalya G., Love, James D., Chandran, Kartik, Bresnick, Anne R., Cameron, Craig E., Almo, Steven C.

“…Viral infections continue to represent major challenges to public health, and an enhanced mechanistic understanding of the processes that contribute to viral…”
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A Replication-Competent Vesicular Stomatitis Virus for Studies of SARS-CoV-2 Spike-Mediated Cell Entry and Its Inhibition by Dieterle, M. Eugenia, Haslwanter, Denise, Bortz, Robert H., Wirchnianski, Ariel S., Lasso, Gorka, Vergnolle, Olivia, Abbasi, Shawn A., Fels, J. Maximilian, Laudermilch, Ethan, Florez, Catalina, Mengotto, Amanda, Kimmel, Duncan, Malonis, Ryan J., Georgiev, George, Quiroz, Jose, Barnhill, Jason, Pirofski, Liise-anne, Daily, Johanna P., Dye, John M., Lai, Jonathan R., Herbert, Andrew S., Chandran, Kartik, Jangra, Rohit K.

“…There is an urgent need for vaccines and therapeutics to prevent and treat COVID-19. Rapid SARS-CoV-2 countermeasure development is contingent on the…”
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Stabilization of hepatitis C virus RNA by an Ago2—miR-122 complex by Shimakami, Tetsuro, Yamane, Daisuke, Jangra, Rohit K., Kempf, Brian J., Spaniel, Carolyn, Barton, David J., Lemon, Stanley M.

“…MicroRNAs (miRNAs) are small noncoding RNAs that regulate eukaryotic gene expression by binding to regions of imperfect complementarity in mRNAs, typically in…”
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Editorial: Antiviral monoclonal antibody therapies by Florez, Catalina, Haslwanter, Denise, Jangra, Rohit K

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Longitudinal dynamics of the human B cell response to the yellow fever 17D vaccine by Wec, Anna Z., Haslwanter, Denise, Abdiche, Yasmina N., Shehata, Laila, Pedreño-Lopez, Nuria, Moyer, Crystal L., Bornholdt, Zachary A., Lilov, Asparouh, Nett, Juergen H., Jangra, Rohit K., Brown, Michael, Watkins, David I., Ahlm, Clas, Forsell, Mattias N., Rey, Félix A., Barba-Spaeth, Giovanna, Chandran, Kartik, Walker, Laura M.

“…A comprehensive understanding of the development and evolution of human B cell responses induced by pathogen exposure will facilitate the design of…”
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Antibodies from a Human Survivor Define Sites of Vulnerability for Broad Protection against Ebolaviruses by Wec, Anna Z., Herbert, Andrew S., Murin, Charles D., Nyakatura, Elisabeth K., Abelson, Dafna M., Fels, J. Maximilian, He, Shihua, James, Rebekah M., de La Vega, Marc-Antoine, Zhu, Wenjun, Bakken, Russell R., Goodwin, Eileen, Turner, Hannah L., Jangra, Rohit K., Zeitlin, Larry, Qiu, Xiangguo, Lai, Jonathan R., Walker, Laura M., Ward, Andrew B., Dye, John M., Chandran, Kartik, Bornholdt, Zachary A.

“…Experimental monoclonal antibody (mAb) therapies have shown promise for treatment of lethal Ebola virus (EBOV) infections, but their species-specific…”
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The discovery of Bombali virus adds further support for bats as hosts of ebolaviruses by Goldstein, Tracey, Anthony, Simon J., Gbakima, Aiah, Bird, Brian H., Bangura, James, Tremeau-Bravard, Alexandre, Belaganahalli, Manjunatha N., Wells, Heather L., Dhanota, Jasjeet K., Liang, Eliza, Grodus, Michael, Jangra, Rohit K., DeJesus, Veronica A., Lasso, Gorka, Smith, Brett R., Jambai, Amara, Kamara, Brima O., Kamara, Sorie, Bangura, William, Monagin, Corina, Shapira, Sagi, Johnson, Christine K., Saylors, Karen, Rubin, Edward M., Chandran, Kartik, Lipkin, W. Ian, Mazet, Jonna A. K.

“…Here we describe the complete genome of a new ebolavirus, Bombali virus (BOMV) detected in free-tailed bats in Sierra Leone (little free-tailed ( Chaerephon…”
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A "Trojan horse" bispecific-antibody strategy for broad protection against ebolaviruses by Wec, Anna Z., Nyakatura, Elisabeth K., Herbert, Andrew S., Howell, Katie A., Holtsberg, Frederick W., Bakken, Russell R., Mittler, Eva, Christin, John R., Shulenin, Sergey, Jangra, Rohit K., Bharrhan, Sushma, Kuehne, Ana I., Bornholdt, Zachary A., Flyak, Andrew I., Saphire, Erica Ollmann, Crowe, James E., Aman, M. Javad, Dye, John M., Lai, Jonathan R., Chandran, Kartik

