Search Results - "Jang, Seil"
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Synaptic abnormalities and cytoplasmic glutamate receptor aggregates in contactin associated protein-like 2/Caspr2 knockout neurons
Published in Proceedings of the National Academy of Sciences - PNAS (12-05-2015)“…Central glutamatergic synapses and the molecular pathways that control them are emerging as common substrates in the pathogenesis of mental disorders. Genetic…”
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2
Clmp Regulates AMPA and Kainate Receptor Responses in the Neonatal Hippocampal CA3 and Kainate Seizure Susceptibility in Mice
Published in Frontiers in synaptic neuroscience (21-12-2020)“…Synaptic adhesion molecules regulate synapse development through trans-synaptic adhesion and assembly of diverse synaptic proteins. Many synaptic adhesion…”
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3
Synaptic adhesion molecule IgSF11 regulates synaptic transmission and plasticity
Published in Nature neuroscience (01-01-2016)“…Synaptic adhesion molecules are known to regulate synapse development, but growing evidence indicates that they also regulate synaptic function and plasticity…”
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4
Synaptic adhesion molecules and excitatory synaptic transmission
Published in Current opinion in neurobiology (01-08-2017)“…Highlights • Synaptic scaffolding proteins may bring together adhesion molecules and receptors. • Adhesion molecules and receptors also directly interact on…”
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5
EMC chaperone–CaV structure reveals an ion channel assembly intermediate
Published in Nature (London) (13-07-2023)“…Voltage-gated ion channels (VGICs) comprise multiple structural units, the assembly of which is required for function 1 , 2 . Structural understanding of how…”
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6
Development of an antibody-like T-cell engager based on VH-VL heterodimer formation and its application in cancer therapy
Published in Biomaterials (01-04-2021)“…Following the clinical success of immunotherapeutic antibodies, bispecific antibodies for cytotoxic effector cell redirection, tumor-targeted immunomodulation…”
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7
Development of covalent chemogenetic K 2P channel activators
Published in Cell chemical biology (18-07-2024)“…K potassium channels regulate excitability by affecting cellular resting membrane potential in the brain, cardiovascular system, immune cells, and sensory…”
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Haploinsufficiency of Cyfip2 Causes Lithium‐Responsive Prefrontal Dysfunction
Published in Annals of neurology (01-09-2020)“…Objective Genetic variants of the cytoplasmic FMR1‐interacting protein 2 (CYFIP2) encoding an actin‐regulatory protein are associated with brain disorders,…”
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Abstract 2460: Receptor antibody conjugated engager (RACE): A novel bispecific 4-1BB engager platform for enhanced immuno-oncology therapy
Published in Cancer research (Chicago, Ill.) (22-03-2024)“…Abstract Background: Traditional immuno-oncology strategies, such as checkpoint blockade therapy, are evolving to immune cell engagers as a smarter strategy…”
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10
Cytokine engineered NK-92 therapy to improve persistence and anti-tumor activity
Published in Theranostics (01-01-2023)“…Natural killer (NK) cells are an attractive cell source in cancer immunotherapy due to their potent antitumor ability and promising safety for allogenic…”
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11
EMC chaperone-Ca V structure reveals an ion channel assembly intermediate
Published in Nature (London) (01-07-2023)“…Voltage-gated ion channels (VGICs) comprise multiple structural units, the assembly of which is required for function . Structural understanding of how VGIC…”
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12
Regulation of hippocampal long-term potentiation and long-term depression by diacylglycerol kinaseζ
Published in Hippocampus (01-05-2012)“…Diacylglycerol (DAG) is an important signaling molecule at neuronal synapses. Generation of synaptic DAG is triggered by the activation of diverse surface…”
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13
Synaptic abnormalities and cytoplasmic glutamate receptor aggregates in contactin associated protein-like 2/Caspr2knockout neurons
Published in Proceedings of the National Academy of Sciences - PNAS (12-05-2015)“…Central glutamatergic synapses and the molecular pathways that control them are emerging as common substrates in the pathogenesis of mental disorders. Genetic…”
Get full text
Journal Article -
14
DGKι regulates presynaptic release during mGluR-dependent LTD
Published in The EMBO journal (05-01-2011)“…Diacylglycerol (DAG) is an important lipid second messenger. DAG signalling is terminated by conversion of DAG to phosphatidic acid (PA) by diacylglycerol…”
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15
DGKι regulates presynaptic release during mGluR-dependent LTD: Presynaptic regulation by DGKι
Published in The EMBO journal (05-01-2011)Get full text
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16
DGK[iota] regulates presynaptic release during mGluR-dependent LTD
Published in The EMBO journal (05-01-2011)“…Diacylglycerol (DAG) is an important lipid second messenger. DAG signalling is terminated by conversion of DAG to phosphatidic acid (PA) by diacylglycerol…”
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