“…There is an urgent need for monoclonal antibody (mAb) therapies that broadly protect against Ebola virus and other filoviruses. The conserved, essential…”
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Functional convalescent plasma antibodies and pre-infusion titers shape the early severe COVID-19 immune response by Herman, Jonathan D., Wang, Chuangqi, Loos, Carolin, Yoon, Hyunah, Rivera, Johanna, Eugenia Dieterle, M., Haslwanter, Denise, Jangra, Rohit K., Bortz, Robert H., Bar, Katharine J., Julg, Boris, Chandran, Kartik, Lauffenburger, Douglas, Pirofski, Liise-anne, Alter, Galit

“…Transfer of convalescent plasma (CP) had been proposed early during the SARS-CoV-2 pandemic as an accessible therapy, yet trial results worldwide have been…”
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A single-point mutation in the rubella virus E1 glycoprotein promotes rescue of recombinant vesicular stomatitis virus by Das, Pratyush Kumar, Gonzalez, Paulina Alatriste, Jangra, Rohit K, Yin, Peiqi, Kielian, Margaret

“…Rubella virus (RuV) is an enveloped plus-sense RNA virus and a member of the genus. RuV infection in pregnant women can lead to miscarriage or an array of…”
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DDX6 (Rck/p54) Is Required for Efficient Hepatitis C Virus Replication but Not for Internal Ribosome Entry Site-Directed Translation by Jangra, Rohit K, Yi, MinKyung, Lemon, Stanley M

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Prefusion-stabilized SARS-CoV-2 S2-only antigen provides protection against SARS-CoV-2 challenge by Hsieh, Ching-Lin, Leist, Sarah R., Miller, Emily Happy, Zhou, Ling, Powers, John M., Tse, Alexandra L., Wang, Albert, West, Ande, Zweigart, Mark R., Schisler, Jonathan C., Jangra, Rohit K., Chandran, Kartik, Baric, Ralph S., McLellan, Jason S.

“…Ever-evolving SARS-CoV-2 variants of concern (VOCs) have diminished the effectiveness of therapeutic antibodies and vaccines. Developing a coronavirus vaccine…”
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Two Point Mutations in Old World Hantavirus Glycoproteins Afford the Generation of Highly Infectious Recombinant Vesicular Stomatitis Virus Vectors by Slough, Megan M, Chandran, Kartik, Jangra, Rohit K

“…Rodent-to-human transmission of hantaviruses is associated with severe disease. Currently, no FDA-approved, specific antivirals or vaccines are available, and…”
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Base Pairing between Hepatitis C Virus RNA and MicroRNA 122 3′ of Its Seed Sequence Is Essential for Genome Stabilization and Production of Infectious Virus by SHIMAKAMI, Tetsuro, YAMANE, Daisuke, WELSCH, Christoph, HENSLEY, Lucinda, JANGRA, Rohit K, LEMON, Stanley M

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Direct Intracellular Visualization of Ebola Virus-Receptor Interaction by In Situ Proximity Ligation by Mittler, Eva, Alkutkar, Tanwee, Jangra, Rohit K, Chandran, Kartik

“…Ebola virus (EBOV) entry into host cells comprises stepwise and extensive interactions of the sole viral surface glycoprotein (GP) with multiple host factors…”
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Direct Visualization of Ebola Virus Fusion Triggering in the Endocytic Pathway by Spence, Jennifer S, Krause, Tyler B, Mittler, Eva, Jangra, Rohit K, Chandran, Kartik

“…Ebola virus (EBOV) makes extensive and intricate use of host factors in the cellular endosomal/lysosomal pathway to release its genome into the cytoplasm and…”
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Editorial: Influence of Protein-Protein Interactions (PPIs) on the Outcome of Viral Infections by Jangra, Rohit K., Llabrés, Mercè, Guardado-Calvo, Pablo, Mittler, Eva, Lasso, Gorka

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Reovirus infection is regulated by NPC1 and endosomal cholesterol homeostasis by Ortega-Gonzalez, Paula, Taylor, Gwen, Jangra, Rohit K, Tenorio, Raquel, Fernandez de Castro, Isabel, Mainou, Bernardo A, Orchard, Robert C, Wilen, Craig B, Brigleb, Pamela H, Sojati, Jorna, Chandran, Kartik, Sachse, Martin, Risco, Cristina, Dermody, Terence S

“…Cholesterol homeostasis is required for the replication of many viruses, including Ebola virus, hepatitis C virus, and human immunodeficiency virus-1…”
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Haploid Genetic Screen Reveals a Profound and Direct Dependence on Cholesterol for Hantavirus Membrane Fusion by Kleinfelter, Lara M, Jangra, Rohit K, Jae, Lucas T, Herbert, Andrew S, Mittler, Eva, Stiles, Katie M, Wirchnianski, Ariel S, Kielian, Margaret, Brummelkamp, Thijn R, Dye, John M, Chandran, Kartik

“…Hantaviruses cause hemorrhagic fever with renal syndrome (HFRS) in the Old World and a highly fatal hantavirus cardiopulmonary syndrome (HCPS) in the New…”
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